DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and Tlr12

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001102152.1 Gene:Tlr12 / 362604 RGDID:1559145 Length:904 Species:Rattus norvegicus


Alignment Length:824 Identity:181/824 - (21%)
Similarity:283/824 - (34%) Gaps:245/824 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   410 SALVFQSNLLAELPD----NSLEGYHNLKSLDVSYNQLTSLSVSQLPESL-----HYLDIRHNKI 465
            |.|.....|....||    :|......||.||:|.||...::.   |.||     ..||:|..::
  Rat   175 SCLQDSGELAGIFPDLVQNSSSRASWTLKKLDLSLNQKLKMAT---PGSLQGLQVEILDLRKTQL 236

  Fly   466 TT-----LSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTI------ 519
            ..     |..|.:..||:.....:...:.:.:   :.||.        |.:..||...|      
  Rat   237 DAGAVKGLGLQKLNVLYAPTATAELAAETAAH---FELQG--------LNVDRSKIGNISQEALA 290

  Fly   520 ----MEYIELSSKG--SFVENFF--VQNIDQLYLEANE--------DEIIDAFGPSDKYFNLKLM 568
                :|.:.||..|  .....|.  :..:.:|.|..|:        :|..|..|.|    .|.| 
  Rat   291 SCHSLETLSLSDTGLTKLPPGFLAAMPRLRRLNLAGNQLQSTMLCMNETGDVSGLS----TLDL- 350

  Fly   569 EALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRN-LSLDIYPRLPNSIPYKT 632
                      ||....|:     .|..:.|..    |..|.|:.... |||:.:|.  ..:....
  Rat   351 ----------SGNGLRIL-----PPATFSCLP----HLRELLLQDNQLLSLEGHPF--QDLQQLE 394

  Fly   633 TLYLDRNEIRKL----------TNTESLVVA-----------GHASIHKLHMSQNLLRELPLHLL 676
            ||.||||.:..|          ..|.||:..           |..|:|.||:|...|....:..|
  Rat   395 TLKLDRNPLLNLGKNCLAALPALTTLSLLDTQILHSPDAGFWGARSLHTLHLSLPPLSAPAVLSL 459

  Fly   677 PENITYLDVR-NNLLKY--LDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEY 738
            |..:|.|::. ...||:  |...:..|||      .:.::|...:           |......|.
  Rat   460 PMYLTSLELHVTPGLKHWTLSPNIFPFLE------TLTINGRGLK-----------LGVQNASEV 507

  Fly   739 ETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLK 803
            ...|:.:.:..:..  |..|..|.|:.            .|.::|:|              .|||
  Rat   508 FPALQHLFLLQNSL--DAFCSQDASSI------------FLWQLPKL--------------QSLK 544

  Fly   804 KWPSS------LLPGYSSVTRFYLAHNRLSDIDQ------------LPDKLEYLDISNNNFSALD 850
            .|.:.      |:.|..|:....|  ..|..|.|            || :|:.|.:|:....:|.
  Rat   545 VWGAGSNSRPCLITGLPSLQELKL--ESLQSITQPRSVQLEELVGDLP-QLQALQLSSTGLKSLS 606

  Fly   851 DRVRGFLQKRMNSSQ-----------LQLSL-------------FGNPWTCRCEDKDFLVFVKEQ 891
              ...|  :|::|.|           ||.||             ..:...|:|.:....::||:.
  Rat   607 --AAAF--RRLHSLQALVLDSEKDLVLQDSLREYSPQMPRYVYILQSKLACQCANAWMELWVKQS 667

  Fly   892 AKNIAN-ASAIQCIDTGRSLIEVEET------DICPSVL---IYYTSLAVSLLIIALSI-----N 941
            .|...: .....|  .|...:...::      |.||..|   ::..|.|:.||:|.|.:     |
  Rat   668 TKTYVHIRDGHLC--PGEVRVPARDSLISFLWDHCPQTLELKLFLASSALVLLLIVLPLLQGARN 730

