DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr6

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_997487.1	Gene:	Tlr6 / 305353	RGDID:	1303030	Length:	806	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	189/892 - (21%)
Similarity:	331/892 - (37%)	Gaps:	270/892 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 CNCSYNRD----------------------KSQLE--IDCWQKNLTTIPSLPVPKKGSSALVFQS 416
            ||.|.:|:                      ..:||  :|...||||.:|....|  .:.:|....
  Rat    10 CNMSQDREPIVESFHFVCTLALIVGSMTQFSDELESVVDYSNKNLTHVPKDLSP--STKSLSLSQ 72

  Fly   417 NLLAELPDNSLEGYHNLKSLDVSYNQLTSL--SVSQLPESLHYLDIRHNKITTLS--PQV-VEYL 476
            |.:::|..:.:.....|:.|.:|:|::..|  .|..|...|.|||:.||::..:|  |.| :::|
  Rat    73 NSISDLQMSDISFLSELRVLRLSHNRIRRLDFGVFLLNRDLEYLDVSHNQLQNISCCPMVNLKHL 137

  Fly   477 -YSVN------VFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQ--------------TIM 520
             .|.|      |:.::||               ..|...|.:..:||:              .::
  Rat   138 DLSFNDFEVLPVYKEFGN---------------LRKLSFLGLSAAKFRQLDLLPISHLHLSCVLL 187

  Fly   521 EYIELSSKGSFVENFFVQNIDQLYLEANEDEI--------IDAFGPSDKYFNLKLMEALNHAIWL 577
            :.:....|....|:..|.|.:.|:|..:.:.:        ::|.| ..:..|:||.:....::.:
  Rat   188 DLVNYQIKDGETESLQVPNTNVLHLVFHPNSLFSVQVNISVNALG-CLQLSNIKLNDENCQSLII 251

  Fly   578 FSGEFD------EIILHHL--NSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTL 634
            |..|..      .:.|.|:  |..|..|. ..|.|......:|..||:      :..||..:|.:
  Rat   252 FLSELTRGPTLLNLTLQHIETNWKCFVRL-LQFLWPRPVEYLNIYNLT------ITESISRETFI 309

  Fly   635 Y----LDRNEIRKLTNTESLVV--AGHASIHKLHMSQNLLRELP-LHLL-PENITYLDVRNNLLK 691
            |    |...:|..:||...|.|  |.::...::::....|.:.| :|:: ||
  Rat   310 YVETVLKSLKIEHVTNQVFLFVKDALYSVFAEMNIRMLTLSDTPFIHMVCPE------------- 361

  Fly   692 YLDDGVIAFLEYRENI-TKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPED 755
              .....|||.:.:|: |.....|      |      |.|:|.|.:    :|:|
  Rat   362 --FPSTFAFLNFTQNVFTDSIFQG------C------STLKRLETL----ILQR----------- 397

  Fly   756 CICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFY 820
                    |.....:.|....|.:|.:..|........:.|::|..  .|.       .|:....
  Rat   398 --------NGLKNLFKVALMTKTMSSLETLDVSLNSLNSHVYDRTC--AWA-------ESIRVLN 445

  Fly   821 LAHNRLSD--IDQLPDKLEYLDISNNN--------------------------------FSALDD 851
            |:.|.|||  ...||.|::.||:.||.                                ||:|..
  Rat   446 LSSNVLSDSVFRCLPPKVKVLDLHNNRIVSIPKDVTHLQALQELNVASNFLTDLPGCGAFSSLSV 510

  Fly   852 RV----------RGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDT 906
            .|          ..|.|...|...:...  .||:.|.||.::|:       |||..||
  Rat   511 LVIDHNSVSHPSSDFFQSCQNIRSITAG--NNPFRCTCELREFV-------KNIGQAS------- 559

  Fly   907 GRSLIE-------------VEETDI---------CPSVLIYYTSLAVSLLIIALSINVFICFRQP 949
             |.::|             ::.|.:         |.::|:..|..|..||:.|:..::.:.|..|
  Rat   560 -REVVEGWPDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLP 623

  Fly   950 ---IMIWFY---EHEICLSLAAR----RELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKF 1003
               .|:|.:   .|.      ||    .||..:.::.||:|::..|...:: |.:..||  :...
  Rat   624 WYLRMLWQWTQTRHR------ARNIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLE--KDDI 680

  Fly  1004 RLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVV 1068
            |:|.:.|:::.|:||.:.|...::.|.:.|.:::.:|::|.|...|...|.|....:....||::
  Rat   681 RVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILI 745

  Fly  1069 LYPDVEHFDDLDS---ELRAYMVLNTYLD-----RNNPNFWNKLMYS 1107
            |...::. :::.|   :|||.|...|||:     .....||..|..|
  Rat   746 LLEPIQQ-NNIPSRYHKLRALMAQRTYLEWPIEKGKRGLFWANLRAS 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	4/31 (13%)
		leucine-rich repeat	388..408	CDD:275380	8/21 (38%)
		LRR_8	412..465	CDD:290566	16/54 (30%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	14/41 (34%)
		leucine-rich repeat	433..454	CDD:275378	7/22 (32%)
		leucine-rich repeat	455..478	CDD:275378	10/26 (38%)
		leucine-rich repeat	479..490	CDD:275378	4/16 (25%)
		leucine-rich repeat	632..657	CDD:275378	9/30 (30%)
		leucine-rich repeat	658..679	CDD:275378	4/22 (18%)
		leucine-rich repeat	680..706	CDD:275378	3/25 (12%)
		leucine-rich repeat	707..719	CDD:275378	2/12 (17%)
		leucine-rich repeat	771..791	CDD:275380	4/19 (21%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	7/20 (35%)
		leucine-rich repeat	836..859	CDD:275378	9/64 (14%)
		TIR	974..1110	CDD:214587	37/143 (26%)
Tlr6	NP_997487.1	leucine-rich repeat	46..64	CDD:275380	7/19 (37%)
		leucine-rich repeat	65..88	CDD:275378	3/22 (14%)
		LRR_8	87..144	CDD:290566	19/56 (34%)
		leucine-rich repeat	89..112	CDD:275378	7/22 (32%)
		leucine-rich repeat	113..133	CDD:275378	8/19 (42%)
		leucine-rich repeat	134..158	CDD:275378	6/38 (16%)
		leucine-rich repeat	369..385	CDD:275380	5/27 (19%)
		LRR_RI	<380..>500	CDD:238064	29/163 (18%)
		LRR_8	388..451	CDD:290566	15/94 (16%)
		leucine-rich repeat	390..415	CDD:275380	6/47 (13%)
		leucine-rich repeat	416..440	CDD:275380	4/32 (13%)
		leucine-rich repeat	441..462	CDD:275380	7/20 (35%)
		LRR_8	461..516	CDD:290566	9/54 (17%)
		leucine-rich repeat	463..485	CDD:275380	4/21 (19%)
		leucine-rich repeat	486..508	CDD:275380	2/21 (10%)
		leucine-rich repeat	510..531	CDD:275380	3/20 (15%)
		LRRCT	540..594	CDD:214507	14/68 (21%)
		TIR	652..791	CDD:214587	36/141 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920