DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_038947853.1	Gene:	Tlr1 / 305354	RGDID:	1309975	Length:	808	Species:	Rattus norvegicus

Alignment Length:	886	Identity:	188/886 - (21%)
Similarity:	327/886 - (36%)	Gaps:	253/886 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 HCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELP 423
            :|...||:..:...|.       ::|:|.|.....|||.:| .||:.   ::.|....|.::||.
  Rat    23 YCIVVLGLILIKIQLS-------EESELIIKRPNANLTRVPKDLPLQ---TTTLDVSQNNISELQ 77

  Fly   424 DNSLEGYHNLKSLDVSYNQLTSLSVS--QLPESLHYLDIRHNKITTLSPQVVEYL----YSVNVF 482
            .:.:.....|:...:|||:|..|::|  :....|.|||:.||::..:|......|    .|.|.|
  Rat    78 TSDILLLSKLRVFIMSYNRLQYLNISVFKFNTELEYLDLSHNELRLISCHATADLKHLDLSFNAF 142

  Fly   483 NQYGNKWSIYCDEY-HLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLE 546
            :...     .|.|: :|.:..:......:|:.|..| ::.::.:|.....:.:.:.:..|...|:
  Rat   143 DALP-----ICKEFGNLSQLQFLGLSGSQIQNSSVQ-LIAHLNISKVLLVLGDTYGEKEDPKCLQ 201

  Fly   547 ANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEI--ILHHLNSPCPYRCSCCFEWHTGEF 609
            ....|.:....||.:.|:..|..:::.||.|   |...|  :|...|        |.:...|.|.
  Rat   202 HISTETLHIVFPSKREFHFLLDMSVSTAISL---ELSNIKCVLEDKN--------CSYFLGTLER 255

  Fly   610 LINCR---NLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLREL 671
            |...:   ||:|:......||  :...|.|..:...|..:..::.:.||.:..:.|.|...||.|
  Rat   256 LRKTQRLSNLTLNNVDTTWNS--FINILQLVWHTPVKSFSISNVKLKGHFNFRRFHYSDTSLRAL 318

  Fly   672 PLH------------------------------------LLPENIT---YLDVRNNLLKYLDDGV 697
            .:|                                    |.|:.|:   |||..:|||.     .
  Rat   319 SIHQVVTDVFSFPQSNIYSIFSNMNIQSFTVSGTRMVHMLCPDQISPFLYLDFTDNLLT-----D 378

  Fly   698 IAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYET-VLRRVEITDDKCPEDCICCVD 761
            |.|.:.|..|....||                |::::....|. :|..:|:|.       :..:|
  Rat   379 IVFEDCRNLIRLKTLS----------------LQKNQLKTLENIILMSMEMTS-------LQKLD 420

  Fly   762 TSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRL 826
            .| .:||.|                          .:..|...|..|||.       ..|:.|.|
  Rat   421 IS-QNSLRY--------------------------SDAGSPCSWTQSLLV-------LNLSSNML 451

  Fly   827 SD--IDQLPDKLEYLDISNNN--------------------------------FSALDDRV---- 853
            :|  ...||.|::.||:.||.                                ||:|...|
  Rat   452 TDSVFRCLPPKVKVLDLHNNRIVSISKDVTHLQALQELNVASNFLTDLPGCGAFSSLSVLVIDHN 516

  Fly   854 ------RGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIE 912
                  ..|.|...|...:...  .||:.|.||.::|:       |||..||        |.::|
  Rat   517 SVSHPSSDFFQSCQNIRSITAG--NNPFRCTCELREFV-------KNIGQAS--------REVVE 564

  Fly   913 -------------VEETDI---------CPSVLIYYTSLAVSLLIIALSINVFICFRQP---IMI 952
                         ::.|.:         |.::|:..|..|..||:.|:..::.:.|..|   .|:
  Rat   565 GWPDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLPWYLRML 629

  Fly   953 WFY---EHEICLSLAAR----RELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYL 1009
            |.:   .|.      ||    .||..:.::.||:|::..|...:: |.:..||  :...|:|.:.
  Rat   630 WQWTQTRHR------ARNIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLE--KDDIRVCLHE 686

  Fly  1010 RDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVE 1074
            |:::.|:||.:.|...::.|.:.|.:::.:|::|.|...|...|.|....:....||::|...:.
  Rat   687 RNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIP 751

  Fly  1075 HFDDLDS--ELRAYMVLNTYLD-----RNNPNFWNKLMYSM 1108
            .:....:  :|:..|...|||:     ..:..||..|..|:
  Rat   752 QYSIPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASI 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	4/25 (16%)
		leucine-rich repeat	388..408	CDD:275380	7/20 (35%)
		LRR_8	412..465	CDD:290566	17/54 (31%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	13/39 (33%)
		leucine-rich repeat	433..454	CDD:275378	7/22 (32%)
		leucine-rich repeat	455..478	CDD:275378	8/26 (31%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	5/24 (21%)
		leucine-rich repeat	658..679	CDD:275378	8/56 (14%)
		leucine-rich repeat	680..706	CDD:275378	10/28 (36%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	0/19 (0%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	6/20 (30%)
		leucine-rich repeat	836..859	CDD:275378	9/64 (14%)
		TIR	974..1110	CDD:214587	34/143 (24%)
Tlr1	XP_038947853.1	PRK15370	<51..>146	CDD:185268	28/97 (29%)
		leucine-rich repeat	63..86	CDD:275378	4/22 (18%)
		leucine-rich repeat	87..110	CDD:275378	7/22 (32%)
		leucine-rich repeat	111..125	CDD:275378	6/13 (46%)
		leucine-rich repeat	132..156	CDD:275378	7/28 (25%)
		leucine-rich repeat	157..169	CDD:275378	1/11 (9%)
		PRK15370	<313..>500	CDD:185268	45/248 (18%)
		leucine-rich repeat	368..389	CDD:275380	9/25 (36%)
		leucine-rich repeat	390..415	CDD:275380	6/40 (15%)
		leucine-rich repeat	416..440	CDD:275380	7/50 (14%)
		leucine-rich repeat	441..462	CDD:275380	8/27 (30%)
		leucine-rich repeat	463..485	CDD:275380	4/21 (19%)
		leucine-rich repeat	486..507	CDD:275380	1/20 (5%)
		leucine-rich repeat	508..531	CDD:275380	4/22 (18%)
		LRRCT	540..594	CDD:214507	14/68 (21%)
		TIR	652..795	CDD:214587	34/143 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020