DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and IL1R1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_000868.1	Gene:	IL1R1 / 3554	HGNCID:	5993	Length:	569	Species:	Homo sapiens

Alignment Length:	615	Identity:	114/615 - (18%)
Similarity:	222/615 - (36%)	Gaps:	204/615 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 CFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQ 665
            |.|......|::..| .:|:.|...|...:|.|:...:::.:...:||      .||  ::|..:
Human    23 CKEREEKIILVSSAN-EIDVRPCPLNPNEHKGTITWYKDDSKTPVSTE------QAS--RIHQHK 78

  Fly   666 NLLRELPLHLLPENITYLDVRN------------------NL-----------LKYLDDG--VIA 699
            ..|..:|..:......|..|||                  ||           |....||  |..
Human    79 EKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCP 143

  Fly   700 FLEYRENITKIELSGNPWECNCK------------------------------AKAFLSFLRRHE 734
            ::|:.:|... ||....|..:||                              ..|..::|.:..
Human   144 YMEFFKNENN-ELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQY 207

  Fly   735 PMEYETVLRRVEITDDKCPEDCICCVDTSN-------SDSLAYVVDCSGKELSEIPQLPTPTYGQ 792
            |:  ..|:..:.:.::|.....|  |..:|       ...:..:.:.:| :||:|
Human   208 PI--TRVIEFITLEENKPTRPVI--VSPANETMEVDLGSQIQLICNVTG-QLSDI---------- 257

  Fly   793 TTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFL 857
                    :..||..|::                 |.|......:|..:.|.     .::.|..|
Human   258 --------AYWKWNGSVI-----------------DEDDPVLGEDYYSVENP-----ANKRRSTL 292

  Fly   858 QKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNI--ANASAIQCI----DTGRSLIEVEET 916
            ...:|.|:::...:.:|:||             .|||.  .:|:.||.|    :..:.:|
Human   293 ITVLNISEIESRFYKHPFTC-------------FAKNTHGIDAAYIQLIYPVTNFQKHMI----- 339

  Fly   917 DICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSF 981
            .||.::.:          ||..|:.::..|:..|::|:  .:.|......:..| .|.|||::.:
Human   340 GICVTLTV----------IIVCSVFIYKIFKIDIVLWY--RDSCYDFLPIKASD-GKTYDAYILY 391

  Fly   982 -------THKDEDL-----IEEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIII 1034
                   :..|.|:     :.|.:::    :..::|..|.||..|||.|.:.||::||.|||:||
Human   392 PKTVGEGSTSDCDIFVFKVLPEVLEK----QCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLII 452

  Fly  1035 LMTKNFLKSTW--GRLEFRLALH-ATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRN 1096
            ::.:.....:|  |..|.::|:: |..:|..|.:::.| ..::.::.:...::       ::.:.
Human   453 ILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLEL-EKIQDYEKMPESIK-------FIKQK 509

  Fly  1097 N-----------------PNFWNKLMYSMP 1109
            :                 ..||..:.|.||
Human   510 HGAIRWSGDFTQGPQSAKTRFWKNVRYHMP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	3/24 (13%)
		leucine-rich repeat	658..679	CDD:275378	3/20 (15%)
		leucine-rich repeat	680..706	CDD:275378	11/56 (20%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	4/19 (21%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	2/18 (11%)
		leucine-rich repeat	836..859	CDD:275378	4/22 (18%)
		TIR	974..1110	CDD:214587	36/168 (21%)
IL1R1	NP_000868.1	Ig1_IL1R_like	24..113	CDD:319308	19/97 (20%)
		Ig2_IL1R_like	128..219	CDD:319309	15/93 (16%)
		IG	234..328	CDD:214652	24/147 (16%)
		TIR	384..540	CDD:214587	36/168 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910