DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr11

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_991388.2	Gene:	Tlr11 / 239081	MGIID:	3045226	Length:	931	Species:	Mus musculus

Alignment Length:	1037	Identity:	233/1037 - (22%)
Similarity:	382/1037 - (36%)	Gaps:	304/1037 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 YLYDSTVNSVITNNYIRKTMNNTE-------------KIKIYYHN----TFEKTTLTMEKNIFHG 260
            :|..|..|....|..:::...|||             |..|.:|:    ..:..|.::....|.|
Mouse    66 HLLASCSNVKNLNQTLKRVPRNTEVLCLQGMVPTLPAKAFIRFHSLQLLRLQLRTTSVTSRTFQG 130

  Fly   261 KNKMSALIFNG-----LKIKGLTNNTFENLTSLNTLIF--------DNVFLKDLSFLRSSTLQSS 312
            .:::..|.|:.     |.: .|:.|.||:|.||::|.|        .:::|.  :.||..||::|
Mouse   131 LDQLQYLFFDHHAPCCLSL-FLSPNCFESLRSLSSLSFQGYCLTYSQSIYLP--TSLRHLTLRNS 192

  Fly   313 LTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCN 377
               |:.|..::..|     |.:| ::..|.....|....|:         .||.:
Mouse   193 ---CLTKFQDLQRL-----FPDL-LLSTSSTPNIKPGAPFL---------ETLDL---------- 229

  Fly   378 CSYNRDKSQLEI-DCWQKNL-------TTIPSLPVPKKGSSALVFQSNL---LAELPDNSLEGYH 431
             |||....|..: |.:...|       |.:.:|.:...|...|.|.|.:   :.::| .||.||.
Mouse   230 -SYNLQLKQAGVRDLYGLTLHSLILDGTPLKALDLTDSGLLHLHFLSLVGTGIEKVP-ASLTGYS 292

  Fly   432 NLKSLDVSYNQLTS-LSVSQLP--ESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYC 493
            .|::||:..||:.: |...::|  ::|.:|.:..|.:.||..:.:..|..:...|...||
Mouse   293 ELRALDLGKNQIQNILENGEIPGYKALEFLSLHDNHLQTLPTRFLHTLPQLQKLNLSMNK----- 352

  Fly   494 DEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELS-------------------------SKGSFVE 533
                       ...:|.:....|.|.::.::||                         :..|.:.
Mouse   353 -----------LGPILELPEGLFSTNLKVLDLSYNQLCDVPHGALSLLSQLQELWLSGNNISSLS 406

  Fly   534 NFFVQNIDQLY---LEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILH-HLNSPC 594
            |..:|.:.||.   |..|:.:::.....|    :|..:..||     ..|.:.|.||. .|..|.
Mouse   407 NESLQGLRQLRTLDLSWNQIKVLKPGWLS----HLPALTTLN-----LLGTYLEYILGIQLQGPK 462

  Fly   595 PYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIH 659
            ..|     ....|.:.|      |||||      |:..||.             ||.:...:.|.
Mouse   463 MLR-----HLQLGSYPI------LDIYP------PWPPTLL-------------SLEIQAESCIQ 497

  Fly   660 -KLHMSQ------NLLRELPLHLL-PENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNP 716
             .:|..|      ||..|..:.|| |:|||                |.|    .::.::.|.|
Mouse   498 FMIHSGQPFLFLENLTLETSILLLKPDNIT----------------IHF----PSLRRLTLRG-- 540

  Fly   717 WECNCKAKAFL---SFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKE 778
                   .:|:   |.|:|..|.:...:           ....|.|   .||    |.||.   .
Mouse   541 -------YSFIFSTSQLQRFFPQQLPLL-----------EHFFIWC---ENS----YAVDL---Y 577

  Fly   779 LSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISN 843
            |..:|:|.....|.....:|.:::|.  ..||.....:....|:|            |...::|.
Mouse   578 LFGMPRLRVLELGYLNFFYESSTMKL--EMLLKEVPQLQVLALSH------------LNLRNLSV 628

