DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr5

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001139300.1	Gene:	Tlr5 / 289337	RGDID:	631351	Length:	871	Species:	Rattus norvegicus

Alignment Length:	879	Identity:	198/879 - (22%)
Similarity:	333/879 - (37%)	Gaps:	220/879 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 LGINEVACP-LKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLE 428
            :|:..:|.| |:.:..::..:..|...|   |||.||.:   ...:..|:...|.::.:...|..
  Rat    21 IGVVFMASPVLEMSPCFSDGRIALFRGC---NLTQIPWV---LNTTERLLLSFNYISTVVTTSFP 79

  Fly   429 GYHNLKSLDVSYNQLTSLSVSQ-----LPESLHYLDIRHNKITTLSP---QVVEYLYSVNVFNQY 485
            ....|..|::. .|...|::.|     || :|..||:..::|..|:|   |.:.:|:.:.:|: .
  Rat    80 LLEQLLLLELG-TQYARLTIGQEAFRNLP-NLRILDLGQSQIEVLNPDAFQGLPHLFELRLFD-C 141

  Fly   486 GNKWSIYCDEYHLQEFFWYKAKLLRIKT-----------SKFQTIMEYIELSSKGSFVENFFVQN 539
            |...::..|.|     |.....|.|:..           |.||      ||||....  ||....
  Rat   142 GLSNAVLRDAY-----FRNLNSLARLDLSANEIHSLHLHSSFQ------ELSSLSDI--NFSFNR 193

  Fly   540 IDQLYLEANEDEIIDAFGPSDKYFNLKL----------MEALNHAI--------------WLFS- 579
            |..|.    |||:....|.:..:|.||.          .||..:.:              |..:
  Rat   194 IFTLC----EDELQPLQGRTLSFFGLKSTSLFSRVFVDWEACRNPLRGIRLETLDLSENGWTAAI 254

  Fly   580 -GEFDE----------IILHHL--------NSPCPYRCSCCFEWHTGEFLINCRNLSLD------ 619
             |.|..          |:.:|:        |...|       :..|...|.....|.||
  Rat   255 LGNFSHTIQGSHISSLILTYHIMGSGFGFQNIKDP-------DQSTFASLARSSVLQLDLSHGYI 312

  Fly   620 --IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLREL---PLHLLPEN 679
              :.|||..::.....|.|..|:|.|:::   ....|..|:..|::|.|||.||   ..:.|| :
  Rat   313 FSLNPRLFETLKDLKKLNLAFNKINKISD---YAFHGLDSLQILNLSYNLLGELYNSNFYGLP-S 373

  Fly   680 ITYLDVRNNLLKYLDDGV------IAFLEYRENITK----------------------------- 709
            |.|||::.|.:..:.|..      :..|:.|:|..|
  Rat   374 IAYLDLQRNHIGIIQDRTFRLLKKLQTLDLRDNALKTIGFIPSVQMVLLGSNKLTHLPHVRFTAN 438

  Fly   710 -IELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITD----DKCPEDCICCVDTSNSDSLA 769
             ||||.|..|    ..:.|.||.|...::: .:|.:..::.    |..|...:.......::::.
  Rat   439 FIELSENGLE----NLSDLYFLLRIPGLQF-LILNQNRLSSCSNVDYAPSQNLSLEQLFLAENML 498

  Fly   770 YVVDCSG------KELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSD 828
            .:...:|      |.||.:          ..|....|.|...|..:..|..::....|:.|||:.
  Rat   499 QLAWETGLCWDIFKGLSRL----------QILYLNNNYLNFLPPGIFNGLVALRMLSLSANRLTM 553

  Fly   829 ID--QLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQ 891
            :.  .||..||.||||.|...:.|        ..:.||...|.:..|.:.|.||...|:|::.:.
  Rat   554 LSPGSLPANLEILDISRNQLFSPD--------PGLFSSLRALDITHNEFICDCELSTFIVWLNQT 610

