Protein Alignment Toll-4 and fgfr2

DIOPT Version :9

• Sequence 1: NP_523519.2
• Gene: Toll-4 / 34235
• FlyBaseID: FBgn0032095
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: XP_005169609.1
• Gene: fgfr2 / 352940
• ZFINID: ZDB-GENE-030323-1
• Length: 836
• Species: Danio rerio
• Alignment Length: 384
• Identity: 77/384 - (20%)
• Similarity: 126/384 - (32%)
• Gaps: 147/384 - (38%)

  Fly   713 SGNP-----WECNCKAKAFLSFLRRHEPM-------EYETVLRRVEITDDKCPEDCICCVDTS-N 764
            :|||     |..|  ||.|    |:.:.|       ::.|::....:..||  .:..|.|:.. .
Zfish   205 AGNPKPKMRWLKN--AKPF----RQEDRMGGYKVRLQHWTLIMESVVPSDK--GNYTCLVENQYG 261

  Fly   765 SDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSV-----TRF----- 819
            |.:..|.:|                      |.||:..:....:.||...:|     .:|
Zfish   262 SINHTYTLD----------------------VVERSPHRPILQAGLPANVTVQVGQDAKFVCKVY 304

  Fly   820 --------YLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGN--- 873
                    :|.|...:.....||.|.|              ||......:|||.:::.:..|
Zfish   305 SDAQPHIQWLQHYTKNGSRYGPDGLPY--------------VRVLKSSGINSSDVEVLMLTNVTE 355

  Fly   874 ----PWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVE----ETDICPSVLIYYTSLA 930
                ..||:..:     ::.|     ||.|....:      |..|    |||..|.    |..:|
Zfish   356 EDAGEITCKVSN-----YIGE-----ANNSCWLIV------IPAETNPIETDYPPD----YVEIA 400

  Fly   931 V----SLLIIALSINVFIC-----------FRQPIMIWFYEHEICLSLAARRELDEDK------- 973
            :    ..||..:.:.|.:|           ..||.:     |::...:..||::..|.
Zfish   401 IYCIGVFLIACMVVIVVVCRMRTSAKKPDFSSQPAV-----HKLTKQIPLRRQVSSDSSSSMSSS 460

  Fly   974 ----KYDAFLSFTHKDEDLIEEFVDRLENGRHKFRLCFYLRDWL-VGESIPD-CINQSV 1026
                :.....|..|  :|.|.|: |..|:.|.:|.     ||.| :|:.:.: |..|.|
Zfish   461 TPLVRITTRRSSAH--DDPIPEY-DLPEDPRWEFS-----RDKLTLGKPLGEGCFGQVV 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378	4/10 (40%)
		leucine-rich repeat	771..791	CDD:275380	1/19 (5%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	5/36 (14%)
		leucine-rich repeat	836..859	CDD:275378	4/22 (18%)
		TIR	974..1110	CDD:214587	16/55 (29%)
fgfr2	XP_005169609.1	Ig	71..148	CDD:299845
		IG_like	75..148	CDD:214653
		Ig2_FGFR	187..271	CDD:143265	18/95 (19%)
		IG_like	197..271	CDD:214653	18/95 (19%)
		IG_like	286..380	CDD:214653	21/117 (18%)
		Ig	294..381	CDD:299845	19/116 (16%)
		PTKc_FGFR2	471..783	CDD:270679	16/49 (33%)
		Pkinase_Tyr	496..772	CDD:285015	5/16 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910