  Fly   844 NNFSALDD-RVRGFLQKR---MNSS------QL-QLSLFGN-PWTCRCEDK----------DFLV 886
            ::|.:|.| ::..|..:|   |||:      |: |...|.: .:||:||..          :..|
Mouse   629 SSFKSLQDLKLLLFNSERALEMNSNLQEFIPQMPQYVYFSDVTFTCQCEASWLESWATRAPNTFV 693

  Fly   887 FVKEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYY---TSLAVSLLIIALSINVFICFRQ 948
            :..|::..|||||     |..::|:.......||....::   ||..:.||:|.|.:  ..|
Mouse   694 YGLEKSICIANAS-----DYSKTLLFSFLATNCPHGTEFWGFLTSFILLLLLIILPL--ISC--- 748

  Fly   949 PIMIWFYE-----HEICLSLAARRELDEDKKYDAFLSFTHKDED-LIEEFVDRLENGRHK---FR 1004
            |...|.:.     |.....|...| |.....||.|:|:..:|:. ::||.|..||....:   .|
Mouse   749 PKWSWLHHLWTLFHTCWWKLCGHR-LRGQFNYDVFISYCEEDQAWVLEELVPVLEKAPPEGEGLR 812

  Fly  1005 LCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLA-LHATSRDRCKRLIVV 1068
            ||...||:.:|....:.:..|:..||..:.::|...|.|.|..||.||| .|..:|.....|:::
Mouse   813 LCLPARDFGIGNDRMESMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGTTHLLLL 877

  Fly  1069 LYPDVEHFDDLDSE-LRAYMVLNTYLDRNNPNF--------WNKLMYSMPHASHLKRSRSDA 1121
            .      .:.||.: |.:|..|:.:|.:.: .|        ||..      ...|||..|.|
Mouse   878 F------LEPLDRQRLHSYHRLSRWLQKED-YFDLSQGKVEWNSF------CEQLKRRLSKA 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/27 (30%)
		leucine-rich repeat	288..308	CDD:275380	6/27 (22%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		leucine-rich repeat	335..386	CDD:275380	9/50 (18%)
		leucine-rich repeat	388..408	CDD:275380	4/27 (15%)
		LRR_8	412..465	CDD:290566	18/58 (31%)
		leucine-rich repeat	412..432	CDD:275378	8/22 (36%)
		LRR_4	432..470	CDD:289563	12/40 (30%)
		leucine-rich repeat	433..454	CDD:275378	7/23 (30%)
		leucine-rich repeat	455..478	CDD:275378	6/22 (27%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	4/24 (17%)
		leucine-rich repeat	658..679	CDD:275378	9/28 (32%)
		leucine-rich repeat	680..706	CDD:275378	4/25 (16%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	5/19 (26%)
		leucine-rich repeat	793..815	CDD:275378	4/21 (19%)
		leucine-rich repeat	816..835	CDD:275378	2/18 (11%)
		leucine-rich repeat	836..859	CDD:275378	6/23 (26%)
		TIR	974..1110	CDD:214587	40/149 (27%)
Tlr11	NP_991388.2	LRR_RI	<184..427	CDD:238064	60/288 (21%)
		leucine-rich repeat	224..246	CDD:275380	7/41 (17%)
		leucine-rich repeat	248..270	CDD:275380	4/21 (19%)
		leucine-rich repeat	271..293	CDD:275380	8/22 (36%)
		leucine-rich repeat	294..318	CDD:275380	7/23 (30%)
		LRR_8	319..378	CDD:290566	14/74 (19%)
		leucine-rich repeat	319..342	CDD:275380	6/22 (27%)
		leucine-rich repeat	343..367	CDD:275380	5/39 (13%)
		LRR_8	366..426	CDD:290566	10/59 (17%)
		leucine-rich repeat	368..391	CDD:275380	2/22 (9%)
		leucine-rich repeat	392..415	CDD:275380	3/22 (14%)
		LRR_8	414..471	CDD:290566	15/70 (21%)
		leucine-rich repeat	416..437	CDD:275380	4/24 (17%)
		leucine-rich repeat	440..463	CDD:275380	8/27 (30%)
		TIR_2	781..>861	CDD:290400	24/79 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020