DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Toll-7

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	1259	Identity:	260/1259 - (20%)
Similarity:	461/1259 - (36%)	Gaps:	408/1259 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NNKDDPPNSHQKSKSNNDARNLNSRVRVRARVRVVPGEMRMGDINCSNGLGNIREDYCEIYLDEL 100
            ||....|:.......|....||     .|.|:|... :|...|:||..|.|:
  Fly   199 NNLRQLPSGFLCPVGNLQVLNL-----TRNRIRTAE-QMGFADMNCGAGSGS------------- 244

  Fly   101 GENGTCSIANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVIISVLGIRSEVD 165
                    |.:|         |..|....|....:...|.|.::
  Fly   245 --------AGSE---------LQVLDASHNELRSISESWGISRL--------------------- 271

  Fly   166 MRISPAVQYLSLL--GIREISGYDIY-LPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNY 227
                ..:|:|:|.  .:.|:||..:. |.|:.|                       ||  ::||:
  Fly   272 ----RRLQHLNLAYNNLSELSGEALAGLASLRI-----------------------VN--LSNNH 307

  Fly   228 IRKTM--------NNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFEN 284
            : :|:        ....:|.:..:..:|     :.|.:||   ::..|:...|....||:|..:|
  Fly   308 L-ETLPEGLFAGSKELREIHLQQNELYE-----LPKGLFH---RLEQLLVVDLSGNQLTSNHVDN 363

  Fly   285 LT--SLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYK-GF 346
            .|  .|..||..|:            ..::||        .:|.::|::...|:|:.:.... |.
  Fly   364 TTFAGLIRLIVLNL------------AHNALT--------RIDYRTFKELYFLQILNLRNNSIGH 408

  Fly   347 KNFTAFICEP-YKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSS 410
            ....||:  | |..|   ||.:.|       |..:..|      |.....|..:          |
  Fly   409 IEDNAFL--PLYNLH---TLNLAE-------NRLHTLD------DKLFNGLYVL----------S 445

  Fly   411 ALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPES------LHYLDIRHNKITTLS 469
            .|...:||::.:.....:...:||.||:|.|||     :::|.:      |..||:..|:|.|..
  Fly   446 KLTLNNNLISVVEPAVFKNCSDLKELDLSSNQL-----NEVPRALQDLAMLRTLDLGENQIRTFD 505

  Fly   470 PQVVEYLYSVN----VFNQYGN-KWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKG 529
            .|..:.|:.:.    :.||.|| ...::.|...|        .:|.:..::.|:|       .:|
  Fly   506 NQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRL--------SVLNLAKNRIQSI-------ERG 555

  Fly   530 SFVENFFVQ--NIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNS 592
            ||.:||.::  .:|:.:|.    :|...|........|.|.|  ||.:|     ||
  Fly   556 SFDKNFELEAIRLDRNFLA----DINGVFATLVSLLWLNLSE--NHLVW-----FD--------- 600

  Fly   593 PCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHAS 657
                                        |..:|:::.:   |.:..|.|..|.|...|  .....
  Fly   601 ----------------------------YAFIPSNLKW---LDIHGNYIEALGNYYKL--QEEIR 632

  Fly   658 IHKLHMSQNLLRELPLHLLPENITYLDVRNNLL------KYLDDGVIAFLE-YRENITKIE---- 711
            :..|..|.|.:.|:....:|..|..|.:.|||:      .::|...:|.:: |...::|::
  Fly   633 VKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQL 697

  Fly   712 ---------------LSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKC--------- 752
                           |.|||:||:|.    :.:|:|...:......|.:::.:.:|
  Fly   698 RVAPVVAPKPLPEFYLGGNPFECDCT----MDWLQRINNLTTRQHPRVMDMANIECVMPHARGAA 758

  Fly   753 --------PEDCIC-----------CVD--------TSNSDSLAY--------VVDCSGKELSEI 782
                    |:|.:|           |.|        |..|:...|        ||||.|::.:|:
  Fly   759 VRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTEL 823

  Fly   783 P-QLPT------------PTYGQTTLVFERN---------SLKKWPSSLLPGYSSVTRFYLAHNR 825
            | ::|.            |.......:..:|         .:....:......:|:...:||.|:
  Fly   824 PRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNK 888

  Fly   826 LS-----DIDQLPDKLEYLDISNNNFSALDDRVRGFLQK----RMNSSQL--------------- 866
            |.     :.:|| ..|..|.:.||..:.:::.....|..    |::.::|
  Fly   889 LRTLHGYEFEQL-SALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGT 952

  Fly   867 ---QLSLFGNPWTCRCEDKDFLV-FVKEQAKNIANASAIQCI----DTGRSLIE--------VEE 915
               .:||..|.|:|||:....|. :|.:.|..:.:|..|.|:    .||.:.:|        :|:
  Fly   953 RLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEK 1017