  Fly   942 VFICF-RQPIMIWFYEHEICLSLAARRELDEDKK--YDAFLSFTHKDED-LIEEFVDRLEN---- 998
            .:|.: |....||..        ..|.:.:..|:  :|.|:|...:|:. ::||.:..||.    
  Rat   731 TWIPYLRALFRIWLQ--------GLRGQGNAGKRFLFDVFVSHCRQDQGWVLEELLPALEGFLPA 787

  Fly   999 --GRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLA----LHAT 1057
              |   .|||...||:..|:.:.|.:..|:..||..:.:::...|.:....||.|||    |.|.
  Rat   788 GLG---LRLCLPERDFEPGKDVVDNVVDSMVSSRVTLCVLSGPALCNPRCCLELRLATSLLLAAP 849

  Fly  1058 SRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRNNPNFW 1101
            |..  ..|:|.|.|...|      :|.:|..|...|.|.:...|
  Rat   850 SPP--VLLLVFLEPISRH------QLPSYHRLARLLRRGDYCLW 885

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380
leucine-rich repeat 388..408 CDD:275380
LRR_8 412..465 CDD:290566 18/61 (30%)
leucine-rich repeat 412..432 CDD:275378 5/23 (22%)
LRR_4 432..470 CDD:289563 14/47 (30%)
leucine-rich repeat 433..454 CDD:275378 8/20 (40%)
leucine-rich repeat 455..478 CDD:275378 7/32 (22%)
leucine-rich repeat 479..490 CDD:275378 0/10 (0%)
leucine-rich repeat 632..657 CDD:275378 11/45 (24%)
leucine-rich repeat 658..679 CDD:275378 7/20 (35%)
leucine-rich repeat 680..706 CDD:275378 8/28 (29%)
leucine-rich repeat 707..719 CDD:275378 1/11 (9%)
leucine-rich repeat 771..791 CDD:275380 3/19 (16%)
leucine-rich repeat 793..815 CDD:275378 6/27 (22%)
leucine-rich repeat 816..835 CDD:275378 6/30 (20%)
leucine-rich repeat 836..859 CDD:275378 5/22 (23%)
TIR 974..1110 CDD:214587 39/141 (28%)
Tlr12NP_001102152.1 leucine-rich repeat 71..93 CDD:275380
leucine-rich repeat 94..116 CDD:275380
leucine-rich repeat 117..144 CDD:275380
leucine-rich repeat 202..225 CDD:275380 10/25 (40%)
leucine-rich repeat 226..270 CDD:275380 7/46 (15%)
leucine-rich repeat 246..259 CDD:275381 3/12 (25%)
LRR_8 270..329 CDD:290566 14/66 (21%)
leucine-rich repeat 271..294 CDD:275380 6/30 (20%)
LRR_4 294..331 CDD:289563 8/36 (22%)
leucine-rich repeat 295..318 CDD:275380 5/22 (23%)
leucine-rich repeat 319..344 CDD:275380 5/24 (21%)
LRR_8 343..403 CDD:290566 22/85 (26%)
LRR_RI 345..547 CDD:238064 56/272 (21%)
leucine-rich repeat 345..368 CDD:275380 8/46 (17%)
leucine-rich repeat 369..392 CDD:275380 6/24 (25%)
leucine-rich repeat 393..416 CDD:275380 7/22 (32%)
leucine-rich repeat 417..437 CDD:275380 3/19 (16%)
leucine-rich repeat 441..510 CDD:275380 18/85 (21%)
leucine-rich repeat 511..562 CDD:275380 14/78 (18%)
leucine-rich repeat 563..591 CDD:275380 6/30 (20%)
leucine-rich repeat 592..615 CDD:275380 6/26 (23%)
TIR 759..900 CDD:214587 39/138 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.020

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