DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and CG18480

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	94/551 - (17%)
Similarity:	165/551 - (29%)	Gaps:	232/551 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 CIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSY 380
            |:.|....:.||....:..|.:..:.|          :|.....        :::.||..|:|..
  Fly     5 CVTKPKMWLGLKQILLYVGLLLCVLLQ----------VCRSKTQ--------SQMFCPTVCHCDL 51

  Fly   381 NRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTS 445
            :..:::..  |..|.|                 ..:|:  |:|.       .::.||:|||.:|:
  Fly    52 HAQRNRAV--CSAKRL-----------------ISANI--EIPT-------TVELLDLSYNDITT 88

  Fly   446 LSVSQLPESLHYLD--IRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKL 508
            :.......::|.|:  :.||.|.||                ||:.:                .:|
  Fly    89 IDDDSFKTTIHLLNLTLAHNAIHTL----------------YGDAF----------------VEL 121

  Fly   509 LRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNH 573
            .|::         |::||...       ::.||:..||:|..
  Fly   122 TRLR---------YLDLSYNR-------LEQIDEHILESNNQ----------------------- 147

  Fly   574 AIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDR 638
                         |.|||                                            |:.
  Fly   148 -------------LIHLN--------------------------------------------LEG 155

  Fly   639 NEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL---LPENITYLDVRNNLLKYLDDGVIAF 700
            |   ||:......:....|:..|::..:.:.:|...|   ||: :..||:..|||..|..|
  Fly   156 N---KLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQ-LRQLDLAQNLLLTLSPG---- 212

  Fly   701 LEYR--ENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTS 763
             ::.  .|:..:.:..||:.|:.......:.||:          |.|.|....|.|:   .|...
  Fly   213 -DFHAPRNLASLNVEENPFNCDRALAKVATGLRQ----------RGVAIFMSNCMEE---EVQDH 263

  Fly   764 NSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSD 828
            ..|:.|.......::...:..|...|.|              |.|:|    ||.|         |
  Fly   264 QDDAEAVNFPNKNEKFESMEYLEPSTRG--------------PQSVL----SVWR---------D 301

  Fly   829 IDQLPDKLEYLDISNNNFSALDDRVRGFLQK 859
            :|...::....|  :...|:|.|...|..:|
  Fly   302 LDSSEEQNSSQD--DEQMSSLSDVCEGSREK 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380	4/17 (24%)
		leucine-rich repeat	335..386	CDD:275380	7/50 (14%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		LRR_8	412..465	CDD:290566	13/54 (24%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	13/39 (33%)
		leucine-rich repeat	433..454	CDD:275378	6/20 (30%)
		leucine-rich repeat	455..478	CDD:275378	7/24 (29%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	4/24 (17%)
		leucine-rich repeat	658..679	CDD:275378	5/23 (22%)
		leucine-rich repeat	680..706	CDD:275378	7/27 (26%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	4/18 (22%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	20/114 (18%)
		LRR_RI	<76..230	CDD:238064	48/290 (17%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		leucine-rich repeat	100..123	CDD:275380	9/54 (17%)
		LRR_8	122..182	CDD:290566	19/158 (12%)
		leucine-rich repeat	124..147	CDD:275380	8/38 (21%)
		leucine-rich repeat	148..171	CDD:275380	8/69 (12%)
		LRR_8	170..230	CDD:290566	15/65 (23%)
		leucine-rich repeat	172..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..219	CDD:275380	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930