DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tol-1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001020983.1	Gene:	tol-1 / 171635	WormBaseID:	WBGene00006593	Length:	1221	Species:	Caenorhabditis elegans

Alignment Length:	1137	Identity:	231/1137 - (20%)
Similarity:	421/1137 - (37%)	Gaps:	335/1137 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 EKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLS--------- 302
            ||.:||..:||...:..:.:|  ..|::..:::|...:|....:.:...:.:.|||
Worm   149 EKFSLTRSRNIELPQRLLCSL--PHLQVLNISSNELPSLRREESCVAQQLLIVDLSRNRLTNIEQ 211

  Fly   303 FLRS--STLQSSLTY-CIMKVDNMVD---LKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHC 361
            |||.  :..|.|:.| .|.::|..:.   |:..:...| .|::::...|............|
Worm   212 FLRGIPAIRQISVAYNSIAELDLSLATPFLQQLDAEAN-RIVDLTSLPGTVVHVNLAGNALK--- 272

  Fly   362 KFTLGINEVACPLKCNCSYNRDK-------SQLEIDCWQKNLTTIPSLPVP-----KKGSSALVF 414
            :....:.|:|..:..|.|.|..:       |..|::....:...:.||||.     :|..:.|..
Worm   273 RVPDAVAELASLVALNVSRNEIEAGNSSVFSSPELEMLDASYNKLDSLPVEWLQKCEKRIAHLHL 337

  Fly   415 QSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPES------------------------- 454
            :.|.:.:|....|....||::||:|.|||.......|||:
Worm   338 EHNSIEQLTGGVLANATNLQTLDLSSNQLRVFRDEVLPENSKIGNLRLSNNSLELLEPSSLSGLK 402

  Fly   455 LHYLDIRHNKITTLSPQV--VEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLR---IKTS 514
            |..||:.|||:|.:...:  ||.|..|::  .:.....:|  :|.|.     |.|.|.   :..:
Worm   403 LESLDLSHNKLTEVPAAIGKVEQLKKVDL--SHNRIAKVY--QYVLN-----KIKQLHTVDLSNN 458

  Fly   515 KFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEII--DAFG--PSDKYFNLKL--MEALNH 573
            :.|:|..||       |.::..:.::|   :..||..::  |||.  |..:..::|:  :::|:.
Worm   459 QLQSIGPYI-------FSDSSELHSLD---VSNNEISLLFKDAFARCPKLRKISMKMNKIKSLDE 513

  Fly   574 AIWLFSG------EFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKT 632
            .:...||      ..:||::              .:|..                 ||.::   .
Worm   514 GLTEASGLRRLDVSHNEILV--------------LKWSA-----------------LPENL---E 544

  Fly   633 TLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGV 697
            .|..|.|:|..|  |.:.:....|::..:.:|.|.:..:....:|.::..|||.||.|..|....
Worm   545 ILNADNNDINLL--TAASMSPSTANLKSVSLSNNGITIMNADQIPNSLESLDVSNNRLAKLGKTA 607

  Fly   698 IAF------LEYRENI-----------------TKIELSGNPWECNC---------KAKAFLSFL 730
            :|.      |..:.|:                 .|:|:|.||..|:|         |.|..:...
Worm   608 LAAKSQLRRLNLKGNLLTVVATESMKVVEAVHPLKVEISENPLICDCQMGWMIGGAKPKVLIQDS 672

  Fly   731 R----RHEPMEYETVLRRVEITDDKCP------EDCICCVDTSNSDSLAY--------------- 770
            .    .|....::..::.:...|..||      .:|||| ...|.|..:.
Worm   673 ETASCSHAVDGHQIQIQSLSKKDLLCPYKSVCEPECICC-QYGNCDCKSVCPANCRCFRDDQFNI 736

  Fly   771 -VVDCSGKE---------LSE--------------IPQLPTPTY--------------------- 790
             :|.|.|..         :||              :|||.|.::
Worm   737 NIVRCHGNSSMVPKREFVVSELPVSATEIILSGVTLPQLRTHSFIGRLRLQRLHINGTGLRSIQP 801

  Fly   791 -------GQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDI-----DQLPDKLEYLDISN 843
                   ...||....|||.............|::.:|..||.|.:     ::||: |:||.:.|
Worm   802 KAFHTLPALKTLDLSDNSLISLSGEEFLKCGEVSQLFLNGNRFSTLSRGIFEKLPN-LKYLTLHN 865

  Fly   844 NNFSALDDRVRGFLQKRMNSSQL-QLSLFGNPWTCRC-----------EDKDFLVFVKEQAKN-- 894
            |   :|:|     :.:.::|:.| ::||..||..|.|           .|.....|.:..|..
Worm   866 N---SLED-----IPQVLHSTALSKISLSSNPLRCDCSGGSQQHLHHRRDPKAHPFWEHNAAEWF 922

