DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and CG16974

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	846	Identity:	161/846 - (19%)
Similarity:	277/846 - (32%)	Gaps:	300/846 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 LKDLSFLRSSTLQSSLTYCIMKVDNMVDL-----KSFEKFTNLEIIEVSQYKGFKNFTAFICEPY 357
            |..|..||..:.|||    .:|.:.:::|     :|||....|.:.|          ....|
  Fly   170 LPQLESLREFSWQSS----ELKDETLMELFTRQPRSFEYMERLNLAE----------NRLEC--- 217

  Fly   358 KSHCKFTLGINEVA-----------CPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSA 411
             .|....|.:..|.           |.| .|..|.:...:|.:|  :..||.:|...:.:.....
  Fly   218 -LHWAIPLAVRRVKVLEMSGNRLSNCSL-LNLQYMKQLQELHLD--RSELTYLPQRFLGELSELR 278

  Fly   412 LV-FQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSL--SVSQLPESLHYLDIRHNKITTLSPQVV 473
            :: ...|||.|||.:...|...|:.|.:|.|:|:.|  .:.|....|..||:..|::.:
  Fly   279 MLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLS------ 337

  Fly   474 EYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQ 538
               :..|.|.:.|.     ..:.|||.                      .:|.|.|.. ..:.::
  Fly   338 ---FPDNFFARNGQ-----LRQLHLQR----------------------NQLKSIGKH-SLYSLR 371

  Fly   539 NIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWL-FSGE----FDEIILHHLNSPCPYRC 598
            .:.||.|..|...:||.          |..|:|:|.:.| .||.    ...||...|::
  Fly   372 ELRQLDLSQNSLSVIDR----------KAFESLDHLLALNVSGNNLTLLSSIIFQSLHA------ 420

  Fly   599 SCCFEWHTGEFLINCRNLSLDIYPRLPNSI-------------------------PYKTTL---- 634
                        :...:||.:.:.:||:.:                         .|..:|
  Fly   421 ------------LRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQ 473

  Fly   635 ------YLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLP-ENITYLDVRNNLLKY 692
                  ||...:.||||...:.:.|...:|.:|.:::|.|.:||..:.. ..:..|.||.|.|..
  Fly   474 VLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQISGLSRLQRLSVRGNSLGS 538

  Fly   693 LDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCI 757
            |.:.:   .|.|: :..:.:.||.::|:|......::|
  Fly   539 LPENI---KELRQ-LHYLNILGNEYQCDCSMYWLTAWL--------------------------- 572

  Fly   758 CCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLA 822
                .:.|.||.:          ::||....:.|.|.            .:.|..|.|:..
  Fly   573 ----ANTSTSLRH----------QMPQAQNHSNGSTN------------QTPLDSYESIDH---- 607

  Fly   823 HNRLSDIDQLP-------DKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNP-----W 875
                 .||.|.       |.|..|...|.:...:.......:.|.:::::|:..:.|:|     |
  Fly   608 -----QIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLLSTAKLECQISGSPVPDIIW 667

  Fly   876 T----------CRCEDKDFLVFVKEQAKN---------IANASAIQCID-------TGRSLIEVE 914
            .          ...:.:..::..||.|..         :.:.|.||.::       .||.::.||
  Fly   668 VTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLVE 732

  Fly   915 ETDICPSVLIYYTSLAVSLLIIALSINV-------FICFRQPIMIWFYEHEI-----CLSLAARR 967
            .    .|:|::..|...|.|....:.||       ...:..||:  ||..:|     ..:||.
  Fly   733 N----GSLLVHNISRIDSGLYTCYAFNVMGKASAGLRLYIDPIV--FYRVKIGSILFGTALAT-- 789

  Fly   968 ELDEDKKYDAFLSFTHKDEDLIEEFVDRLENGRHKFRLC--FYLRDWLVGESIPDCINQSVKGSR 1030
                     |||        |:...|..|.:...::.:|  ||.           |:|:..|..|
  Fly   790 ---------AFL--------LLTLIVQGLRSCLSRWGICNRFYC-----------CVNRKKKSPR 826

  Fly  1031 R 1031
            :
  Fly   827 K 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380	4/9 (44%)
		leucine-rich repeat	309..334	CDD:275380	8/29 (28%)
		leucine-rich repeat	335..386	CDD:275380	10/61 (16%)
		leucine-rich repeat	388..408	CDD:275380	4/19 (21%)
		LRR_8	412..465	CDD:290566	18/55 (33%)
		leucine-rich repeat	412..432	CDD:275378	7/20 (35%)
		LRR_4	432..470	CDD:289563	11/39 (28%)
		leucine-rich repeat	433..454	CDD:275378	7/22 (32%)
		leucine-rich repeat	455..478	CDD:275378	4/22 (18%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	8/34 (24%)
		leucine-rich repeat	658..679	CDD:275378	6/21 (29%)
		leucine-rich repeat	680..706	CDD:275378	8/25 (32%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	3/25 (12%)
		leucine-rich repeat	836..859	CDD:275378	3/22 (14%)
		TIR	974..1110	CDD:214587	13/60 (22%)
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	5/35 (14%)
		leucine-rich repeat	229..252	CDD:275380	5/23 (22%)
		LRR_RI	<246..433	CDD:238064	52/253 (21%)
		LRR_8	251..311	CDD:290566	16/61 (26%)
		leucine-rich repeat	253..276	CDD:275380	5/24 (21%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	17/94 (18%)
		leucine-rich repeat	325..348	CDD:275380	6/31 (19%)
		leucine-rich repeat	349..372	CDD:275380	6/45 (13%)
		LRR_RI	351..>557	CDD:238064	49/260 (19%)
		LRR_8	371..431	CDD:290566	18/87 (21%)
		leucine-rich repeat	373..396	CDD:275380	9/32 (28%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	4/22 (18%)
		LRR_8	477..536	CDD:290566	17/58 (29%)
		leucine-rich repeat	478..502	CDD:275380	7/23 (30%)
		leucine-rich repeat	503..526	CDD:275380	6/22 (27%)
		Ig	<714..761	CDD:299845	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453750
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930