Protein Alignment Toll-4 and Cd180

DIOPT Version :9

• Sequence 1: NP_523519.2
• Gene: Toll-4 / 34235
• FlyBaseID: FBgn0032095
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001099875.1
• Gene: Cd180 / 294706
• RGDID: 1308170
• Length: 662
• Species: Rattus norvegicus
• Alignment Length: 700
• Identity: 143/700 - (20%)
• Similarity: 257/700 - (36%)
• Gaps: 213/700 - (30%)

  Fly   114 TTEDYQMKLVFLKL---EINWTSPVFHGWNIFKICNETDYELVIISVLGIRSEVDMRISPAVQYL 175
            ||....:.|.||.|   :|.|...     :.|:..:..:..::..:.|...:|..:....|:::|
  Rat    71 TTFSRLVNLTFLDLTRCQIYWIHE-----DTFQSQHRLETLVLTANPLIFMAETALTGPKALKHL 130

  Fly   176 SLL--GIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSV-ITNNYIRKTMNNTEK 237
            ..:  ||..|.    ::|        ||   ..|.:...||..:.::|: :..::      .|||
  Rat   131 FFIQTGISSIE----FIP--------VH---SQKALESLYLGSNHISSIRLPKDF------PTEK 174

  Fly   238 IKIYYHNTFEKTTLTMEKNIFHGKNKMS----------ALIFNGLKIKGLTNNTFENLTSLNTLI 292
            :|:          |..:.|..|..:|..          :|..||..|.|:....|:: |...:|.
  Rat   175 LKV----------LDFQNNAIHHLSKEDVSSLQQATNLSLNLNGNDITGIEPGAFKS-TVFQSLN 228

  Fly   293 FDNV--FLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICE 355
            |...  .|.....|::||:||            :.|.:||...:.|.|..|.::|       :||
  Rat   229 FGGTQSLLVIFKGLQNSTIQS------------LWLGTFEDIDDDEDISSSMFEG-------LCE 274

  Fly   356 ------PYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVF 414
                  ..:.|..|.:..|...|          .....|:|....:||.:||..|.......||.
  Rat   275 MSVERINLQKHHFFNITSNTFYC----------FSGLQELDLTATHLTELPSGIVGLSKLKKLVL 329

  Fly   415 QSNLLAELPDNSLEGYHNLKSLDVSYN----QLTSLSVSQLPESLHYLDIRHNKITT-----LSP 470
            .:|....|...|...:.:|..|.:..|    :|.|..:..| |.|..||:.|:.|.|     |..
  Rat   330 SANKFENLCQISASNFPSLTHLYIKGNTKRLELGSGCLETL-EHLRELDLSHDDIETSDCCNLQL 393

  Fly   471 QVVEYLYSVNV-FNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTI--MEYIELSSKGSFV 532
            :.:.:|.|:|: :|:                       .|.::|..|:..  :|.::|:
  Rat   394 RNLSHLQSLNLSYNE-----------------------PLGLRTEAFKECPQLELLDLA------ 429

  Fly   533 ENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYR 597
                   ..:|:::       ||..|   :.||.|::.||              |.|
  Rat   430 -------FTRLHVK-------DAQSP---FQNLHLLKVLN--------------LSH-------- 455

  Fly   598 CSCCFEWHTGEFLIN----CRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVA----- 653
               |....:.:.|::    .|:|:|. ..|.||....||      |.::.|.:.|.|:::
  Rat   456 ---CLLGSSNQHLLDGLPALRHLNLQ-GNRFPNGNIQKT------NPLQALGSLEILILSFCDLS 510

  Fly   654 --GHAS------IHKLHMSQNLLRELPLHLLPE-NITYLDVRNNLLKYLDDGVIAFLEYRENITK 709
              .|.:      ::.:.:|.|.|....:..|.. ...||::.:|.:..:...::..|..:..
  Rat   511 SIDHQAFINLKIMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIPPSLLPVLSQQRT--- 572

  Fly   710 IELSGNPWECNCKAKAFLSF----LRRHEPMEYET------VLRRVEITD 749
            |.|..||.:|.|....||.:    :::.|.:| :|      :||.|:::|
  Rat   573 INLRQNPLDCTCSNIYFLEWYKENMQKLEDIE-DTFCANPPLLRGVKVSD 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	6/32 (19%)
		leucine-rich repeat	288..308	CDD:275380	4/21 (19%)
		leucine-rich repeat	309..334	CDD:275380	5/24 (21%)
		leucine-rich repeat	335..386	CDD:275380	10/56 (18%)
		leucine-rich repeat	388..408	CDD:275380	7/19 (37%)
		LRR_8	412..465	CDD:290566	16/56 (29%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	14/46 (30%)
		leucine-rich repeat	433..454	CDD:275378	6/24 (25%)
		leucine-rich repeat	455..478	CDD:275378	8/27 (30%)
		leucine-rich repeat	479..490	CDD:275378	2/11 (18%)
		leucine-rich repeat	632..657	CDD:275378	6/31 (19%)
		leucine-rich repeat	658..679	CDD:275378	4/21 (19%)
		leucine-rich repeat	680..706	CDD:275378	4/25 (16%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
Cd180	NP_001099875.1	leucine-rich repeat	55..78	CDD:275380	2/6 (33%)
		leucine-rich repeat	79..102	CDD:275380	7/27 (26%)
		leucine-rich repeat	103..126	CDD:275380	2/22 (9%)
		leucine-rich repeat	127..150	CDD:275380	7/37 (19%)
		leucine-rich repeat	151..174	CDD:275380	4/28 (14%)
		leucine-rich repeat	175..195	CDD:275380	5/29 (17%)
		leucine-rich repeat	196..223	CDD:275380	6/27 (22%)
		leucine-rich repeat	224..244	CDD:275380	4/19 (21%)
		leucine-rich repeat	277..300	CDD:275380	4/32 (13%)
		LRR_RI	301..480	CDD:238064	51/251 (20%)
		leucine-rich repeat	301..323	CDD:275380	7/21 (33%)
		LRR_8	322..383	CDD:290566	16/61 (26%)
		leucine-rich repeat	324..347	CDD:275380	5/22 (23%)
		leucine-rich repeat	348..372	CDD:275380	6/24 (25%)
		LRR_8	372..433	CDD:290566	16/96 (17%)
		leucine-rich repeat	373..398	CDD:275380	7/24 (29%)
		leucine-rich repeat	399..422	CDD:275380	7/45 (16%)
		LRR_8	421..482	CDD:290566	18/109 (17%)
		leucine-rich repeat	423..447	CDD:275380	8/46 (17%)
		leucine-rich repeat	448..471	CDD:275380	6/47 (13%)
		leucine-rich repeat	472..498	CDD:275380	10/32 (31%)
		LRR_8	498..556	CDD:290566	10/57 (18%)
		leucine-rich repeat	499..522	CDD:275380	3/22 (14%)
		leucine-rich repeat	523..546	CDD:275380	4/22 (18%)
		TPKR_C2	578..627	CDD:301599	12/44 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910