back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr9

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_937764.1	Gene:	Tlr9 / 338457	RGDID:	631352	Length:	1032	Species:	Rattus norvegicus

Alignment Length:	1226	Identity:	248/1226 - (20%)
Similarity:	446/1226 - (36%)	Gaps:	422/1226 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PEVRERRFKWTSDGQQQQQQQLGWCNNKDDPPNSHQKSKSNNDARNLNSRVRVRARVRVVPG--- 72
            |.||:...||.             |    .||..              |.:....|:.:.|.
  Rat    87 PNVRQLNLKWN-------------C----PPPGL--------------SPLHFSCRMTIEPKTFL 120

  Fly    73 EMRM-GDINCS-NGLGNIREDYCEIYLDELGENGT-CSIANNEVTTED-------YQMKLVFLKL 127
            .||| .::|.| ||:..:         ..|..:.| .|:::..:...|       :.::::|:..
  Rat   121 AMRMLEELNLSYNGITTV---------PRLPSSLTNLSLSHTNILVLDASSLAGLHSLRVLFMDG 176

  Fly   128 EINWTSPVFHGWNI-----FKICNETDYELVIISVLGIRSEVDMRISPAVQYLSL-------LGI 180
            ...:.:|.....|:     ..:.|.|...|...::    :||..::.|:::||.|       ||.
  Rat   177 NCYYKNPCNGAVNVTPDAFLGLSNLTHLSLKYNNL----TEVPRQLPPSLEYLLLSYNLIVKLGP 237

  Fly   181 REISG------YDI--------YLPSVLITE-----MDVHHANGPKMVTFKYLYDSTVNSVITNN 226
            .:::.      .|:        :.|. |.||     :|:|    |:  ||.:|  |.:..::..:
  Rat   238 EDLANLTSLRVLDVGGNCRRCDHAPD-LCTECRQKSLDLH----PQ--TFHHL--SHLEGLVLKD 293

  Fly   227 YIRKTMNNTEKIKIYYHNTFEKTTLTMEKN-IFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNT 290
            ....::|:.     ::......:.|.:.:| ::...||.||               |:|||.|..
  Rat   294 SSLHSLNSK-----WFQGLVNLSVLDLSENFLYESINKTSA---------------FQNLTRLRK 338

  Fly   291 LIFDNVFLKDLSFLR---SSTLQS----------SLTYCIMKVDNMVDLKSFEKFTNLEI----I 338
            |.....:.|.:||.|   :|:.:|          .:.:.::..:.:..|....|...|.:    |
  Rat   339 LDLSFNYCKKVSFARLHLASSFKSLVSLQELNMNGIFFRLLNKNTLRWLAGLPKLHTLHLQMNFI 403

  Fly   339 EVSQYKGFKNFTAFICEPYKSHCKFT-LGINEVACP--LKCNCSYNRDKSQLEIDCWQKNLT-TI 399
            ..:|...|..|.|.         :|. |..|.::.|  |........|:::..:. |..:|| .:
  Rat   404 NQAQLSVFSTFRAL---------RFVDLSNNRISGPPTLSRVAPEKADEAEKGVP-WPASLTPAL 458

  Fly   400 PSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLK-SLDVSYNQLTSLSVSQLPESLHYLDIRHN 463
            ||.||.|                  |.:....||: ::|:|.|.|.::.    ||.  ::::.|.
  Rat   459 PSTPVSK------------------NFMVRCKNLRFTMDLSRNNLVTIK----PEM--FVNLSHL 499

  Fly   464 KITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSK 528
            :..:||...:....:.:.|....|                  .|:|.:..:|       ::|...
  Rat   500 QCLSLSHNCIAQAVNGSQFLPLTN------------------LKVLDLSYNK-------LDLYHS 539

  Fly   529 GSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSP 593
            .||.|...:|.:|..|              :.:.|:   |:.:.|.   ||
  Rat   540 KSFSELPQLQALDLSY--------------NSQPFS---MQGIGHN---FS-------------- 570

  Fly   594 CPYRCSCCFEWHTGEFLIN---CRNLSL---DIYPRLPNSIPYKTTL-YLD--RNEIRKLTNTES 649
                           ||.|   .:||||   ||:.|:.:.: |.|:: |||  .|.:.::.:.|.
  Rat   571 ---------------FLANLSRLQNLSLAHNDIHSRVSSRL-YSTSVEYLDFSGNGVGRMWDEED 619

  Fly   650 LVV---AGHASIHKLHMSQN---LLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENIT 708
            |.:   ....|:..|.:|||   :||...|:.||:::|.|..|:|.|.:.:...:|||   .|:.
  Rat   620 LYLYFFQDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRDNHLSFFNWSSLAFL---PNLR 681

  Fly   709 KIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVD 773
            .::|:||          .|..| .:..:...|:|:::::                :|:|:.:||.
  Rat   682 DLDLAGN----------LLKAL-TNGTLPNGTLLQKLDV----------------SSNSIVFVVP 719

  Fly   774 ---CSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQ---- 831
               ....||.|:                                     .|:||.|..:|:
  Rat   720 AFFALAVELKEV-------------------------------------NLSHNILKTVDRSWFG 747

  Fly   832 -LPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDK--DFLVFVKEQAK 893
             :...|..||:|:                             ||..|.|...  |.|:.|:.:..
  Rat   748 PIVMNLTVLDVSS-----------------------------NPLHCACGAPFVDLLLEVQTKVP 783

  Fly   894 NIANASAIQCID----TGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIM--- 951
            .:||  .::|..    .|||:. .::..:|...::......:|||.:|:...:      |::
  Rat   784 GLAN--GVKCGSPRQLQGRSIF-AQDLRLCLDDVLSRDCFGLSLLAVAVGTVL------PLLQHL 839

  Fly   952 ----IWFYEHEICLS----LAARRELDEDKKYDAFLSFTHKDEDLIEEFV-----DRLE--NGRH 1001
                :|:..| :||:    |...|...:...||||:.| .|.:..:.::|     .|||  .||.
  Rat   840 CGWDVWYCFH-LCLAWLPLLTRGRRSAQALPYDAFVVF-DKAQSAVADWVYNELRVRLEERRGRR 902

  Fly  1002 KFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLI 1066
            ..|||...||||.|:::.:.:..|:.|||:.:.::......|...|..|.||......||...::
  Rat   903 ALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDKVSGLLRTSFLLAQQRLLEDRKDVVV 967

  Fly  1067 -VVLYPDV--EHFDDLDSELRAYMV----------------LNTYLDRNNPNFWNK 1103
             |:|.||.  ..:..|...|....|                |:|.|.|:|.:|:|:
  Rat   968 LVILRPDAHRSRYVRLRQRLCRQSVLFWPHQPNGQGSFWAQLSTALTRDNHHFYNR 1023

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.