DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr4

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_067272.1	Gene:	Tlr4 / 21898	MGIID:	96824	Length:	835	Species:	Mus musculus

Alignment Length:	970	Identity:	207/970 - (21%)
Similarity:	371/970 - (38%)	Gaps:	304/970 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TNNYIRKTMNNTEKIKIYYHNTFEKTTL---------TMEKNIFHGKNKMSALIFNGLKIKGLTN 279
            |.| |..:.|..:.:|.|..:.|.:...         |:|...:||.:.:|.||..|..|:..:.
Mouse    55 TKN-IDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSP 118

  Fly   280 NTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYK 344
            .:|..||||                                :|:|.:::  |..:||...:.|..
Mouse   119 GSFSGLTSL--------------------------------ENLVAVET--KLASLESFPIGQLI 149

  Fly   345 GFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGS 409
            ..|                           |.|.::|                .|.|..:|
Mouse   150 TLK---------------------------KLNVAHN----------------FIHSCKLP---- 167

  Fly   410 SALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVE 474
               .:.|||.            ||..:|:|||.:.:::|:.|.      .:|.|....||..:
Mouse   168 ---AYFSNLT------------NLVHVDLSYNYIQTITVNDLQ------FLRENPQVNLSLDM-- 209

  Fly   475 YLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSF----VENF 535
               |:|..                 :|         |:...||.|..: ||:.:|:|    :...
Mouse   210 ---SLNPI-----------------DF---------IQDQAFQGIKLH-ELTLRGNFNSSNIMKT 244

  Fly   536 FVQNIDQLYL------EANEDEIIDAFGPSDKYFNLKLMEAL-----NHAIWLFSGEF-DEIILH 588
            .:||:..|::      |..::..::.|.||       :||.|     :.....::.:| |:|:..
Mouse   245 CLQNLAGLHVHRLILGEFKDERNLEIFEPS-------IMEGLCDVTIDEFRLTYTNDFSDDIVKF 302

  Fly   589 HLNSPCPYRCSCC----------------FEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLD 637
            |    |....|..                |:|.:.. :|.|:   |..:|.|  .:|:..:|.|.
Mouse   303 H----CLANVSAMSLAGVSIKYLEDVPKHFKWQSLS-IIRCQ---LKQFPTL--DLPFLKSLTLT 357

  Fly   638 RNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLE 702
            .|:             |..|..|:             .|| :::|||:..|.|.:  .|..::.:
Mouse   358 MNK-------------GSISFKKV-------------ALP-SLSYLDLSRNALSF--SGCCSYSD 393

  Fly   703 YREN-ITKIELSGNPWECNCKAKAFLSFLR-RHEPMEYETVLRRVEITDDKCPEDCICCVDTSNS 765
            ...| :..::||.|  .....:..|:.... :|...::.|:.|..|.:.....|. :..:|.|.:
Mouse   394 LGTNSLRHLDLSFN--GAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEK-LLYLDISYT 455

  Fly   766 DSLAYVVDCSGKELSEIPQLPTPTYGQTTL--------VFERNSLKKWPSSLLPGYSSVTRFYLA 822
            ::   .:|..|..|           |.|:|        .|:.|:|    |::....:::|...|:
Mouse   456 NT---KIDFDGIFL-----------GLTSLNTLKMAGNSFKDNTL----SNVFANTTNLTFLDLS 502

  Fly   823 HNRLSDI-----DQLPDKLEYLDISNNNFSALD-----------------DRV---RGFLQKRMN 862
            ..:|..|     |.| .:|:.|::|:||...||                 :|:   :|.|| ...
Mouse   503 KCQLEQISWGVFDTL-HRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQ-HFP 565

  Fly   863 SSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQC---IDTGRSLIEVEETDICPSVLI 924
            .|....:|..|...|.||.:.||.:||||.:.:.|...:.|   ::...||:.......|   .:
Mouse   566 KSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTC---YM 627

  Fly   925 YYTSLAVSLL-IIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSFTHKDEDL 988
            |.|.::||:: :|.:|...|:.:.      ||.|.|.:: ..::....:..||||:.::.::||.
Mouse   628 YKTIISVSVVSVIVVSTVAFLIYH------FYFHLILIA-GCKKYSRGESIYDAFVIYSSQNEDW 685

