DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr12

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_991392.1	Gene:	Tlr12 / 384059	MGIID:	3045221	Length:	906	Species:	Mus musculus

Alignment Length:	1013	Identity:	215/1013 - (21%)
Similarity:	344/1013 - (33%)	Gaps:	344/1013 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 TFEKTTLTMEKNIFHGKNKMSALI------FNGLKIKGLTNNTFENLT-SLNTLIFDNVFLKDLS 302
            |.|....|:|.....|  .:|.|:      |.|||:..|:.:..:.|. :|..|    ..|:.||
Mouse    63 TLEVVPRTVEGLCLGG--TVSTLLPDAFSAFPGLKVLALSLHLTQLLPGALRGL----GQLQSLS 121

  Fly   303 FLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGI 367
            |. .|.|:.||   .:..|...||.|.::      :.:|.          .|...|:..:...|:
Mouse   122 FF-DSPLRRSL---FLPPDAFSDLISLQR------LHISG----------PCLDKKAGIRLPPGL 166

  Fly   368 NEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDN------- 425
            ..:...|.|    .:|..:|        ....|.|   .:|||:.|..:....:|..|
Mouse   167 QWLGVTLSC----IQDVGEL--------AGMFPDL---VQGSSSRVSWTLQKLDLSSNWKLKMAS 216

  Fly   426 --SLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITT--LSPQVVEYLYSVNVFNQYG 486
              ||:|. .::.||::...|.::.:..|  .|..||:.:.:..|  |:.:.|.:
Mouse   217 PGSLQGL-QVEILDLTRTPLDAVWLKGL--GLQKLDVLYAQTATAELAAEAVAH----------- 267

  Fly   487 NKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTI----------MEYIELSSKG--SFVENFF--V 537
                     :.||.        |.:|.||..:|          ::.:.|||.|  .....|.  :
Mouse   268 ---------FELQG--------LIVKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAM 315

  Fly   538 QNIDQLYLEANE--------DEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPC 594
            ..:.:|.|..|:        :|..|..|          :..|:     .||....|:     .|.
Mouse   316 PRLQRLELSGNQLQSAVLCMNETGDVSG----------LTTLD-----LSGNRLRIL-----PPA 360

  Fly   595 PYRCSCCFEWHTGEFLINCRN-LSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASI 658
            .:.|..    |..|.|:.... |||:.|  |...:....||.||.|.:
Mouse   361 AFSCLP----HLRELLLRYNQLLSLEGY--LFQELQQLETLKLDGNPL----------------- 402

  Fly   659 HKLHMSQNLLRELP-----------LHLLPE-------NITYLDVRNNLLKYLDDGVIAFLEYRE 705
              ||:.:|.|..||           :.:.||       |:..|.::   |..|....:.||..
Mouse   403 --LHLGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLK---LPALPAPAVLFLPM-- 460

  Fly   706 NITKIEL---SGNPWECNCKAKAFLSFLRRHEPMEYETV--------------------LRRVEI 747
            .:|.:||   ||...........|.|       :|..|:                    |:::.:
Mouse   461 YLTSLELHIASGTTEHWTLSPAIFPS-------LETLTISGGGLKLKLGSQNASGVFPALQKLSL 518

  Fly   748 TDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSS---- 808
            ..:..  |..|...|||            ..|.::|:|              .||:.|.:.
Mouse   519 LKNSL--DAFCSQGTSN------------LFLWQLPKL--------------QSLRVWGAGNSSR 555

  Fly   809 --LLPGYSSVTRFYLAHNRLSDIDQ------------LPDKLEYLDISNNNFSALDDRVRGFLQK 859
              |:.|..|:....||  .|..|.|            || :|:.|.:|:....:|.  ...|  :
Mouse   556 PCLITGLPSLRELKLA--SLQSITQPRSVQLEELVGDLP-QLQALVLSSTGLKSLS--AAAF--Q 613

  Fly   860 RMNSSQ-----------LQLSL-------------FGNPWTCRCEDKDFLVFVKEQAKNIANASA 900
            |::|.|           ||.||             ..:...|.|.:.....:||...|     :.
Mouse   614 RLHSLQVLVLEYEKDLMLQDSLREYSPQMPHYIYILESNLACHCANAWMEPWVKRSTK-----TY 673

  Fly   901 IQCIDT----GRSLIEVEET------DICPSVL---IYYTSLAVSLLIIALSI-----NVFICFR 947
            |...|.    |:..:....:      |.||..|   ::..|.|:..::|||.:     |.:|.:.
Mouse   674 IYIRDNRLCPGQDRLSARGSLPSFLWDHCPQTLELKLFLASSALVFMLIALPLLQEARNSWIPYL 738

