DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr6

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_030110224.1	Gene:	Tlr6 / 21899	MGIID:	1341296	Length:	806	Species:	Mus musculus

Alignment Length:	876	Identity:	179/876 - (20%)
Similarity:	328/876 - (37%)	Gaps:	238/876 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 CNCSYNRD----------------------KSQLE--IDCWQKNLTTIPSLPVPKKGSSALVFQS 416
            ||.|.:|.                      .::||  :|...:|||.:|....|:  :.||....
Mouse    10 CNMSQDRKPIVGSFHFVCALALIVGSMTPFSNELESMVDYSNRNLTHVPKDLPPR--TKALSLSQ 72

  Fly   417 NLLAEL--PDNSLEGYHNLKSLDVSYNQLTSLS--VSQLPESLHYLDIRHNKITTLS--PQV-VE 474
            |.::||  ||.|.  ...|:.|.:|:|::.||.  |....:.|.|||:.||::..:|  |.. :.
Mouse    73 NSISELRMPDISF--LSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCPMASLR 135

  Fly   475 YL-YSVNVFN------QYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQ--------------T 518
            :| .|.|.|:      ::||               ..|...|.:..:||:              .
Mouse   136 HLDLSFNDFDVLPVCKEFGN---------------LTKLTFLGLSAAKFRQLDLLPVAHLHLSCI 185

  Fly   519 IMEYIELSSKGSFVENFFVQNIDQLYLEANEDEI--------IDAFGPSDKYFNLKLMEALNHAI 575
            :::.:....||...|:..:.|...|:|..:.:.:        ::|.|.. :..|:||.:.....:
Mouse   186 LLDLVSYHIKGGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHL-QLSNIKLNDENCQRL 249

  Fly   576 WLFSGEFD------EIILHHLNSPCPYRCSC---CFEWHTGEFLINCRNLSLDIYPRLPNSIPYK 631
            ..|..|..      .:.|.|:.:  .::||.   .|.|......:|..||::
Mouse   250 MTFLSELTRGPTLLNVTLQHIET--TWKCSVKLFQFFWPRPVEYLNIYNLTI------------- 299

  Fly   632 TTLYLDRNEIR-KLTNTESLVVA---------GHASIHKLHMSQNL----LRELP-LHLL----P 677
             |..:||.|.. ..|..:||::.         ...:::.:....|:    :.:.| :|::    |
Mouse   300 -TERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFIHMVCPPSP 363

  Fly   678 ENITYLDVRNNL-----------LKYLD------DGVIAFLE---YRENITKIE--------LSG 714
            .:.|:|:...|:           ||.|.      :|:..|.:   ..:|::.:|        |:.
Mouse   364 SSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNS 428

  Fly   715 NPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKEL 779
            :.::..|.....:..|.....|...:|.|               |:...     ..|:|.....:
Mouse   429 HAYDRTCAWAESILVLNLSSNMLTGSVFR---------------CLPPK-----VKVLDLHNNRI 473

  Fly   780 SEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPG---YSSVTRFYLAHNRLSDIDQLPDKLEYLDI 841
            ..||:..|.......|....|||..     |||   :||::...:.||.:|...:
Mouse   474 MSIPKDVTHLQALQELNVASNSLTD-----LPGCGAFSSLSVLVIDHNSVSHPSE---------- 523

  Fly   842 SNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANA--SAIQC- 903
                         .|.|...|...|...  .||:.|.||.:||:..:...|:.:...  .:.:|
Mouse   524 -------------DFFQSCQNIRSLTAG--NNPFQCTCELRDFVKNIGWVAREVVEGWPDSYRCD 573

  Fly   904 ---IDTGRSLIEVEETDI-CPSVLIYYTSLAVSLLIIALSINVFIC--FRQPIMIWFYEHEICLS 962
               ...|.:|.:...:.: |.:||:..| :..::|::|:: ..|:|  |..|   | |...:|..
Mouse   574 YPESSKGTALRDFHMSPLSCDTVLLTVT-IGATMLVLAVT-GAFLCLYFDLP---W-YVRMLCQW 632

  Fly   963 LAAR--------RELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYLRDWLVGESI 1018
            ...|        .||..:.::.||:|::..|...:: |.:..||  :...|:|.:.|:::.|:||
Mouse   633 TQTRHRARHIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLE--KDDIRVCLHERNFVPGKSI 695

  Fly  1019 PDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDV--EHFDDLDS 1081
            .:.|...::.|.:.|.:::.:|::|.|...|...|.|....:....||::|...:  .:......
Mouse   696 VENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNNIPSRYH 760

  Fly  1082 ELRAYMVLNTYLDRNNPN-----FWNKLMYS 1107
            :|||.|...|||:.....     ||..|..|
Mouse   761 KLRALMAQRTYLEWPTEKGKRGLFWANLRAS 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	4/31 (13%)
		leucine-rich repeat	388..408	CDD:275380	7/21 (33%)
		LRR_8	412..465	CDD:290566	20/56 (36%)
		leucine-rich repeat	412..432	CDD:275378	7/21 (33%)
		LRR_4	432..470	CDD:289563	14/41 (34%)
		leucine-rich repeat	433..454	CDD:275378	7/22 (32%)
		leucine-rich repeat	455..478	CDD:275378	9/26 (35%)
		leucine-rich repeat	479..490	CDD:275378	4/16 (25%)
		leucine-rich repeat	632..657	CDD:275378	7/34 (21%)
		leucine-rich repeat	658..679	CDD:275378	4/29 (14%)
		leucine-rich repeat	680..706	CDD:275378	8/45 (18%)
		leucine-rich repeat	707..719	CDD:275378	2/19 (11%)
		leucine-rich repeat	771..791	CDD:275380	5/19 (26%)
		leucine-rich repeat	793..815	CDD:275378	7/24 (29%)
		leucine-rich repeat	816..835	CDD:275378	3/18 (17%)
		leucine-rich repeat	836..859	CDD:275378	1/22 (5%)
		TIR	974..1110	CDD:214587	36/142 (25%)
Tlr6	XP_030110224.1	leucine-rich repeat	47..64	CDD:275380	5/16 (31%)
		PLN00113	50..>540	CDD:215061	109/575 (19%)
		leucine-rich repeat	65..88	CDD:275378	8/24 (33%)
		LRR_8	87..144	CDD:404697	18/56 (32%)
		leucine-rich repeat	89..112	CDD:275378	7/22 (32%)
		leucine-rich repeat	113..133	CDD:275378	8/19 (42%)
		leucine-rich repeat	134..158	CDD:275378	6/38 (16%)
		leucine-rich repeat	184..206	CDD:275380	3/21 (14%)
		leucine-rich repeat	207..230	CDD:275380	2/22 (9%)
		leucine-rich repeat	290..314	CDD:275380	7/37 (19%)
		leucine-rich repeat	315..343	CDD:275380	2/27 (7%)
		leucine-rich repeat	344..365	CDD:275380	3/20 (15%)
		leucine-rich repeat	390..415	CDD:275380	4/24 (17%)
		leucine-rich repeat	416..440	CDD:275380	3/23 (13%)
		leucine-rich repeat	441..462	CDD:275380	5/35 (14%)
		leucine-rich repeat	463..485	CDD:275380	5/21 (24%)
		leucine-rich repeat	486..508	CDD:275380	8/26 (31%)
		leucine-rich repeat	510..531	CDD:275380	5/43 (12%)
		LRRCT	540..594	CDD:214507	11/53 (21%)
		TIR	652..791	CDD:214587	35/140 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020