DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and Tlr3

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_942086.2 Gene:Tlr3 / 364594 RGDID:735171 Length:905 Species:Rattus norvegicus


Alignment Length:946 Identity:202/946 - (21%)
Similarity:346/946 - (36%) Gaps:286/946 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   364 TLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELPDNSL 427
            :|.|..|:...:|...||      ..||....||.|| .||   ...:.|....|.|..||..:.
  Rat    17 SLWILVVSSTNQCTVRYN------VADCSHLKLTHIPDDLP---SNITVLNLTHNQLRGLPPANF 72

  Fly   428 EGYHNLKSLDVSYNQLTSL--SVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWS 490
            ..|..|..||..:|.::.|  .:.|:...|..|:::||:::.:|.|.  :.:..|:         
  Rat    73 TRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQT--FAFCTNL--------- 126

  Fly   491 IYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIEL--------SSK-GSFVENFFVQNIDQLYLE 546
               .|.||.     ...:.:||::.|:.....|:|        |:| |:.|:   ::|:.:|.|.
  Rat   127 ---TELHLM-----SNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKLGTGVQ---LENLQELLLA 180

  Fly   547 ANE-----DEIIDAFGPSDKYFNLKLMEALNHAIWLFS-------GEFDEIILHHLNSPCPYRCS 599
            .|:     .|.:|..|.|    :|:.::..::.:..||       |:...::|::..........
  Rat   181 KNKIFALRSEELDFLGNS----SLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTEK 241

  Fly   600 CCFEWHTGEFLINCRNLSL------------------------------------DIYPRLPN-- 626
            .|:|...    .:.:||||                                    |.:..||:  
  Rat   242 LCWELSN----TSIQNLSLANNQLLATSNSTFSGLKQTNLTSLDLSYNSLRYVGNDAFSWLPHLK 302

  Fly   627 --SIPYKTTLYLDRNEIRKLTN-----------TESLVVAGHASI-----------HKLHMSQNL 667
              |:.|.....|..:..|.|:|           .:|:.:|.|.:|           ..|:|..|.
  Rat   303 YLSLEYNNIQSLTPHSFRGLSNLRYLSLKRAFTKQSVALASHPNIDDFSFQWLKCLEHLNMDDNT 367

  Fly   668 --------------LRELPLH---------------------LLPENITYLDVRNNLLKYLDD-- 695
                          |:.|.|.                     ||..|:|    :|::.|....  
  Rat   368 IPGIKSNTFTGLVSLKYLSLSKTFTGLQTLTNETFVSLTHSPLLTLNLT----KNHISKIASGTF 428

  Fly   696 ---GVIAFLEYRENITKIELSGNPW-------ECNCKAKAFLSFLRRH---EPMEYETVLRRVEI 747
               |.:..|:...|..:.||:|..|       |.......:|....:.   .|.....:||||.:
  Rat   429 SWLGQLRILDLGLNEIEQELTGQEWRGLGNIFEIYLSYNKYLQLTSKSFTLVPSLQRLMLRRVAL 493

  Fly   748 TD-DKCPEDC-----ICCVDTSNSDSLAYVVD-CSGKELSEIPQLPTPTYGQTTLVFERNSLKK- 804
            .. |..|...     :..:|.||::......| ..|.|..||            |.|:.|:|.: 
  Rat   494 KSVDISPSPFRPLYNLTILDLSNNNIANLNEDLLEGLENLEI------------LDFQHNNLARL 546

  Fly   805 W-------PSSLLPGYSSVTRFYLAHNRLSDIDQLPDK-------LEYLDISNNNFSAL-----D 850
            |       |.:.|.|.|.:....|..|.|   |::|.|       |:.:::..||.:.|     |
  Rat   547 WKHANPGGPVNFLKGLSHLHILNLESNGL---DEIPVKVFKNLFELKSINLGLNNLNTLLPSIFD 608

  Fly   851 DR--VRGF-LQKRMNSSQLQLSLFG-------------NPWTCRCED-KDFLVFVKEQAKNIANA 898
            |:  :|.. |||.:.:| ::.|:||             ||:.|.||. ..|:.::.:...||...
  Rat   609 DQTSLRSLNLQKNLITS-VEKSVFGPAFHNLNSLDMSFNPFDCTCESIAWFVTWLNQTHTNIPEL 672

