DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr13

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_038956543.1	Gene:	Tlr13 / 317227	RGDID:	1562655	Length:	956	Species:	Rattus norvegicus

Alignment Length:	1110	Identity:	227/1110 - (20%)
Similarity:	391/1110 - (35%)	Gaps:	358/1110 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 ISPAVQY------LSLLGIREISGYDIYLPSVLITEMDVHH--------ANGPKMVTFKYLYDST 218
            :.|::|.      ||||.:.|..|::    .....|.|:||        .|..:.::....|.:.
  Rat    12 VVPSLQLLLMLIGLSLLSLAETYGFN----KCTQYEFDIHHVFCIRKKITNLTEAISDIPRYTTH 72

  Fly   219 VNSVITNNYIRK----TMNNTEKIKIYYHNTFEKTTLTMEKNI--------FHGKNKMSALIFNG 271
            :|  :|||||:.    :..|...:          ..|.:|.|:        |.|...::.|....
  Rat    73 LN--LTNNYIQVLPPWSFTNLSAL----------VDLRLEWNLIWKIDEGAFRGLENLTLLNLVE 125

  Fly   272 LKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLE 336
            .||:.: ||:||.|::|.||:..:               :.:|:        :...:|.....|:
  Rat   126 NKIQSV-NNSFEGLSNLETLLLSH---------------NQITH--------IHKDAFTPLVKLK 166

  Fly   337 IIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLE-IDCWQKNLTTIP 400
            .:.:|:.: ..||:               ||.|....|.|          || :|....::..:.
  Rat   167 YLSLSRNR-ISNFS---------------GILEAVQHLPC----------LEHLDLINNSIMYLD 205

  Fly   401 SLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYN--------------QLTSLSVSQL 451
            ..|......:.|.|:.|.|.||..::| ...||.:|..|.|              ||.||::|..
  Rat   206 HSPRSLVSLTHLSFEGNNLTELNFSTL-SLPNLTNLSASQNGHGVIQDVYLKTLPQLQSLNLSGT 269

  Fly   452 PESLHYLDIRH-------------NKITTLSPQVVEYL-----------YSVNVFNQYGNKWSIY 492
            ...|..|..:|             .|...|:.::|.||           :..|..|..|.|....
  Rat   270 VVKLEMLSAKHLQNVRVMDLSNRELKHGHLNMKIVCYLLRNLPMLEILFFHKNATNAEGIKQLAK 334

  Fly   493 CDEYHLQEFFWYKAKLLRIKTSKFQTI--MEYIELSS-KGSFVEN---FFVQNIDQLYLEANEDE 551
            |......: ....:.|:.:..|:|..:  ::.:.|:. :.||:.|   ..:||:..|.|..|:.:
  Rat   335 CTRLLFLD-LGQNSDLVHLNDSEFNALPSLQRLNLNKCQLSFISNKTWSSLQNLTILDLSHNKFK 398

  Fly   552 IID--AFGPSDKYFNLKL----MEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFL 610
            ...  ||.|..:...|.|    :..||:.  .|||.|.   |..||                  |
  Rat   399 SFPDFAFSPLKRLEFLSLSRNPITELNNL--AFSGLFS---LKELN------------------L 440

  Fly   611 INCRNLSLDIY--PRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHAS------IHKLHMSQNL 667
            ..|..:::|.|  .:.||    ...|.|..|.||.|         .|.:      :|.|.:|.|
  Rat   441 AACWIVTIDRYSFTQFPN----LEVLDLGDNNIRTL---------NHGTFQPLKKLHTLILSHN- 491

  Fly   668 LRELPLHLLPEN-------ITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKA 725
                .|.::..|       :.|||:..|.|.|........|   |.:..::|..|
  Rat   492 ----RLEIMESNAFSGLTGLRYLDLMYNSLSYFHKHHFMGL---EKLLVLKLGFN---------- 539

  Fly   726 FLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTY 790
                     .:.|||.                                   :.|...|.:...:.
  Rat   540 ---------KITYETT-----------------------------------RTLQYPPFMKLKSL 560

  Fly   791 GQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHN--------------RLSDID----------- 830
            .|..|..:::.::..|.:...|.||:....|..|              .|:.:|
  Rat   561 KQLNLEGQKHGIQVVPRNFFQGLSSLQELLLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSL 625

  Fly   831 -------QLPDKLEYLDISNNNFSALDDRVRGFLQ------------KRMNSSQLQ-------LS 869
                   |...:|:.|.:.|||..:|...:...||            |.:|.|.|:       ..
  Rat   626 YLNSSLFQNLKRLKVLRLENNNLESLVPGMFSSLQNLQVFSLRFNNLKVINQSHLENLKSLMFFD 690

