DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and Il1rap

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_038943965.1	Gene:	Il1rap / 25466	RGDID:	2893	Length:	697	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	111/635 - (17%)
Similarity:	217/635 - (34%)	Gaps:	209/635 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 QEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYF 563
            ::..|::..||. .|..:..::......||.:|                 ..|::.    .|..|
  Rat   108 KDVLWFRPTLLN-DTGNYTCMLRNTTYCSKVAF-----------------PLEVVQ----KDSCF 150

  Fly   564 NLKLMEALNHAIWLFSGEFDEIILHHLNSP-----CPYRCSCCFEWHTG-EFLINCRN-----LS 617
            | ..|....|.:::..|      :|::..|     .|........|:.| ..::|..|     ::
  Rat   151 N-SPMRLPVHRLYIEQG------IHNITCPNVDGYFPSSVKPSVTWYKGCTEIVNFHNVQPKGMN 208

  Fly   618 LDIY-PRLPNSIPYKTTL-YLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENI 680
            |..: |.:.|:..|...: ||:...:..||.|.::.|.|...           ..:|.|:...|
  Rat   209 LSFFIPLVSNNGNYTCVVTYLENGRLFHLTRTMTVKVVGSPK-----------DAVPPHIYSPN- 261

  Fly   681 TYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRV 745
                          |.|:...|..|.:.            ...|.:.||:.......:.|:
  Rat   262 --------------DRVVYEKEPGEELV------------IPCKVYFSFIMDSHNEIWWTI---- 296

  Fly   746 EITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQT-TLVFERNSLKKWPSSL 809
               |.|.|:|  ..||.:.::|::|                :.|..:| |.:.   |:||    :
  Rat   297 ---DGKKPDD--VPVDITINESVSY----------------SSTEDETRTQIL---SIKK----V 333

  Fly   810 LPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNP 874
            .|  ..:.|.|:.|.|.::.:
  Rat   334 TP--EDLKRNYVCHARNAEGE-------------------------------------------- 352

  Fly   875 WTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALS 939
                          .|||     |...|.:...|..:|:    .|        ....::.::.:.
  Rat   353 --------------AEQA-----AKVKQKVIPPRYTVEL----AC--------GFGATVFLVVVL 386

  Fly   940 INVFICFRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSFTHKDEDLIEEFV-----DRLENG 999
            |.|:..:...:::::..|     ......:.:.|:||.::|:....|:  ||||     ..|||
  Rat   387 IVVYHVYWLEMVLFYRAH-----FGTDETILDGKEYDIYVSYARNAEE--EEFVLLTLRGVLEN- 443

  Fly  1000 RHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFL-KSTWGRLEFRLALHATSRDRCK 1063
            ...::||.:.||.|.|.:..:.:...::.|||:|::::.::: :.:...|||:|.:...:....|
  Rat   444 EFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIATK 508

  Fly  1064 RLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRNNPN----FWNKLMYSMP 1109
             ||||.|..:|.......:|:..:...::....:.:    ||..|..::|
  Rat   509 -LIVVEYRPLEQPHPGIMQLKESVSFVSWKGEKSKHSGSKFWKALRLALP 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	7/25 (28%)
		leucine-rich repeat	658..679	CDD:275378	2/20 (10%)
		leucine-rich repeat	680..706	CDD:275378	3/25 (12%)
		leucine-rich repeat	707..719	CDD:275378	0/11 (0%)
		leucine-rich repeat	771..791	CDD:275380	1/19 (5%)
		leucine-rich repeat	793..815	CDD:275378	6/22 (27%)
		leucine-rich repeat	816..835	CDD:275378	4/18 (22%)
		leucine-rich repeat	836..859	CDD:275378	0/22 (0%)
		TIR	974..1110	CDD:214587	37/146 (25%)
Il1rap	XP_038943965.1	Ig1_IL1R_like	37..144	CDD:409584	8/53 (15%)
		Ig strand B	55..59	CDD:409584
		Ig strand C	79..83	CDD:409584
		Ig strand E	109..113	CDD:409584	0/3 (0%)
		Ig strand F	123..128	CDD:409584	0/4 (0%)
		Ig strand G	136..139	CDD:409584	1/2 (50%)
		Ig	155..247	CDD:416386	19/97 (20%)
		Ig strand A	157..162	CDD:409353	1/4 (25%)
		Ig strand A	157..162	CDD:409353	1/4 (25%)
		Ig strand B	168..172	CDD:409353	1/3 (33%)
		Ig strand B	168..172	CDD:409353	1/3 (33%)
		Ig strand C	186..191	CDD:409353	1/4 (25%)
		Ig strand C	186..191	CDD:409353	1/4 (25%)
		Ig strand C'	194..196	CDD:409353	0/1 (0%)
		Ig strand C'	194..196	CDD:409353	0/1 (0%)
		Ig strand D	201..205	CDD:409353	1/3 (33%)
		Ig strand D	201..205	CDD:409353	1/3 (33%)
		Ig strand E	207..212	CDD:409353	1/4 (25%)
		Ig strand E	207..212	CDD:409353	1/4 (25%)
		Ig strand F	221..230	CDD:409353	2/8 (25%)
		Ig strand F	221..230	CDD:409353	2/8 (25%)
		Ig strand G	233..246	CDD:409353	3/12 (25%)
		Ig strand G	233..246	CDD:409353	3/12 (25%)
		Ig3_IL1RAP	255..361	CDD:409525	33/229 (14%)
		Ig strand B	274..278	CDD:409525	0/15 (0%)
		Ig strand C	291..295	CDD:409525	0/3 (0%)
		Ig strand E	326..330	CDD:409525	0/6 (0%)
		Ig strand F	341..346	CDD:409525	1/4 (25%)
		Ig strand G	353..356	CDD:409525	1/2 (50%)
		TIR	416..559	CDD:214587	37/146 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910