  Fly   948 QPIM-IWFYEHEICLSLAARRELDEDKK--YDAFLSFTHKDED-LIEEFVDRLEN------GRHK 1002
            |.:. :|..        ..|.:.|:.|:  :|.|:|...:|:. :|||.:..||.      |
Mouse   739 QALFRVWLQ--------GLRGKGDKGKRFLFDVFVSHCRQDQGWVIEELLPALEGFLPAGLG--- 792

  Fly  1003 FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLA----LHATSRDRCK 1063
            .|||...||:..|:.:.|.:..|:..||..:.:::...|.:...|||.|||    |.|.|..  .
Mouse   793 LRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRLATSLLLAAPSPP--V 855

  Fly  1064 RLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRNNPNFW 1101
            .|:|.|.|...|      :|..|..|...|.|.:...|
Mouse   856 LLLVFLEPISRH------QLPGYHRLARLLRRGDYCLW 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/29 (28%)
		leucine-rich repeat	288..308	CDD:275380	6/19 (32%)
		leucine-rich repeat	309..334	CDD:275380	7/24 (29%)
		leucine-rich repeat	335..386	CDD:275380	7/50 (14%)
		leucine-rich repeat	388..408	CDD:275380	2/19 (11%)
		LRR_8	412..465	CDD:290566	13/61 (21%)
		leucine-rich repeat	412..432	CDD:275378	6/28 (21%)
		LRR_4	432..470	CDD:289563	9/39 (23%)
		leucine-rich repeat	433..454	CDD:275378	4/20 (20%)
		leucine-rich repeat	455..478	CDD:275378	6/24 (25%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	5/24 (21%)
		leucine-rich repeat	658..679	CDD:275378	8/38 (21%)
		leucine-rich repeat	680..706	CDD:275378	5/25 (20%)
		leucine-rich repeat	707..719	CDD:275378	5/14 (36%)
		leucine-rich repeat	771..791	CDD:275380	3/19 (16%)
		leucine-rich repeat	793..815	CDD:275378	5/27 (19%)
		leucine-rich repeat	816..835	CDD:275378	7/30 (23%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587	41/141 (29%)
Tlr12	NP_991392.1	LRR 1	91..114		7/22 (32%)
		leucine-rich repeat	94..116	CDD:275380	6/25 (24%)
		LRR 2	115..140		9/28 (32%)
		leucine-rich repeat	117..143	CDD:275380	11/29 (38%)
		LRR 3	142..170		5/43 (12%)
		leucine-rich repeat	144..191	CDD:275380	10/77 (13%)
		LRR 4	198..222		4/23 (17%)
		leucine-rich repeat	201..224	CDD:275380	5/23 (22%)
		LRR 5	224..247		5/24 (21%)
		leucine-rich repeat	225..247	CDD:275380	5/23 (22%)
		leucine-rich repeat	248..293	CDD:275380	12/72 (17%)
		LRR 6	267..290		7/50 (14%)
		LRR_8	269..328	CDD:290566	15/66 (23%)
		LRR 7	291..314		5/22 (23%)
		leucine-rich repeat	294..317	CDD:275380	5/22 (23%)
		LRR 8	316..338		3/21 (14%)
		leucine-rich repeat	318..343	CDD:275380	5/24 (21%)
		LRR 9	341..364		6/42 (14%)
		LRR_8	342..402	CDD:290566	20/85 (24%)
		leucine-rich repeat	344..367	CDD:275380	6/36 (17%)
		LRR_RI	364..625	CDD:238064	67/332 (20%)
		LRR 10	366..388		8/27 (30%)
		leucine-rich repeat	368..391	CDD:275380	7/24 (29%)
		LRR 11	389..412		9/41 (22%)
		leucine-rich repeat	392..415	CDD:275380	10/41 (24%)
		LRR 12	414..436		3/21 (14%)
		leucine-rich repeat	416..436	CDD:275380	2/19 (11%)
		leucine-rich repeat	440..512	CDD:275380	14/83 (17%)
		LRR 13	462..484		5/21 (24%)
		LRR 14	485..508		3/29 (10%)
		LRR 15	510..533		4/24 (17%)
		leucine-rich repeat	513..564	CDD:275380	14/78 (18%)
		LRR 16	562..586		6/25 (24%)
		leucine-rich repeat	565..593	CDD:275380	7/30 (23%)
		LRR 17	591..614		7/27 (26%)
		leucine-rich repeat	594..617	CDD:275380	6/26 (23%)
		TIR	761..902	CDD:214587	41/138 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920