DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and Sigirr

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_006536238.2	Gene:	Sigirr / 24058	MGIID:	1344402	Length:	414	Species:	Mus musculus

Alignment Length:	230	Identity:	52/230 - (22%)
Similarity:	98/230 - (42%)	Gaps:	49/230 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   918 ICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYE--HEICLSLAARRELDEDKKYDAFLS 980
            :..|:|:....|.|:||.:...:|        :::|:.:  .|:        |:::.|.|||::|
Mouse   126 VLASLLVLVVLLLVALLYVKCRLN--------MLLWYQDTYGEV--------EMNDGKLYDAYVS 174

  Fly   981 FTHKDEDLIEEFVD-----RLENGRHKFRLCFYLRDWLV-GESIPDCINQSVKGSRRIIILMTKN 1039
            ::...||  .:||:     :||. |..::|....||.|. .|...|.: .::...||:|::::..
Mouse   175 YSDCPED--RKFVNFILKPQLER-RRGYKLFLEDRDLLPRAEPSADLL-VNLSRCRRLIVVLSDA 235

  Fly  1040 FLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSE--------LRAYMVLNTYL--- 1093
            ||...|....||..|       |:.|.:...|....|:....|        ||.:..|.|.:
Mouse   236 FLSRPWCSQSFREGL-------CRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLVLWK 293

  Fly  1094 ---DRNNPNFWNKLMYSMPHASHLKRSRSDAETKV 1125
               ...:.:||.:|..::|.....:....|.:|::
Mouse   294 PGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587	38/155 (25%)
Sigirr	XP_006536238.2	Ig_3	14..106	CDD:372822
Sigirr	XP_006536238.2	TIR	169..331	CDD:366714	41/171 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910