DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and Tlr7

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:XP_017457568.1 Gene:Tlr7 / 317468 RGDID:1563357 Length:1068 Species:Rattus norvegicus


Alignment Length:1223 Identity:260/1223 - (21%)
Similarity:446/1223 - (36%) Gaps:434/1223 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LNSRVRV-RARVRVVPGEMRMGDINCSNGLGNIREDYCEIYLDELGENGTCSIANNEV--TTEDY 118
            |.|:..| ..|:::.||..        :||.:::    .:|||           .|::  ..:|.
  Rat   123 LGSKANVCTKRLQIRPGSF--------SGLSDLK----SLYLD-----------GNQLLEIPQDL 164

  Fly   119 QMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVIISVLGIRSEVDMR----ISPAVQ---YLS 176
            ...|..|.||.|         |||.|..|...|||.|..|.:......|    :|.:::   :|.
  Rat   165 PSSLQLLSLEAN---------NIFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLV 220

  Fly   177 LLGIREISGYD---IYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKI 238
            :..::.:|..|   ..:|::|           |..:...|||         ||.|::...     
  Rat   221 MKNLKVLSLKDNNVTAVPTIL-----------PPNLLELYLY---------NNIIKRIQE----- 260

  Fly   239 KIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNN------------TFENLTSLNTL 291
                                |..||:|.     |::..|:.|            ..||.:.|.  
  Rat   261 --------------------HDFNKLSQ-----LQVLDLSGNCPRCYNVPYPCTPCENNSPLQ-- 298

  Fly   292 IFDNVF--LKDLSFLR--SSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAF 352
            |.||.|  |.:|..||  |::||.            |..:.|:..:||:.:::||     |:.|.
  Rat   299 IHDNAFDSLTELKVLRLHSNSLQH------------VPAEWFKNMSNLQELDLSQ-----NYLAR 346

  Fly   353 ICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSN 417
            ..|    ..||   :|.:...::.:.|:|     .|:..:..::|...||       |:|....|
  Rat   347 EIE----EAKF---LNSLPNLVQLDLSFN-----YELQVYHASITLPHSL-------SSLTKLKN 392

  Fly   418 L------LAELPDNSLEGYHNLKSLDV-----SYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQ 471
            |      ..||.|:||...|||.:|:|     ::.::..|::.|..|:|.::|:..|||   ||.
  Rat   393 LYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKIADLNIFQQFENLKFIDLSVNKI---SPS 454

  Fly   472 VVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFF 536
                                                                             
  Rat   455 ----------------------------------------------------------------- 454

  Fly   537 VQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCC 601
             :...::.|..|....:|..||       :::|||::.      .:||           |..||.
  Rat   455 -EESREVGLCPNAQTSVDWHGP-------QVLEALHYF------RYDE-----------YARSCR 494

  Fly   602 FEWHTGEFLINCRNLSLDIYPRLPNSIP-------YKTTLYLDRNEI--------RKLTNTESLV 651
            |:                 ....|..:|       |..||.|.||.|        :.|:..:.|.
  Rat   495 FK-----------------NKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLN 542

  Fly   652 VAGHASIHKLHMSQ-NLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGN 715
            ::|:|....|:.|: ..||||         .|||..||.|..|..  .|| |..:|:..::||.|
  Rat   543 LSGNAIGQTLNGSELQPLREL---------RYLDFSNNRLDLLYS--TAF-EELQNLEILDLSSN 595

  Fly   716 PWECNCKA-KAFLSFLR--RHEPMEYETVLRRVEITDDKCPEDCICCVDTS-----NSDSLAYV- 771
            ......:. ...|:|.:  ||        |.::.:.|:.        :.||     .|:||..: 
  Rat   596 SHYFQAEGITHMLNFTKKLRH--------LEKLMMNDND--------ISTSASRTMESESLRVLE 644

  Fly   772 -----------------------------VDCSGKELSEIPQLPTPTYGQ----TTLVFERNSLK 803
                                         :|.|...|:.:|  |....|.    |||...:|.|:
  Rat   645 FRGNHLDVLWRDGDNRYLDFFKNLLNLEELDISRNSLNSVP--PGVFEGMPPNLTTLSLAKNGLR 707

  Fly   804 --KW----------------------PSSLLPGYSSVTRFYLAHNRLSDIDQ--LPD--KLEYLD 840
              .|                      |:.|.....|:|:..|.||::..:.:  |.|  :|.|||
  Rat   708 SFSWGRLQLLKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDALQLRYLD 772

  Fly   841 ISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIAN-ASAIQC- 903
            ||:|....:  :...|.:..:|:..: |.|..|.:.|.|:...|:.:|......|.. |:.:.| 
  Rat   773 ISSNKIQVI--QKTSFPENVLNNLNM-LLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCA 834

