DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and IL1RAPL2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_059112.1	Gene:	IL1RAPL2 / 26280	HGNCID:	5997	Length:	686	Species:	Homo sapiens

Alignment Length:	289	Identity:	62/289 - (21%)
Similarity:	129/289 - (44%)	Gaps:	70/289 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   857 LQKRMNSSQLQLSLFGNP--------WTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGR--SLI 911
            |::.:...:::|:|..:.        :||..|:::                       ||  :.:
Human   303 LKEHLGEKEVELALIFDSVVEADLANYTCHVENRN-----------------------GRKHASV 344

  Fly   912 EVEETDICPSVLIYYTSLAVSL----LIIALSINVFICFRQPIMIWFYEHEICLSLAARRELDED 972
            .:.:.|     |||...||..|    |::.|.:.::.|:...:|:::.:|     ..|....|::
Human   345 LLRKKD-----LIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQH-----FGADETNDDN 399

  Fly   973 KKYDAFLSFTHKDEDLI-------EEFV-----DRLENGRHKFRLCFYLRDWLVGESIPDCINQS 1025
            |:|||:||:|..|:|.:       |:|.     |.||. .:.::|....||.:...:..:.:.:.
Human   400 KEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEK-HYGYKLFIPERDLIPSGTYMEDLTRY 463

  Fly  1026 VKGSRRIIILMTKNF-LKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVE---HFDDLDSELRAY 1086
            |:.|||:||::|.:: |:..|...|....||........::|::...:::   :..:::|..|:.
Human   464 VEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSI 528

  Fly  1087 MVLN------TYLDRNNPNFWNKLMYSMP 1109
            .:|:      :...:.|..||..|:|.||
Human   529 KLLSLIKWKGSKSSKLNSKFWKHLVYEMP 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378	1/1 (100%)
		TIR	974..1110	CDD:214587	39/158 (25%)
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142
		Ig2_IL1R_like	146..237	CDD:319309
		IG_like	250..347	CDD:214653	8/66 (12%)
		TIR	402..563	CDD:307630	39/157 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910