  Fly   892 AKNIANASA-IQCID----TGRSLIEVEETDICP----------SVLIYYTSLAVSLLIIALSIN 941
            ...:..:.| :.|:.    .|.||..:...| |.          |:.|..|......|:|.|.:.
  Rat   611 NVTLFGSPADVYCMYPNSLLGSSLYNISTKD-CDEEEAVRSLNFSLFILCTVTLTLFLVITLIVT 674

  Fly   942 -----VFICFR--QPIMIWFYEHEICLSLAARRELDEDKKYDAFLSFTHKD----EDLIEEFVDR 995
                 .|:||:  |.:|   ::.:.      |.......:|||:..|:.||    ::.:.:.:|.
  Rat   675 KFRGICFLCFKTIQKLM---FKGKF------RNPEPSAYRYDAYFCFSSKDFEWAQNALLKHLDA 730

  Fly   996 LENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRD 1060
            ..:.:::.||||..||::.||:....|..:|.|||:.:.|::::|||..|....||.|......|
  Rat   731 QYSSQNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYAQSRCLSD 795

  Fly  1061 RCKRLIVVLYPDVEHFDDLDSE-LRAYMVLNTYL 1093
            ..:.||||:...:..:..:..| :|.::....||
  Rat   796 LKRVLIVVVVGSLPQYQLMRHETIRGFLQKQQYL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	4/21 (19%)
		leucine-rich repeat	388..408	CDD:275380	6/19 (32%)
		LRR_8	412..465	CDD:290566	13/57 (23%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	12/42 (29%)
		leucine-rich repeat	433..454	CDD:275378	7/25 (28%)
		leucine-rich repeat	455..478	CDD:275378	8/25 (32%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	6/24 (25%)
		leucine-rich repeat	658..679	CDD:275378	9/23 (39%)
		leucine-rich repeat	680..706	CDD:275378	8/31 (26%)
		leucine-rich repeat	707..719	CDD:275378	6/41 (15%)
		leucine-rich repeat	771..791	CDD:275380	4/25 (16%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	6/20 (30%)
		leucine-rich repeat	836..859	CDD:275378	8/22 (36%)
		TIR	974..1110	CDD:214587	37/125 (30%)
Tlr5	NP_001139300.1	LRR_8	<96..143	CDD:404697	13/48 (27%)
		PLN00113	<108..>384	CDD:215061	71/304 (23%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		leucine-rich repeat	133..158	CDD:275380	6/30 (20%)
		leucine-rich repeat	159..183	CDD:275380	7/29 (24%)
		leucine-rich repeat	184..217	CDD:275380	10/38 (26%)
		leucine-rich repeat	240..301	CDD:275380	9/67 (13%)
		leucine-rich repeat	302..325	CDD:275380	6/22 (27%)
		LRR	314..>578	CDD:227223	65/290 (22%)
		LRR_8	326..384	CDD:404697	21/61 (34%)
		leucine-rich repeat	326..349	CDD:275380	6/25 (24%)
		leucine-rich repeat	350..373	CDD:275380	9/23 (39%)
		leucine-rich repeat	374..397	CDD:275380	6/22 (27%)
		leucine-rich repeat	398..432	CDD:275380	4/33 (12%)
		leucine-rich repeat	433..461	CDD:275380	10/31 (32%)
		leucine-rich repeat	462..487	CDD:275380	3/25 (12%)
		leucine-rich repeat	488..516	CDD:275380	3/27 (11%)
		leucine-rich repeat	517..540	CDD:275380	5/32 (16%)
		leucine-rich repeat	541..559	CDD:275380	4/17 (24%)
		leucine-rich repeat	563..586	CDD:275380	10/30 (33%)
		PCC	567..>645	CDD:188093	21/86 (24%)
		TIR	706..856	CDD:396246	37/124 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920