DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and egg-6

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	980	Identity:	189/980 - (19%)
Similarity:	325/980 - (33%)	Gaps:	328/980 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 CNETDYELVI-------ISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLIT-----E 197
            ||..|.:.:.       |..|.|.:..|::|    :.|...|:|.|:..:..|.|...|     |
Worm    43 CNGEDVKTIAQTVGTSQIDELHILNGTDVKI----ESLPFNGLRTIAILNSTLQSFSPTAWRHVE 103

  Fly   198 MDVHH--ANGPKMVT------FKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTME 254
            ..:.|  .||.::.|      ...|....:||...::...|..|....:          |.|.:|
Worm   104 ATIEHITINGNELKTVPVFGNLSTLMSMNLNSNQISSIPDKAFNGLSAL----------TQLRLE 158

  Fly   255 KNI---FHGKN----KMSALIF----NGLK------IKGLTNNTFENLTSLNTLIFDNVFLKDLS 302
            .|.   |..|:    |.|.::.    |.|.      ::...|..:.:|.|.|....:|..|.:|.
Worm   159 NNAICDFPPKSLDAVKASLVLLDVSGNCLDAIPAQILRNAANLMYLDLGSNNISEINNFELMNLP 223

  Fly   303 FLRSSTLQSS---------------LTYCIMKVDNMV---DLKSFEKFTNLEIIEVSQYKGFKNF 349
            |||...:|::               |.|..:: ||::   |....:.|.|||:::||      |.
Worm   224 FLRELRVQNNTLRRIHPMAFMNVPQLQYLYLQ-DNIISTLDGNRLQGFKNLEVLDVS------NN 281

  Fly   350 TAFICEPYKS--HCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGS--- 409
            ..:.....|.  :.|.......:...::.....|....|| |.....|:..|      .:.|
Worm   282 ALYALPSLKDLPNLKQVRVDGNLITKIETLAFSNNPNLQL-ISVQNNNIVQI------SRNSFES 339

  Fly   410 ----SALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHY--LDIRHNKITTL 468
                ..|:..:|.||::.....:|..||:.|.:..|.||:|..|...:..|.  ||:.||||..:
Worm   340 LDKLVVLLVGNNSLAKIERGMFDGMKNLQQLSIRNNTLTALDASSFAQLAHLTTLDLGHNKIHDI 404

  Fly   469 SPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWY---KAKLLRIKTSKFQTIMEYIELSSKGS 530
            ..         ..|::             |.:.||.   ..|:...|||.|:..:..|.|.....
Worm   405 EE---------GTFDK-------------LSKLFWLDLSNNKISGFKTSVFKKKISNILLDGNQL 447

  Fly   531 FVENFFVQNIDQLYLEAN--------EDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIIL 587
            ..:..|  |....||.||        :.||: ..|| :||..::|.:       |...:.:|.:
Worm   448 ICDESF--NEFLTYLIANKVRTFLPFQQEIM-CHGP-EKYAGVRLKD-------LMMKKANETL- 500

  Fly   588 HHLNSPCPYRCSCCFEWHTGEFLI------NCRNLSLDIYPRL----------PNSIPYKTTLYL 636
                             ..|..|:      |..:|.....|.|          ..:||...||
Worm   501 -----------------SEGSRLLGVPQGSNQHSLLSSFLPSLGPLGTLNGAGGAAIPLVNTL-- 546

  Fly   637 DRNEIRKLTNTESL-----VVAGHASIHKLHMS------------------------QNLLRELP 672
             .|.|..|.:....     |..|.:|:...:::                        :.|:|.:|
Worm   547 -TNTIPALRSIPGFGGNIPVGTGASSVPNKNLNDAIEGFTGPLVRFATGGQPVASDIEQLIRSIP 610

  Fly   673 LHLL--------------PENITYLDVRNNLLKYLDDGVIAFLE-------YRENITKI------ 710
            ..::              |..|.|:         |:.|.|..::       .::.:.|:
Worm   611 NMVVNVPGFGDIDLSKMDPTMIQYV---------LNGGQIPGIDKATLDKIVKQTMNKMHTAAAA 666