  Fly   904 ---IDTGRSLIEVE----ETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWF------- 954
               ...|:|:|.::    |.|:...:|...:..:|..|:|.::.:....:....:.:|       
  Rat   835 GPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMIVMTTSHLFFWDMWYIYYFWKAKIKG 899

  Fly   955 YEH----EICLSLAARRELDEDKKYDAFLSFTHKD----EDLIEEFVDRLENGRHK-FRLCFYLR 1010
            |:|    |.|              ||||:.:..|:    |.:::|.|.:||:.|.| |.||...|
  Rat   900 YQHLQSMESC--------------YDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLCLEER 950

  Fly  1011 DWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEH 1075
            |||.|:.:.:.::||::.||:.:.:||:.:.|:...::.|.|: |....|....:|::::.:...
  Rat   951 DWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTESFKMAFYLS-HQRLMDEKVDVIILIFLEKPL 1014

  Fly  1076 FDDLDSELRAYMVLNTYLD-----RNNPNFWNKLMYSMPHASHLKRSRSDAET 1123
            ......:||..:..::.|:     :.:|.||..|..::...:|:..|:...||
  Rat  1015 QKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNALTTDNHVAYSQMFKET 1067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 6/34 (18%)
leucine-rich repeat 288..308 CDD:275380 10/23 (43%)
leucine-rich repeat 309..334 CDD:275380 4/24 (17%)
leucine-rich repeat 335..386 CDD:275380 11/50 (22%)
leucine-rich repeat 388..408 CDD:275380 4/19 (21%)
LRR_8 412..465 CDD:290566 19/63 (30%)
leucine-rich repeat 412..432 CDD:275378 8/25 (32%)
LRR_4 432..470 CDD:289563 12/42 (29%)
leucine-rich repeat 433..454 CDD:275378 5/25 (20%)
leucine-rich repeat 455..478 CDD:275378 7/22 (32%)
leucine-rich repeat 479..490 CDD:275378 0/10 (0%)
leucine-rich repeat 632..657 CDD:275378 9/32 (28%)
leucine-rich repeat 658..679 CDD:275378 6/21 (29%)
leucine-rich repeat 680..706 CDD:275378 10/25 (40%)
leucine-rich repeat 707..719 CDD:275378 3/11 (27%)
leucine-rich repeat 771..791 CDD:275380 5/49 (10%)
leucine-rich repeat 793..815 CDD:275378 8/45 (18%)
leucine-rich repeat 816..835 CDD:275378 6/22 (27%)
leucine-rich repeat 836..859 CDD:275378 8/22 (36%)
TIR 974..1110 CDD:214587 39/145 (27%)
Tlr7XP_017457568.1 leucine-rich repeat 66..87 CDD:275380
LRR_8 93..157 CDD:290566 12/56 (21%)
leucine-rich repeat 109..146 CDD:275380 8/30 (27%)
leucine-rich repeat 147..191 CDD:275380 17/67 (25%)
leucine-rich repeat 192..223 CDD:275380 5/30 (17%)
LRR_8 222..277 CDD:290566 17/104 (16%)
LRR_RI 223..472 CDD:238064 76/405 (19%)
leucine-rich repeat 224..244 CDD:275380 5/30 (17%)
leucine-rich repeat 245..268 CDD:275380 9/56 (16%)
leucine-rich repeat 269..309 CDD:275380 11/41 (27%)
LRR_8 308..368 CDD:290566 19/83 (23%)
leucine-rich repeat 310..333 CDD:275380 8/34 (24%)
leucine-rich repeat 334..359 CDD:275380 9/36 (25%)
leucine-rich repeat 370..389 CDD:275380 6/25 (24%)
leucine-rich repeat 390..416 CDD:275380 10/25 (40%)
leucine-rich repeat 417..440 CDD:275380 4/22 (18%)
LRR_8 515..573 CDD:290566 21/66 (32%)
leucine-rich repeat 515..537 CDD:275380 7/21 (33%)
LRR_RI 532..778 CDD:238064 63/275 (23%)
leucine-rich repeat 538..562 CDD:275380 6/23 (26%)
LRR_8 561..627 CDD:290566 23/93 (25%)
leucine-rich repeat 563..586 CDD:275380 11/34 (32%)
leucine-rich repeat 587..616 CDD:275380 5/28 (18%)
leucine-rich repeat 617..639 CDD:275380 5/29 (17%)
LRR_8 639..706 CDD:290566 12/68 (18%)
leucine-rich repeat 640..670 CDD:275380 1/29 (3%)
leucine-rich repeat 671..695 CDD:275380 6/25 (24%)
LRR_8 694..754 CDD:290566 13/59 (22%)
leucine-rich repeat 696..719 CDD:275380 6/22 (27%)
leucine-rich repeat 720..743 CDD:275380 2/22 (9%)
leucine-rich repeat 768..786 CDD:275380 7/19 (37%)
TIR 909..1054 CDD:214587 40/159 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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