DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and Il1rl2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_598259.2	Gene:	Il1rl2 / 171106	RGDID:	621782	Length:	561	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	107/636 - (16%)
Similarity:	228/636 - (35%)	Gaps:	213/636 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 IWLFSGEFDEIILHH----LNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNS-------- 627
            :::.:|...::.:||    ...|.|:.|:                     ||.:.|.
  Rat    17 LFVAAGNCTDVYMHHEMISEGQPFPFNCT---------------------YPPVTNGAVNLTWHR 60

  Fly   628 IPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRN----- 687
            .|.|:.:.::|:.                   ::|..|:.:..|||.|....|....:::
  Rat    61 TPSKSPISINRHV-------------------RIHQDQSWILFLPLALEDSGIYQCVIKDAHSCY 106

  Fly   688 ----NLLKYL---------DDGVIAFLEYRENITKIELSGN-------PWECNCKAKAFLSFLRR 732
                ||..:.         :..:.:..||::.: .|..||:       |..|      .|..::.
  Rat   107 RIAINLTVFRKHWCDSSNEESSINSSDEYQQWL-PIGKSGSLTCHLYFPESC------VLDSIKW 164

  Fly   733 HEPMEYETVLRRVEITDDKCPED---CICCVDTSNSDSLAYVVDCSG------------------ 776
            ::..|      .::::...||..   .:..:|..:|.|.|    ||.
  Rat   165 YKGCE------EIKVSKKFCPTGTKLLVNNIDVEDSGSYA----CSARLTHLGRIFTVRNYIAVN 219

  Fly   777 -KELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVT--------RFYLAHNRLSDIDQL 832
             ||:....::|..||.      :.||::....|.|....::|        |.:..:|.|.| |..
  Rat   220 TKEVGSGGRIPNITYP------KNNSIEVQLGSTLIVDCNITDTKENTNLRCWRVNNTLVD-DYY 277

  Fly   833 PDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSL--FGNPWTCRCEDKDFLVFVKEQAKNI 895
            .|.....:....|.|     :|..:...:|.:.|::.:  :|:|:||........:.:|..|
  Rat   278 NDSKRIQEGIETNLS-----LRNHILYTVNITFLEVKMEDYGHPFTCHAGVSAAYIILKRPA--- 334

  Fly   896 ANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSI-NVFICFRQPIMIWFYEHEI 959
                                    |....|.....::.|::|:|| .::..|:..|::|:..
  Rat   335 ------------------------PDFRAYLIGGLMAFLLLAVSILYIYNTFKVDIVLWYRS--- 372

  Fly   960 CLSLAARRELDEDKKYDAFLSFT--------HKDEDLIEEFVDRLENGRHKFRLCFYLRDWLVGE 1016
              :....:..|::|.|||::.:.        |..:.|:.:.:..:...:..::|..:.||...|:
  Rat   373 --TFHTAQAPDDEKLYDAYVLYPKYPRESQGHDVDTLVLKILPEVLEKQCGYKLFIFGRDEFPGQ 435

  Fly  1017 SIPDCINQSVKGSRRIIILMTK-----NFLKSTWGRLEFRLALH-ATSRDRCKRLIVVLYPDVEH 1075
            ::...|::::|..||:::|:..     :|||:.   .|.::|:: |..:|..|.:::.| ..|:.
  Rat   436 AVASVIDENIKLCRRLMVLVAPETSSFSFLKNL---TEEQIAVYNALVQDGMKVILIEL-ERVKD 496

  Fly  1076 FDDLDSELRAYMVLNTYLDRNN-----------------PNFWNKLMYSMP 1109
            :..:...::       |:.:.:                 ..||.|:.|.||
  Rat   497 YSTMPESIQ-------YIRQKHGAIQWDGDFTEQAQCAKTKFWKKVRYHMP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	1/24 (4%)
		leucine-rich repeat	658..679	CDD:275378	6/20 (30%)
		leucine-rich repeat	680..706	CDD:275378	5/43 (12%)
		leucine-rich repeat	707..719	CDD:275378	4/18 (22%)
		leucine-rich repeat	771..791	CDD:275380	6/38 (16%)
		leucine-rich repeat	793..815	CDD:275378	4/21 (19%)
		leucine-rich repeat	816..835	CDD:275378	6/26 (23%)
		leucine-rich repeat	836..859	CDD:275378	3/22 (14%)
		TIR	974..1110	CDD:214587	31/167 (19%)
Il1rl2	NP_598259.2	Ig	26..115	CDD:416386	20/128 (16%)
		Ig strand A'	31..35	CDD:409353	1/3 (33%)
		Ig strand B	39..44	CDD:409353	2/4 (50%)
		Ig strand C	55..59	CDD:409353	0/3 (0%)
		Ig strand C'	64..66	CDD:409353	1/1 (100%)
		Ig strand D	74..78	CDD:409353	1/3 (33%)
		Ig strand E	80..84	CDD:409353	0/3 (0%)
		Ig strand F	93..101	CDD:409353	1/7 (14%)
		Ig strand G	104..115	CDD:409353	2/10 (20%)
		Ig	133..222	CDD:416386	17/105 (16%)
		Ig strand A	135..140	CDD:409353	1/5 (20%)
		Ig strand B	145..149	CDD:409353	1/3 (33%)
		Ig strand C	161..166	CDD:409353	0/4 (0%)
		Ig strand C'	169..171	CDD:409353	1/7 (14%)
		Ig strand D	176..180	CDD:409353	1/3 (33%)
		Ig strand E	182..187	CDD:409353	0/4 (0%)
		Ig strand F	196..205	CDD:409353	4/12 (33%)
		Ig strand G	208..221	CDD:409353	0/12 (0%)
		Ig	230..330	CDD:416386	23/111 (21%)
		Ig strand A	230..233	CDD:409353	1/2 (50%)
		Ig strand A'	238..241	CDD:409353	2/2 (100%)
		Ig strand B	246..255	CDD:409353	2/8 (25%)
		Ig strand C	262..268	CDD:409353	1/5 (20%)
		Ig strand C'	270..273	CDD:409353	1/2 (50%)
		Ig strand E	296..303	CDD:409353	0/6 (0%)
		Ig strand G	322..330	CDD:409353	0/7 (0%)
		TIR	389..539	CDD:396246	26/160 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910