| Sequence 1: | NP_523519.2 | Gene: | Toll-4 / 34235 | FlyBaseID: | FBgn0032095 | Length: | 1125 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001263374.1 | Gene: | Tlr1 / 21897 | MGIID: | 1341295 | Length: | 795 | Species: | Mus musculus |
| Alignment Length: | 903 | Identity: | 181/903 - (20%) |
|---|---|---|---|
| Similarity: | 321/903 - (35%) | Gaps: | 287/903 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 360 HCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELP 423
Fly 424 DNSLEGYHNLKSLDVSYNQLTSLSVS--QLPESLHYLDIRHN--KITTLSPQV-VEYL-YSVNVF 482
Fly 483 N------QYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNID 541
Fly 542 QLYLEANEDEII----DAFGPSDKYFNLKLM--EALNHAIWLFSGEFDEII---------LHHLN 591
Fly 592 SPCPYRCSCC------------------------------------FEWHTGEFLINCRNLSLDI 620
Fly 621 YPRLPNSIPYKTTLYLDRNEIRKLT-----------------------NTESLVVAGHASIHKLH 662
Fly 663 MSQ-----------------------NLLRELPLHLLP------ENITY----------LDVRNN 688
Fly 689 LLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCP 753
Fly 754 EDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPG---YSS 815
Fly 816 VTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCE 880
Fly 881 DKDFLVFVKEQAKNIANA--SAIQC----IDTGRSLIEVEETDI-CPSVLIYYTSLAVSLLIIAL 938
Fly 939 SINVFIC--FRQPIMIWFYEHEICLSLAAR--------RELDEDKKYDAFLSFTHKDEDLIE-EF 992
Fly 993 VDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHAT 1057
Fly 1058 SRDRCKRLIVVLYPDVEHFDDLDS--ELRAYMVLNTYL----DRNNPN-FWNKLMYSM 1108 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Toll-4 | NP_523519.2 | leucine-rich repeat | 264..287 | CDD:275380 | |
| leucine-rich repeat | 288..308 | CDD:275380 | |||
| leucine-rich repeat | 309..334 | CDD:275380 | |||
| leucine-rich repeat | 335..386 | CDD:275380 | 5/25 (20%) | ||
| leucine-rich repeat | 388..408 | CDD:275380 | 7/20 (35%) | ||
| LRR_8 | 412..465 | CDD:290566 | 18/56 (32%) | ||
| leucine-rich repeat | 412..432 | CDD:275378 | 4/19 (21%) | ||
| LRR_4 | 432..470 | CDD:289563 | 15/41 (37%) | ||
| leucine-rich repeat | 433..454 | CDD:275378 | 8/22 (36%) | ||
| leucine-rich repeat | 455..478 | CDD:275378 | 10/26 (38%) | ||
| leucine-rich repeat | 479..490 | CDD:275378 | 4/16 (25%) | ||
| leucine-rich repeat | 632..657 | CDD:275378 | 5/47 (11%) | ||
| leucine-rich repeat | 658..679 | CDD:275378 | 9/49 (18%) | ||
| leucine-rich repeat | 680..706 | CDD:275378 | 8/35 (23%) | ||
| leucine-rich repeat | 707..719 | CDD:275378 | 3/11 (27%) | ||
| leucine-rich repeat | 771..791 | CDD:275380 | 5/19 (26%) | ||
| leucine-rich repeat | 793..815 | CDD:275378 | 7/24 (29%) | ||
| leucine-rich repeat | 816..835 | CDD:275378 | 3/18 (17%) | ||
| leucine-rich repeat | 836..859 | CDD:275378 | 1/22 (5%) | ||
| TIR | 974..1110 | CDD:214587 | 34/143 (24%) | ||
| Tlr1 | NP_001263374.1 | PRK15370 | <38..>133 | CDD:185268 | 31/97 (32%) |
| LRR | <48..317 | CDD:227223 | 58/314 (18%) | ||
| leucine-rich repeat | 50..73 | CDD:275378 | 4/22 (18%) | ||
| LRR 1 | 54..77 | 4/22 (18%) | |||
| leucine-rich repeat | 74..97 | CDD:275378 | 8/22 (36%) | ||
| LRR 2 | 78..101 | 7/22 (32%) | |||
| leucine-rich repeat | 98..118 | CDD:275378 | 8/19 (42%) | ||
| LRR 3 | 102..125 | 7/22 (32%) | |||
| leucine-rich repeat | 119..143 | CDD:275378 | 6/52 (12%) | ||
| LRR 4 | 126..150 | 4/52 (8%) | |||
| leucine-rich repeat | 144..156 | CDD:275378 | 5/13 (38%) | ||
| LRR 5 | 151..175 | 8/27 (30%) | |||
| LRR 6 | 176..199 | 7/23 (30%) | |||
| LRR 7 | 200..223 | 3/22 (14%) | |||
| LRR 8 | 224..250 | 2/25 (8%) | |||
| LRR 9 | 251..278 | 3/26 (12%) | |||
| LRR 10 | 279..308 | 5/35 (14%) | |||
| LRR 11 | 309..337 | 1/27 (4%) | |||
| Interaction with bacterial lipopeptide. /evidence=ECO:0000250 | 316..319 | 0/2 (0%) | |||
| LRR 12 | 338..361 | 5/22 (23%) | |||
| leucine-rich repeat | 355..376 | CDD:275380 | 2/20 (10%) | ||
| LRR 13 | 362..388 | 5/25 (20%) | |||
| PRK15370 | <377..>487 | CDD:185268 | 28/156 (18%) | ||
| leucine-rich repeat | 377..402 | CDD:275380 | 5/24 (21%) | ||
| LRR 14 | 389..414 | 6/24 (25%) | |||
| leucine-rich repeat | 403..427 | CDD:275380 | 7/25 (28%) | ||
| LRR 15 | 415..437 | 6/43 (14%) | |||
| leucine-rich repeat | 428..449 | CDD:275380 | 7/55 (13%) | ||
| LRR 16 | 438..457 | 5/38 (13%) | |||
| leucine-rich repeat | 450..472 | CDD:275380 | 5/21 (24%) | ||
| LRR 17 | 458..478 | 4/19 (21%) | |||
| leucine-rich repeat | 473..494 | CDD:275380 | 7/25 (28%) | ||
| LRR 18 | 479..500 | 8/25 (32%) | |||
| leucine-rich repeat | 495..518 | CDD:275380 | 5/45 (11%) | ||
| LRR 19 | 501..524 | 7/45 (16%) | |||
| LRRCT | 527..581 | CDD:214507 | 11/53 (21%) | ||
| TIR | 639..782 | CDD:214587 | 34/143 (24%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG4641 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D147327at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000239 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR24365 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X221 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 6 | 5.920 | |||||