DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and CG32055

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_729599.1 Gene:CG32055 / 39188 FlyBaseID:FBgn0052055 Length:534 Species:Drosophila melanogaster


Alignment Length:669 Identity:132/669 - (19%)
Similarity:217/669 - (32%) Gaps:252/669 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 WNIFKICNE-------TDYELVIISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLIT 196
            |...|:.||       .|.||..:|.|   .::|:..|..|. |...|:::...         :.
  Fly    50 WKSVKVVNEHTGIERAEDGELPGLSTL---LQLDLSESGGVT-LGEKGLQDFKA---------LQ 101

  Fly   197 EMDVHHA-----------NGPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTT 250
            ::::.||           |..:|:.|...|:..:  .||...:....|      :.|.|..|...
  Fly   102 KLNLTHAQLDELKSEQFPNPSEMINFDVSYNDIL--AITTKLMSGFGN------LVYANFSENLI 158

  Fly   251 LTMEKNIF-HGKNKMSALIFNGLKIKGLTNNTFENLT-----SLNTLIFDNVFLKDLSFLRSSTL 309
            ..:|.|.| |.||         |:...||.|..||:|     :|..|...|..|:|..:.....|
  Fly   159 AVIEPNAFRHMKN---------LRFLDLTTNYQENITLGENANLRFLSISNNNLRDFQWCHLRVL 214

  Fly   310 QSSLTYCIMKVDNM---------VDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTL 365
            .        |::.:         :|:..|....||.::.||....|:........|         
  Fly   215 P--------KLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLFEIKRTLFMAP--------- 262

  Fly   366 GINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGY 430
              .|:| ||:                                   .|.:.||::..|.|:.....
  Fly   263 --GEIA-PLE-----------------------------------LLDYSSNIVKVLDDSVFCRL 289

  Fly   431 HNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDE 495
            ..|::|::..||                      |..:.|:....|.|:...:..|||.||..|:
  Fly   290 KKLRTLNLWLNQ----------------------INRIHPRAFLGLSSLQTLHLQGNKISILPDD 332

  Fly   496 YHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSD 560
            ..        |.|         |.:|.::||.          .||.:|.|..             
  Fly   333 VF--------ANL---------TALEKLDLSK----------NNIQKLGLRV------------- 357

  Fly   561 KYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLP 625
                                 |.|.||..|                 .:|....|...|::|...
  Fly   358 ---------------------FGERILRKL-----------------IYLDLSNNYIADLHPLAL 384

  Fly   626 NSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLP--ENITYLDVRNN 688
            :|:|:...|.|.||   :|.:.:..:.|....:..|.:::|.|.|:...:|.  :.:.:|::.||
  Fly   385 SSMPFIKELRLRRN---RLVSLDLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNN 446

  Fly   689 LLKYLDDGVIAFLEYRENITK---IELSGNPWECNC--------------KAKAFLSFLRRHEPM 736
            .|.:|.|     |:..:|:.:   |.|.||||:|.|              .|:...::....:|:
  Fly   447 RLTFLPD-----LKSSQNLLQLRNITLEGNPWQCLCLDEITSWLNGRHVSYARPSSAYFSGRKPL 506

  Fly   737 EYETVLRRVEITDDKCPED 755
            ...|.:       |||..|
  Fly   507 CVVTPM-------DKCLRD 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 7/27 (26%)
leucine-rich repeat 288..308 CDD:275380 5/19 (26%)
leucine-rich repeat 309..334 CDD:275380 4/33 (12%)
leucine-rich repeat 335..386 CDD:275380 9/50 (18%)
leucine-rich repeat 388..408 CDD:275380 0/19 (0%)
LRR_8 412..465 CDD:290566 9/52 (17%)
leucine-rich repeat 412..432 CDD:275378 5/19 (26%)
LRR_4 432..470 CDD:289563 5/37 (14%)
leucine-rich repeat 433..454 CDD:275378 4/20 (20%)
leucine-rich repeat 455..478 CDD:275378 3/22 (14%)
leucine-rich repeat 479..490 CDD:275378 3/10 (30%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 5/22 (23%)
leucine-rich repeat 680..706 CDD:275378 7/25 (28%)
leucine-rich repeat 707..719 CDD:275378 6/14 (43%)
leucine-rich repeat 771..791 CDD:275380
leucine-rich repeat 793..815 CDD:275378
leucine-rich repeat 816..835 CDD:275378
leucine-rich repeat 836..859 CDD:275378
TIR 974..1110 CDD:214587
CG32055NP_729599.1 leucine-rich repeat 76..99 CDD:275380 6/26 (23%)
leucine-rich repeat 100..123 CDD:275380 3/22 (14%)
LRR_8 128..180 CDD:290566 16/68 (24%)
leucine-rich repeat 128..147 CDD:275380 3/20 (15%)
leucine-rich repeat 148..171 CDD:275380 7/22 (32%)
leucine-rich repeat 172..192 CDD:275380 7/19 (37%)
LRR_RI <187..400 CDD:238064 63/370 (17%)
LRR_8 192..251 CDD:290566 13/66 (20%)
leucine-rich repeat 193..216 CDD:275380 6/30 (20%)
leucine-rich repeat 217..240 CDD:275380 2/22 (9%)
leucine-rich repeat 241..267 CDD:275380 7/37 (19%)
leucine-rich repeat 268..291 CDD:275380 6/57 (11%)
LRR_8 290..350 CDD:290566 20/108 (19%)
leucine-rich repeat 292..315 CDD:275380 7/44 (16%)
leucine-rich repeat 316..339 CDD:275380 8/39 (21%)
LRR_8 340..400 CDD:290566 22/123 (18%)
leucine-rich repeat 340..365 CDD:275380 11/68 (16%)
leucine-rich repeat 366..389 CDD:275380 6/39 (15%)
leucine-rich repeat 390..413 CDD:275380 6/25 (24%)
LRR_8 391..448 CDD:290566 14/59 (24%)
leucine-rich repeat 414..437 CDD:275380 5/22 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453557
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.