DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and CG6749

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	136/645 - (21%)
Similarity:	222/645 - (34%)	Gaps:	237/645 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 PVFH--------GWNIFKICNETDYELVIISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYL 190
            |:.|        ||..|: |:|         |..::..||:    ..:....|.||.:.
  Fly    21 PILHGADLCQPIGWRNFQ-CSE---------VASLQDLVDL----GAENWHTLAIRNVQ------ 65

  Fly   191 PSVLITEMDV-------HHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEK 248
                 ||::|       |.||         |.|               ::.|....|..|.
  Fly    66 -----TELEVGSGENADHLAN---------LLD---------------LDLTGAAPINVHT---- 97

  Fly   249 TTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSL 313
                                 ||..|       ..||..||......|.::...|...|.||
  Fly    98 ---------------------NGFSI-------LPNLRQLNLSGCGLVDIRGNHFAPESALQ--- 131

  Fly   314 TYCIMKVD---NMVDLKSFEKFTNL-EIIEVSQYKGFKNFTAFICE-PYKSHC-KFTLGINEV-- 370
                 ::|   |.::|...:.|.|| ::|    |..|.:.....|: |:.... :..||.|.:
  Fly   132 -----RIDFSHNQMELLDRDFFGNLRKLI----YANFSHNALKQCDLPHMPLLNRLELGHNRLVN 187

  Fly   371 ----ACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYH 431
                .||            ||:                      .|:...|.|.:|..|:..|.|
  Fly   188 ATFGVCP------------QLQ----------------------ELILNDNQLIQLDVNAFRGLH 218

  Fly   432 NLKSLDVSYNQLTSLSVS--QLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCD 494
            .|..|.:|.|:|:|:.:.  |....|..|::..|.:..|.|         |||....|      .
  Fly   219 GLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRP---------NVFGAVQN------F 268

  Fly   495 EYHLQEFFWYKAKLLRIKTSKFQTI--MEYIELS--SKGSFVENFFV--QNIDQLYLEANED-EI 552
            ..|||:......::..:..::|:.:  ::.:::|  |..|.....||  .::.:|||:.|.. ||
  Fly   269 VLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEI 333

  Fly   553 ----------IDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTG 607
                      :|....|  |.||:.:|             ::|.                   .|
  Fly   334 KPATFAALLNLDTLDLS--YNNLEFLE-------------EQIF-------------------GG 364

  Fly   608 EFLINCRNLSLD------IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQN 666
            ..|...|.|:|:      ::|...:|:|:...|.|..||::.|   :..:.|....:.|||:..|
  Fly   365 NTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSL---DVRMFAPMRRLQKLHLGHN 426

  Fly   667 LLRELPLHLLP--ENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAK 724
            ||.|:.|.:|.  .::..:.|.||.|.:|....::|    .|:.::.:.||||:|.|..|
  Fly   427 LLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSF----PNLKRVAIEGNPWQCPCFVK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..308	CDD:275380	4/19 (21%)
		leucine-rich repeat	309..334	CDD:275380	6/27 (22%)
		leucine-rich repeat	335..386	CDD:275380	11/59 (19%)
		leucine-rich repeat	388..408	CDD:275380	0/19 (0%)
		LRR_8	412..465	CDD:290566	17/54 (31%)
		leucine-rich repeat	412..432	CDD:275378	6/19 (32%)
		LRR_4	432..470	CDD:289563	11/39 (28%)
		leucine-rich repeat	433..454	CDD:275378	7/22 (32%)
		leucine-rich repeat	455..478	CDD:275378	5/22 (23%)
		leucine-rich repeat	479..490	CDD:275378	4/10 (40%)
		leucine-rich repeat	632..657	CDD:275378	6/24 (25%)
		leucine-rich repeat	658..679	CDD:275378	9/22 (41%)
		leucine-rich repeat	680..706	CDD:275378	6/25 (24%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	44/198 (22%)
		LRR_8	104..164	CDD:290566	18/71 (25%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	8/30 (27%)
		leucine-rich repeat	154..195	CDD:275380	10/56 (18%)
		LRR_RI	194..455	CDD:238064	75/346 (22%)
		LRR_8	194..254	CDD:290566	20/93 (22%)
		leucine-rich repeat	196..219	CDD:275380	7/44 (16%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	8/31 (26%)
		LRR_8	271..330	CDD:290566	13/58 (22%)
		leucine-rich repeat	272..295	CDD:275380	3/22 (14%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		LRR_8	319..380	CDD:290566	18/94 (19%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	9/58 (16%)
		LRR_8	368..428	CDD:290566	16/62 (26%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	6/25 (24%)
		leucine-rich repeat	418..441	CDD:275380	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930