  Fly   899 SAIQCIDTGRSL----IEVEETDIC----PSVLIYY--TSLAVSLLIIALSINVFICFRQPIMIW 953
            |.....:|.:..    :::.:|..|    |..|::.  ||..::.::..|.|: |..:|    |.
  Rat   673 STHYLCNTPQRYHGLPVKLFDTSSCKDSAPFQLLFIINTSTLLTFILAVLLIH-FEGWR----IS 732

  Fly   954 FYEHEICLSLAARRELD---EDKKYDAFLSFTHKDEDLIEEFVDRLENGRHKFRLCFYLRDWLVG 1015
            ||.:.....:...:|:|   |..:|.|::....||.|.:.|....:|......:.|...||:..|
  Rat   733 FYWNVSVHRILGFKEIDAQGEQFEYTAYIIHAQKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAG 797

  Fly  1016 ESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLD 1080
            ....:.|..|:|.||:||.::|.:.||....|   |..:|...:...::             :||
  Rat   798 VLGLEAIVNSIKRSRKIIFVITHHLLKDPLCR---RFKVHHAVQQAIEQ-------------NLD 846

  Fly  1081 SELRAYMVLNTYLDRNNPNFWNKLMYSMPHASHLKR 1116
            |.:..::       :|.|:      |.:.||..|:|
  Rat   847 SIILIFL-------QNIPD------YKLNHALCLRR 869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 6/21 (29%)
leucine-rich repeat 388..408 CDD:275380 8/20 (40%)
LRR_8 412..465 CDD:290566 16/54 (30%)
leucine-rich repeat 412..432 CDD:275378 6/19 (32%)
LRR_4 432..470 CDD:289563 10/39 (26%)
leucine-rich repeat 433..454 CDD:275378 6/22 (27%)
leucine-rich repeat 455..478 CDD:275378 6/22 (27%)
leucine-rich repeat 479..490 CDD:275378 1/10 (10%)
leucine-rich repeat 632..657 CDD:275378 7/35 (20%)
leucine-rich repeat 658..679 CDD:275378 9/66 (14%)
leucine-rich repeat 680..706 CDD:275378 5/30 (17%)
leucine-rich repeat 707..719 CDD:275378 4/18 (22%)
leucine-rich repeat 771..791 CDD:275380 5/20 (25%)
leucine-rich repeat 793..815 CDD:275378 8/29 (28%)
leucine-rich repeat 816..835 CDD:275378 5/18 (28%)
leucine-rich repeat 836..859 CDD:275378 8/30 (27%)
TIR 974..1110 CDD:214587 30/135 (22%)
Tlr3NP_942086.2 leucine-rich repeat 37..53 CDD:275380 8/18 (44%)
leucine-rich repeat 54..77 CDD:275380 6/22 (27%)
PLN00113 66..>646 CDD:215061 125/629 (20%)
leucine-rich repeat 78..101 CDD:275380 6/22 (27%)
leucine-rich repeat 102..125 CDD:275380 6/24 (25%)
leucine-rich repeat 126..149 CDD:275380 6/39 (15%)
leucine-rich repeat 150..199 CDD:275380 14/55 (25%)
leucine-rich repeat 200..250 CDD:275380 7/53 (13%)
leucine-rich repeat 251..276 CDD:275380 4/24 (17%)
leucine-rich repeat 277..300 CDD:275380 2/22 (9%)
leucine-rich repeat 301..322 CDD:275380 4/20 (20%)
leucine-rich repeat 325..381 CDD:275380 7/55 (13%)
leucine-rich repeat 382..407 CDD:275380 3/24 (13%)
leucine-rich repeat 410..433 CDD:275380 6/26 (23%)
leucine-rich repeat 434..458 CDD:275380 6/23 (26%)
leucine-rich repeat 459..482 CDD:275380 2/22 (9%)
leucine-rich repeat 483..508 CDD:275380 6/24 (25%)
leucine-rich repeat 509..532 CDD:275380 5/22 (23%)
leucine-rich repeat 533..564 CDD:275380 10/42 (24%)
leucine-rich repeat 565..586 CDD:275380 6/23 (26%)
leucine-rich repeat 589..612 CDD:275380 6/22 (27%)
leucine-rich repeat 613..631 CDD:275380 6/18 (33%)
LRRCT 646..698 CDD:214507 11/51 (22%)
Tlr3_TMD 699..731 CDD:407816 8/36 (22%)
TIR 756..901 CDD:214587 34/143 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

Return to query results.
Submit another query.