DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr13

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_991389.1	Gene:	Tlr13 / 279572	MGIID:	3045213	Length:	991	Species:	Mus musculus

Alignment Length:	1074	Identity:	217/1074 - (20%)
Similarity:	376/1074 - (35%)	Gaps:	322/1074 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LVFLKLEINWTSPVFHGWN-IFKICNETDYELVIISVLGIRSEVDMRISPAVQYLSLLGIREISG 185
            ||.|:||          || |:||.......|..:::|.:.......::.:.:.||
Mouse   129 LVDLRLE----------WNSIWKIDEGAFRGLENLTLLNLVENKIQSVNNSFEGLS--------- 174

  Fly   186 YDIYLPSVLITEMDVHHANG---PKMVTFKYL---------YDSTVNSV----------ITNNYI 228
               .|.::|::...:.|.:.   ..::..|||         :...:.:|          :|||.|
Mouse   175 ---SLKTLLLSHNQITHIHKDAFTPLIKLKYLSLSRNNISDFSGILEAVQHLPCLERLDLTNNSI 236

  Fly   229 RKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLN-TLI 292
            ....::...:....|.:||             .||:..|.|:.|.:..|||.:    .|.| ..:
Mouse   237 MYLDHSPRSLVSLTHLSFE-------------GNKLRELNFSALSLPNLTNLS----ASRNGNKV 284

  Fly   293 FDNVFLKDLSFLRSSTLQSSLTYCIMKVDNM----------VDLKSFE-KFTNLEIIEVSQYKGF 346
            ..||:||.|..|:|..|..:    ::|::|:          :||.::| :..:|::..|....|
Mouse   285 IQNVYLKTLPQLKSLNLSGT----VIKLENLSAKHLQNLRAMDLSNWELRHGHLDMKTVCHLLG- 344

  Fly   347 KNFTAFICEPYKSHCKFTLGINEVACPLKC------NCSYNRDKSQLEIDCWQKNLTTIPSLPVP 405
             |........::.:.....||.::|   ||      :...|.|...|.    ......:|||...
Mouse   345 -NLPKLETLVFQKNVTNAEGIKQLA---KCTRLLFLDLGQNSDLIYLN----DSEFNALPSLQKL 401

  Fly   406 KKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTS---LSVSQLPESLHYLDIRHNKITT 467
            ......|.|.:|       .:.....||.|||:|:|:..|   .:.|.| :.|.:|.:..|.||.
Mouse   402 NLNKCQLSFINN-------RTWSSLQNLTSLDLSHNKFKSFPDFAFSPL-KHLEFLSLSRNPITE 458

  Fly   468 LSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFV 532
            |:......|:::...| ....|.:..|.|...:|
Mouse   459 LNNLAFSGLFALKELN-LAACWIVTIDRYSFTQF------------------------------- 491

  Fly   533 ENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYR 597
                 .|::.|.|..|.                  :..|||..:....:...:||.|       .
Mouse   492 -----PNLEVLDLGDNN------------------IRTLNHGTFRPLKKLQSLILSH-------N 526

  Fly   598 CSCCFEWHTGEFLINCRNLSLDIYPRLP--------------------NSIPYKTTLYLDRNEIR 642
            |....|.::...|.|.|:|.| :|..|.                    |.|.|:||..|......
Mouse   527 CLKILEPNSFSGLTNLRSLDL-MYNSLSYFHEHLFSGLEKLLILKLGFNKITYETTRTLQYPPFI 590

  Fly   643 KLTNTESLVVAG--HASIHKLHMSQNLLRELPLHLLPENITY-LDVRNNLLKYLDDGVIAFLEYR 704
            ||.:.:.|.:.|  |.                :.::|.|... |.....||  |......||::.
Mouse   591 KLKSLKQLNLEGQRHG----------------IQVVPSNFFQGLGSLQELL--LGKNPSVFLDHH 637

  Fly   705 E-----NITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSN 764
            :     |:||:::||                                               |.:
Mouse   638 QFDPLINLTKLDISG-----------------------------------------------TKD 655

  Fly   765 SDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDI 829
            .|...|:.....:.|..:          ..|..|.|:|:.....:.....|:..|.|..|.|..|
Mouse   656 GDRSLYLNASLFQNLKRL----------KILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVI 710

  Fly   830 DQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCED---KDFLVFVKEQ 891
            :|  ..|:.|                       .|.:...::||...|.|::   |::.:..:|
Mouse   711 NQ--SHLKNL-----------------------KSLMFFDVYGNKLQCTCDNLWFKNWSMNTEE- 749

  Fly   892 AKNIANASAIQCIDTGRSLIEVEETD-ICPSVL--IYYTSLAVSLLIIALSINVFICFRQPIM-- 951
             .:|....:..|...|...:.::..| :|...|  :|:    :....:.||..||..|...::
Mouse   750 -VHIPFLRSYPCQQPGSQSLLIDFDDAMCNFDLGKVYF----LCSFSMVLSTMVFSWFSTKMIAS 809