  Fly   711 ELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTS------NSDSLA 769
            .|:|||.|                  ..|.||..:    ||.|...:..|.:.      |.:...
Worm   667 NLAGNPVE------------------GQEKVLPPL----DKLPSGLVTQVMSGEPLPGLNENQTK 709

  Fly   770 YVVDCSGKE---LSEIPQLPTPTYGQTT-------LVFERNSLKKWPSSLLPGY----------S 814
            .:::....:   :..||..|..:.|.||       .:|:  .||..|    |||          :
Worm   710 IIMEYYTHQMPGMDGIPARPVESQGNTTANNMFNPAMFD--LLKMLP----PGYNLSKIPMEVIA 768

  Fly   815 SVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQL--QLSLFGNPWTC 877
            :|||     ..:.|:..||:.|  |:....:.::|.....|...|.::..::  :|.:|..|
Worm   769 AVTR-----GEVPDMRLLPEDL--LEHFKQHTTSLTSMFAGATAKNISIEEILEKLPVFVRP--- 823

  Fly   878 RCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVEETD------ICPSVLIYYTSLAVSLLII 936
                 :...||......:          |...::|.|:.:      |..::.:.:.. ||::::|
Worm   824 -----ELSTFVPYDINEL----------TSEMVLEQEQNERHRNIRIITAIALAFVG-AVTVVVI 872

  Fly   937 ALSIN 941
            ...:|
Worm   873 IFFVN 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	5/32 (16%)
		leucine-rich repeat	288..308	CDD:275380	7/19 (37%)
		leucine-rich repeat	309..334	CDD:275380	7/42 (17%)
		leucine-rich repeat	335..386	CDD:275380	8/52 (15%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		LRR_8	412..465	CDD:290566	18/54 (33%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	15/39 (38%)
		leucine-rich repeat	433..454	CDD:275378	7/20 (35%)
		leucine-rich repeat	455..478	CDD:275378	7/24 (29%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	7/29 (24%)
		leucine-rich repeat	658..679	CDD:275378	4/58 (7%)
		leucine-rich repeat	680..706	CDD:275378	5/32 (16%)
		leucine-rich repeat	707..719	CDD:275378	5/17 (29%)
		leucine-rich repeat	771..791	CDD:275380	3/22 (14%)
		leucine-rich repeat	793..815	CDD:275378	9/38 (24%)
		leucine-rich repeat	816..835	CDD:275378	6/18 (33%)
		leucine-rich repeat	836..859	CDD:275378	4/22 (18%)
		TIR	974..1110	CDD:214587
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	13/64 (20%)
		leucine-rich repeat	107..127	CDD:275380	4/19 (21%)
		leucine-rich repeat	128..151	CDD:275380	5/22 (23%)
		LRR_RI	<144..281	CDD:238064	34/153 (22%)
		leucine-rich repeat	152..200	CDD:275380	10/57 (18%)
		LRR_8	176..233	CDD:290566	14/56 (25%)
		leucine-rich repeat	201..224	CDD:275380	6/22 (27%)
		LRR_8	225..283	CDD:290566	15/64 (23%)
		leucine-rich repeat	225..248	CDD:275380	3/22 (14%)
		LRR_RI	<240..458	CDD:238064	54/255 (21%)
		leucine-rich repeat	249..272	CDD:275380	6/23 (26%)
		LRR_8	271..329	CDD:290566	12/64 (19%)
		leucine-rich repeat	273..294	CDD:275380	6/26 (23%)
		leucine-rich repeat	295..318	CDD:275380	2/22 (9%)
		LRR_8	317..375	CDD:290566	14/64 (22%)
		leucine-rich repeat	319..342	CDD:275380	6/29 (21%)
		leucine-rich repeat	343..366	CDD:275380	5/22 (23%)
		LRR_8	365..425	CDD:290566	19/81 (23%)
		leucine-rich repeat	367..390	CDD:275380	7/22 (32%)
		leucine-rich repeat	391..414	CDD:275380	8/44 (18%)
		leucine-rich repeat	415..434	CDD:275380	6/18 (33%)
		leucine-rich repeat	437..449	CDD:275378	2/11 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910