  Fly   916 TDI--------C--------------PSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHE 958
            .::        |              |...|...:.|::||.:.:.|.:...||:.:.||.:.|.
  Fly  1018 RELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHY 1082

  Fly   959 ICLSLAARRELDEDKKYDAFLSFTHKDEDLI-EEFVDRLENGRHKFRLCFYLRDWLVGESIPDCI 1022
            .......|.| :.:|.|||.|..:.||.:.: :....:||.||...|:|...|| |..::....:
  Fly  1083 GVRVFGPRCE-ESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRD-LAHDATHYQL 1145

  Fly  1023 NQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYM 1087
            .::.:.|||::||:|:|||::.|.|.|.|.::|...|.|.::|:::..|:|....:.|.||..|:
  Fly  1146 LEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYL 1210

  Fly  1088 VLNTY--LDRNNPNFWNKLMYSMP 1109
            ..:..  :.|::.:||.||.|::|
  Fly  1211 KTSAVHRIRRSDRHFWEKLRYALP 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	7/24 (29%)
		leucine-rich repeat	288..308	CDD:275380	4/19 (21%)
		leucine-rich repeat	309..334	CDD:275380	4/24 (17%)
		leucine-rich repeat	335..386	CDD:275380	13/52 (25%)
		leucine-rich repeat	388..408	CDD:275380	2/19 (11%)
		LRR_8	412..465	CDD:290566	16/58 (28%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	15/43 (35%)
		leucine-rich repeat	433..454	CDD:275378	9/20 (45%)
		leucine-rich repeat	455..478	CDD:275378	8/22 (36%)
		leucine-rich repeat	479..490	CDD:275378	4/15 (27%)
		leucine-rich repeat	632..657	CDD:275378	6/24 (25%)
		leucine-rich repeat	658..679	CDD:275378	5/20 (25%)
		leucine-rich repeat	680..706	CDD:275378	8/32 (25%)
		leucine-rich repeat	707..719	CDD:275378	5/30 (17%)
		leucine-rich repeat	771..791	CDD:275380	9/32 (28%)
		leucine-rich repeat	793..815	CDD:275378	1/30 (3%)
		leucine-rich repeat	816..835	CDD:275378	6/23 (26%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587	45/139 (32%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	1/1 (100%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	20/95 (21%)
		leucine-rich repeat	191..214	CDD:275380	3/14 (21%)
		leucine-rich repeat	215..248	CDD:275380	12/59 (20%)
		LRR_RI	247..501	CDD:238064	72/374 (19%)
		LRR_8	247..308	CDD:290566	19/119 (16%)
		leucine-rich repeat	249..273	CDD:275380	5/48 (10%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	14/92 (15%)
		leucine-rich repeat	298..321	CDD:275380	6/48 (13%)
		leucine-rich repeat	322..345	CDD:275380	5/30 (17%)
		LRR_8	345..406	CDD:290566	17/80 (21%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		leucine-rich repeat	372..395	CDD:275380	7/42 (17%)
		leucine-rich repeat	396..419	CDD:275380	6/24 (25%)
		LRR_8	419..478	CDD:290566	18/84 (21%)
		leucine-rich repeat	420..443	CDD:275380	8/38 (21%)
		leucine-rich repeat	444..467	CDD:275380	4/32 (13%)
		LRR_RI	466..622	CDD:238064	48/226 (21%)
		leucine-rich repeat	468..488	CDD:275380	9/24 (38%)
		LRR_8	491..549	CDD:290566	15/65 (23%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	4/20 (20%)
		leucine-rich repeat	539..562	CDD:275380	8/37 (22%)
		leucine-rich repeat	563..585	CDD:275380	4/25 (16%)
		leucine-rich repeat	586..626	CDD:275380	15/86 (17%)
		leucine-rich repeat	627..653	CDD:275380	5/27 (19%)
		LRRCT	716..772	CDD:214507	11/59 (19%)
		LRRNT	796..830	CDD:214470	10/33 (30%)
		leucine-rich repeat	812..829	CDD:275380	7/16 (44%)
		leucine-rich repeat	833..854	CDD:275380	1/20 (5%)
		LRR_8	853..913	CDD:290566	12/60 (20%)
		leucine-rich repeat	855..878	CDD:275380	0/22 (0%)
		LRR_4	878..918	CDD:289563	11/40 (28%)
		leucine-rich repeat	879..902	CDD:275380	6/23 (26%)
		leucine-rich repeat	903..926	CDD:275380	5/22 (23%)
		leucine-rich repeat	927..953	CDD:275380	2/25 (8%)
		TIR	1098..1235	CDD:214587	45/138 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468847
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	6	5.750