  Fly   870 LFGNPWTCRCEDKDF-----------LVFVKEQAKNIANASAIQCIDTGRSLIEVEETDICPSVL 923
            ::||...|.|::..|           :.|::.......|:.::        ||:.::. :|...|
  Rat   691 VYGNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPNSQSL--------LIDFDDA-MCNFDL 746

  Fly   924 --IYYTSLAVSLLIIALSINVFICFRQPIM--IWFYEHEICLSLAARRELDEDKK--YDAFLSFT 982
              :|:    :....:.||..||..|...::  :| |...||.:....:....:||  ||||:||:
  Rat   747 GKVYF----LCSFSVVLSTMVFSWFSAKMIASLW-YGLYICRAWYLTKWHKTEKKFLYDAFVSFS 806

  Fly   983 HKDEDLI-EEFVDRLENG-RHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTW 1045
            ..||..: :|.|..||.| :..|:||.:.||:..|..|.:.|..::..||:.:.:::.::|.|.|
  Rat   807 ATDEAWVYKELVPALEEGSQTTFKLCLHQRDFEPGIDIFENIQNAINASRKTLCVVSNHYLHSEW 871

  Fly  1046 GRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDR-----------NNPN 1099
            .|||.:||......:....:|::...::.::     :|.:|..|...::|           ..|.
  Rat   872 CRLEVQLASMKMFYEHKDVIILIFLEEIPNY-----KLSSYHRLRKLINRQTFITWPDSAHQQPL 931

  Fly  1100 FWNKL 1104
            ||.::
  Rat   932 FWARI 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/22 (36%)
		leucine-rich repeat	288..308	CDD:275380	3/19 (16%)
		leucine-rich repeat	309..334	CDD:275380	2/24 (8%)
		leucine-rich repeat	335..386	CDD:275380	9/50 (18%)
		leucine-rich repeat	388..408	CDD:275380	3/20 (15%)
		LRR_8	412..465	CDD:290566	20/79 (25%)
		leucine-rich repeat	412..432	CDD:275378	7/19 (37%)
		LRR_4	432..470	CDD:289563	15/64 (23%)
		leucine-rich repeat	433..454	CDD:275378	9/34 (26%)
		leucine-rich repeat	455..478	CDD:275378	8/46 (17%)
		leucine-rich repeat	479..490	CDD:275378	4/10 (40%)
		leucine-rich repeat	632..657	CDD:275378	7/24 (29%)
		leucine-rich repeat	658..679	CDD:275378	5/20 (25%)
		leucine-rich repeat	680..706	CDD:275378	7/25 (28%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	5/50 (10%)
		leucine-rich repeat	836..859	CDD:275378	8/34 (24%)
		TIR	974..1110	CDD:214587	40/146 (27%)
Tlr13	XP_038956543.1	leucine-rich repeat	47..69	CDD:275380	3/21 (14%)
		leucine-rich repeat	70..93	CDD:275380	7/24 (29%)
		PLN00113	72..>518	CDD:215061	117/550 (21%)
		leucine-rich repeat	94..117	CDD:275380	5/32 (16%)
		leucine-rich repeat	118..140	CDD:275380	8/22 (36%)
		leucine-rich repeat	141..164	CDD:275380	5/45 (11%)
		leucine-rich repeat	165..190	CDD:275380	8/40 (20%)
		leucine-rich repeat	191..213	CDD:275380	4/21 (19%)
		leucine-rich repeat	214..236	CDD:275380	7/22 (32%)
		leucine-rich repeat	237..260	CDD:275380	4/22 (18%)
		leucine-rich repeat	261..283	CDD:275380	7/21 (33%)
		leucine-rich repeat	338..362	CDD:275380	3/24 (13%)
		PLN00113	360..>710	CDD:215061	85/447 (19%)
		leucine-rich repeat	363..386	CDD:275380	4/22 (18%)
		leucine-rich repeat	387..410	CDD:275380	6/22 (27%)
		leucine-rich repeat	411..434	CDD:275380	7/24 (29%)
		leucine-rich repeat	435..458	CDD:275380	7/40 (18%)
		leucine-rich repeat	459..482	CDD:275380	7/31 (23%)
		leucine-rich repeat	483..506	CDD:275380	6/27 (22%)
		leucine-rich repeat	507..530	CDD:275380	7/25 (28%)
		leucine-rich repeat	531..585	CDD:275380	11/107 (10%)
		leucine-rich repeat	638..661	CDD:275380	7/22 (32%)
		leucine-rich repeat	662..683	CDD:275380	4/20 (20%)
		TIR	799..943	CDD:214587	39/143 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920