  Fly   989 I-EEFVDRLENGRHKFRLCFYLRDWLVGESI-PDCINQSVKGSRRIIILMTKNFLKSTWGRLEFR 1051
            : .|.|..||.|..:|.||.:.||::.|.:| .:.|.:....||::|::::::|::|.|...|:.
Mouse   686 VRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750

  Fly  1052 LALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVL--NTYLD-RNNP----NFWNKL 1104
            :|...........:|.::...||. ..|..::..|.:|  ||||: .:||    .||.:|
Mouse   751 IAQTWQFLSSRSGIIFIVLEKVEK-SLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRL 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..308	CDD:275380	1/19 (5%)
		leucine-rich repeat	309..334	CDD:275380	3/24 (13%)
		leucine-rich repeat	335..386	CDD:275380	7/50 (14%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		LRR_8	412..465	CDD:290566	13/52 (25%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	11/37 (30%)
		leucine-rich repeat	433..454	CDD:275378	7/20 (35%)
		leucine-rich repeat	455..478	CDD:275378	4/22 (18%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	4/24 (17%)
		leucine-rich repeat	658..679	CDD:275378	3/20 (15%)
		leucine-rich repeat	680..706	CDD:275378	6/25 (24%)
		leucine-rich repeat	707..719	CDD:275378	3/11 (27%)
		leucine-rich repeat	771..791	CDD:275380	3/19 (16%)
		leucine-rich repeat	793..815	CDD:275378	6/29 (21%)
		leucine-rich repeat	816..835	CDD:275378	6/23 (26%)
		leucine-rich repeat	836..859	CDD:275378	10/42 (24%)
		TIR	974..1110	CDD:214587	42/140 (30%)
Tlr4	NP_067272.1	LRR_8	53..113	CDD:290566	15/58 (26%)
		LRR 1	54..75		6/20 (30%)
		leucine-rich repeat	58..78	CDD:275380	5/19 (26%)
		LRR 2	78..99		2/20 (10%)
		leucine-rich repeat	79..102	CDD:275380	4/22 (18%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		LRR 4	126..147		7/54 (13%)
		leucine-rich repeat	127..150	CDD:275380	7/56 (13%)
		LRR_8	150..214	CDD:290566	24/136 (18%)
		LRR 5	150..171		7/70 (10%)
		leucine-rich repeat	151..175	CDD:275380	10/85 (12%)
		LRR 6	175..198		8/28 (29%)
		leucine-rich repeat	176..204	CDD:275380	9/33 (27%)
		LRR 7	204..224		7/50 (14%)
		leucine-rich repeat	205..226	CDD:275380	8/51 (16%)
		LRR 8	226..247		4/21 (19%)
		LRR 9	248..269		3/20 (15%)
		LRR 10	329..349		6/25 (24%)
		leucine-rich repeat	331..350	CDD:275380	5/24 (21%)
		LRR 11	350..370		6/45 (13%)
		leucine-rich repeat	351..372	CDD:275380	8/47 (17%)
		LRR_RI	<369..555	CDD:238064	44/210 (21%)
		LRR 12	372..392		6/21 (29%)
		leucine-rich repeat	373..398	CDD:275380	6/26 (23%)
		LRR 13	398..420		4/23 (17%)
		leucine-rich repeat	399..421	CDD:275380	4/23 (17%)
		LRR 14	421..442		4/20 (20%)
		leucine-rich repeat	422..446	CDD:275380	4/23 (17%)
		LRR 15	446..467		5/35 (14%)
		leucine-rich repeat	447..470	CDD:275380	6/36 (17%)
		LRR 16	470..490		5/23 (22%)
		leucine-rich repeat	471..495	CDD:275380	5/27 (19%)
		LRR_8	494..554	CDD:290566	13/60 (22%)
		LRR 17	495..516		4/20 (20%)
		leucine-rich repeat	496..519	CDD:275380	6/23 (26%)
		LRR 18	519..540		7/20 (35%)
		leucine-rich repeat	520..543	CDD:275380	7/22 (32%)
		LRR 19	543..564		4/21 (19%)
		Interaction with SCIMP. /evidence=ECO:0000269\|PubMed:28098138	670..835		42/141 (30%)
		TIR	672..813	CDD:214587	42/139 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920