  Fly   895 ------IANASAIQCIDT--------------------GRS--LIEVEE--TDICPSVLIYYTS- 928
                  :.:...::|.:.                    |..  ::.:||  .|...::.:.::|
Worm   923 SLHRHLVVDFPKVECWENVTKAFLTNDTTVLSAYPPNMGNDVFVMPIEEFLRDYNSTICVPFSSG 987

  Fly   929 -------LAVSLLIIALSINVFICFRQPIMIWFY--EHEI------------CLSLAARRELDED 972
                   .::..:||.:||.|.:|....:.|.|.  .|:.            |.:.|....|...
Worm   988 FFGQDPQNSILFVIITISIAVLLCVLVILAISFIRKSHDAINQRRYKASSLNCSTSAGSSPLPVP 1052

  Fly   973 -KKYDAFLSFTHKDEDL-IEEFVDRLENGRHKFRLCFYLRDWLVG-------ESIPDCINQSVKG 1028
             ..|.||:|::.|||.: |::....||:  ..::||...||   |       .:|.|.:...:..
Worm  1053 LLSYHAFVSYSKKDEKMVIDQLCRPLED--EDYQLCLLHRD---GPTYCSNLHAISDELIAQMDS 1112

  Fly  1029 SRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYL 1093
            |:.:|:::||:||::.|..|:.:.:....:::|.||:|.||...|: .:.||.||...:..:|.:
Worm  1113 SQCLILVLTKHFLENEWKTLQIKTSHQLFAKNRAKRVIAVLGDGVD-ANLLDDELGQILRKHTRI 1176

  Fly  1094 DRNNPNFWNKLMYSMPHASHLKRSRSDAETKV 1125
            :..:..||..|..|:|....|..:..|..:::
Worm  1177 EMRSHLFWTLLHSSLPSRLPLPSNSGDDSSQL 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..308	CDD:275380	6/30 (20%)
		leucine-rich repeat	309..334	CDD:275380	6/28 (21%)
		leucine-rich repeat	335..386	CDD:275380	8/57 (14%)
		leucine-rich repeat	388..408	CDD:275380	5/24 (21%)
		LRR_8	412..465	CDD:290566	20/77 (26%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	18/62 (29%)
		leucine-rich repeat	433..454	CDD:275378	9/20 (45%)
		leucine-rich repeat	455..478	CDD:275378	10/24 (42%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	6/24 (25%)
		leucine-rich repeat	658..679	CDD:275378	3/20 (15%)
		leucine-rich repeat	680..706	CDD:275378	9/31 (29%)
		leucine-rich repeat	707..719	CDD:275378	5/28 (18%)
		leucine-rich repeat	771..791	CDD:275380	9/70 (13%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	7/23 (30%)
		leucine-rich repeat	836..859	CDD:275378	7/22 (32%)
		TIR	974..1110	CDD:214587	41/143 (29%)
tol-1	NP_001020983.1	leucine-rich repeat	71..95	CDD:275380
		leucine-rich repeat	96..119	CDD:275380
		leucine-rich repeat	120..171	CDD:275380	7/23 (30%)
		leucine-rich repeat	172..195	CDD:275380	3/22 (14%)
		leucine-rich repeat	196..283	CDD:275380	17/90 (19%)
		leucine-rich repeat	219..240	CDD:275378	5/20 (25%)
		leucine-rich repeat	241..258	CDD:275378	3/17 (18%)
		LRR	265..600	CDD:227223	81/392 (21%)
		leucine-rich repeat	287..306	CDD:275380	4/18 (22%)
		leucine-rich repeat	307..331	CDD:275380	4/23 (17%)
		leucine-rich repeat	332..355	CDD:275380	4/22 (18%)
		leucine-rich repeat	356..379	CDD:275380	10/22 (45%)
		leucine-rich repeat	380..395	CDD:275380	0/14 (0%)
		leucine-rich repeat	403..425	CDD:275380	8/21 (38%)
		leucine-rich repeat	426..449	CDD:275380	6/31 (19%)
		leucine-rich repeat	450..473	CDD:275380	6/29 (21%)
		leucine-rich repeat	474..497	CDD:275380	6/25 (24%)
		leucine-rich repeat	498..520	CDD:275380	2/21 (10%)
		leucine-rich repeat	543..567	CDD:275380	6/28 (21%)
		leucine-rich repeat	568..589	CDD:275380	3/20 (15%)
		leucine-rich repeat	590..613	CDD:275380	8/22 (36%)
		leucine-rich repeat	614..633	CDD:275380	2/18 (11%)
		leucine-rich repeat	763..785	CDD:275378	4/21 (19%)
		LRR_8	785..844	CDD:338972	8/58 (14%)
		leucine-rich repeat	786..809	CDD:275378	0/22 (0%)
		LRR_9	<806..>890	CDD:373143	24/92 (26%)
		leucine-rich repeat	810..833	CDD:275378	5/22 (23%)
		leucine-rich repeat	834..857	CDD:275378	6/22 (27%)
		leucine-rich repeat	858..879	CDD:275378	8/28 (29%)
		leucine-rich repeat	880..892	CDD:275378	5/11 (45%)
		TIR_2	1056..1194	CDD:390066	42/143 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I6371
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820