  Fly   952 IWFYEHEICLSLAARRELDEDKK--YDAFLSFTHKDEDLI-EEFVDRLENG-RHKFRLCFYLRDW 1012
            :| |...||.:....:....:||  ||||:||:..||..: :|.|..||.| :..|:||.:.||:
Mouse   810 LW-YGLYICRAWYLTKWHKTEKKFLYDAFVSFSATDEAWVYKELVPALEQGSQTTFKLCLHQRDF 873

  Fly  1013 LVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFD 1077
            ..|..|.:.|..::..||:.:.:::.::|.|.|.|||.:||......:....:|::...::.::
Mouse   874 EPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWCRLEVQLASMKMFYEHKDVIILIFLEEIPNY- 937

  Fly  1078 DLDSELRAYMVLN-----TYLD--RNNPNFWNKL 1104
            .|.|..|...::|     |:.|  ...|.||.::
Mouse   938 KLSSYHRLRKLINKQTFITWPDSVHQQPLFWARI 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..308	CDD:275380	8/20 (40%)
		leucine-rich repeat	309..334	CDD:275380	6/35 (17%)
		leucine-rich repeat	335..386	CDD:275380	11/56 (20%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		LRR_8	412..465	CDD:290566	16/55 (29%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	16/40 (40%)
		leucine-rich repeat	433..454	CDD:275378	9/23 (39%)
		leucine-rich repeat	455..478	CDD:275378	7/22 (32%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	8/26 (31%)
		leucine-rich repeat	658..679	CDD:275378	1/20 (5%)
		leucine-rich repeat	680..706	CDD:275378	6/31 (19%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380	1/19 (5%)
		leucine-rich repeat	793..815	CDD:275378	4/21 (19%)
		leucine-rich repeat	816..835	CDD:275378	6/18 (33%)
		leucine-rich repeat	836..859	CDD:275378	2/22 (9%)
		TIR	974..1110	CDD:214587	42/142 (30%)
Tlr13	NP_991389.1	LRR 1	104..125
		leucine-rich repeat	105..128	CDD:275380
		LRR_8	106..163	CDD:290566	12/43 (28%)
		LRR 2	128..149		10/29 (34%)
		leucine-rich repeat	129..152	CDD:275380	11/32 (34%)
		LRR 3	152..174		1/21 (5%)
		leucine-rich repeat	153..175	CDD:275380	3/33 (9%)
		LRR 4	175..196		3/20 (15%)
		leucine-rich repeat	176..199	CDD:275380	3/22 (14%)
		LRR_8	183..236	CDD:290566	8/52 (15%)
		LRR_RI	<192..405	CDD:238064	49/242 (20%)
		LRR 5	199..220		3/20 (15%)
		leucine-rich repeat	200..225	CDD:275380	4/24 (17%)
		LRR 6	225..246		4/20 (20%)
		leucine-rich repeat	226..248	CDD:275380	4/21 (19%)
		LRR 7	248..268		7/32 (22%)
		leucine-rich repeat	249..271	CDD:275380	8/34 (24%)
		LRR 8	271..292		8/24 (33%)
		leucine-rich repeat	272..295	CDD:275380	10/26 (38%)
		LRR 9	295..315		5/23 (22%)
		leucine-rich repeat	296..319	CDD:275380	5/26 (19%)
		LRR 10	318..338		4/19 (21%)
		LRR 11	348..368		2/19 (11%)
		LRR 12	372..394		3/25 (12%)
		leucine-rich repeat	373..397	CDD:275380	3/27 (11%)
		LRR_8	396..456	CDD:290566	19/67 (28%)
		LRR 13	397..418		5/27 (19%)
		leucine-rich repeat	398..421	CDD:275380	4/29 (14%)
		LRR_4	420..463	CDD:289563	16/43 (37%)
		LRR 14	421..442		8/20 (40%)
		leucine-rich repeat	422..445	CDD:275380	9/23 (39%)
		LRR 15	445..466		6/20 (30%)
		leucine-rich repeat	446..469	CDD:275380	7/22 (32%)
		LRR 16	469..490		4/21 (19%)
		leucine-rich repeat	470..493	CDD:275380	5/59 (8%)
		LRR_8	492..552	CDD:290566	18/85 (21%)
		LRR 17	493..514		7/38 (18%)
		leucine-rich repeat	494..517	CDD:275380	6/40 (15%)
		LRR 18	517..538		5/27 (19%)
		leucine-rich repeat	518..541	CDD:275380	6/29 (21%)
		LRR_8	540..602	CDD:290566	15/62 (24%)
		LRR 19	541..562		6/21 (29%)
		leucine-rich repeat	542..565	CDD:275380	5/23 (22%)
		LRR 20	565..585		5/19 (26%)
		leucine-rich repeat	566..585	CDD:275380	5/18 (28%)
		LRR 21	594..617		5/38 (13%)
		LRR 22	620..641		5/22 (23%)
		LRR 23	644..665		8/67 (12%)
		LRR_8	671..731	CDD:290566	16/94 (17%)
		LRR 24	672..693		4/30 (13%)
		leucine-rich repeat	673..696	CDD:275380	4/32 (13%)
		LRR 25	696..716		7/21 (33%)
		leucine-rich repeat	697..718	CDD:275380	7/22 (32%)
		TIR	834..976	CDD:214587	41/139 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920