DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and Il1rl1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001020773.1	Gene:	Il1rl1 / 17082	MGIID:	98427	Length:	567	Species:	Mus musculus

Alignment Length:	613	Identity:	117/613 - (19%)
Similarity:	214/613 - (34%)	Gaps:	186/613 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 CPYRCSCCF--EWHTGEFLINCRNLSLDIYPRLPNSIP--YKTTLYLDRNEIRKL---------- 644
            ||.|....:  ||:               |.....|||  .:..:::.|:.::.|
Mouse    42 CPQRGRSTYPVEWY---------------YSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIY 91

  Fly   645 ---TNTESLVVAGH--ASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYR 704
               ..:.:|...|:  .:|||...|.|         :|:.:.|..||.:     |.      .::
Mouse    92 ACVIRSPNLNKTGYLNVTIHKKPPSCN---------IPDYLMYSTVRGS-----DK------NFK 136

  Fly   705 ENITKIEL----SGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNS 765
            .....|:|    :...|..||||      |:......:.:.|....:|.|  .|....|..|...
Mouse   137 ITCPTIDLYNWTAPVQWFKNCKA------LQEPRFRAHRSYLFIDNVTHD--DEGDYTCQFTHAE 193

  Fly   766 DSLAYVVDCS------GKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHN 824
            :...|:|..:      .|..|..|.:..|.|..|..|    .:.| |:|:    :....|....:
Mouse   194 NGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEV----EIGK-PASI----ACSACFGKGSH 249

  Fly   825 RLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVK 889
            .|:|:                                 ..|:..::.||....|.::
Mouse   250 FLADV---------------------------------LWQINKTVVGNFGEARIQE-------- 273

  Fly   890 EQAKNIANASAIQCIDTGRSLIEVEETDI-----CPSV---------------------LIYYTS 928
            |:.:|.::::.:.|:.:...:..|.|.|:     |.::                     .|||..
Mouse   274 EEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHRSIYYIV 338

  Fly   929 LAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSF----------TH 983
            ...|||::.:::.|.:.....|.:..:..:|......|   ::.|.|||::.:          ||
Mouse   339 AGCSLLLMFINVLVIVLKVFWIEVALFWRDIVTPYKTR---NDGKLYDAYIIYPRVFRGSAAGTH 400

  Fly   984 KDEDLIEEFV-----DRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKS 1043
            .    :|.||     |.||| :..::||.|.||.|.|:.....:..|::.|||.:.::..:.:.|
Mouse   401 S----VEYFVHHTLPDVLEN-KCGYKLCIYGRDLLPGQDAATVVESSIQNSRRQVFVLAPHMMHS 460

  Fly  1044 TWGRLEFRLALH-ATSRDRCKRLIVVLYPDVE----HFDDLDSELRAYMVLNTYL--------DR 1095
            .....|..:||| |..::..|.:::.:.|..|    ...||...|:..:.:...:        |:
Mouse   461 KEFAYEQEIALHSALIQNNSKVILIEMEPLGEASRLQVGDLQDSLQHLVKIQGTIKWREDHVADK 525

  Fly  1096 N--NPNFWNKLMYSMPHASHLKRSRSDA 1121
            .  :..||..:.|.||......::.|.|
Mouse   526 QSLSSKFWKHVRYQMPVPERASKTASVA 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	4/39 (10%)
		leucine-rich repeat	658..679	CDD:275378	6/20 (30%)
		leucine-rich repeat	680..706	CDD:275378	4/25 (16%)
		leucine-rich repeat	707..719	CDD:275378	3/15 (20%)
		leucine-rich repeat	771..791	CDD:275380	5/25 (20%)
		leucine-rich repeat	793..815	CDD:275378	5/21 (24%)
		leucine-rich repeat	816..835	CDD:275378	3/18 (17%)
		leucine-rich repeat	836..859	CDD:275378	0/22 (0%)
		TIR	974..1110	CDD:214587	40/165 (24%)
Il1rl1	NP_001020773.1	Ig	33..97	CDD:416386	11/69 (16%)
		Ig strand B	37..42	CDD:409353	117/613 (19%)
		Ig strand C	51..55	CDD:409353	1/3 (33%)
		Ig strand C'	60..62	CDD:409353	0/1 (0%)
		Ig strand D	70..74	CDD:409353	0/3 (0%)
		Ig strand E	76..80	CDD:409353	0/3 (0%)
		Ig strand F	89..97	CDD:409353	0/7 (0%)
		Ig2_IL1R-like	124..210	CDD:409415	20/104 (19%)
		Ig strand B	135..139	CDD:409415	0/3 (0%)
		Ig strand C	150..154	CDD:409415	0/3 (0%)
		Ig strand E	170..174	CDD:409415	1/3 (33%)
		Ig strand F	184..189	CDD:409415	1/4 (25%)
		Ig strand G	201..204	CDD:409415	0/2 (0%)
		Flexible linker. /evidence=ECO:0000250	204..216		2/11 (18%)
		Ig	<291..324	CDD:416386	4/32 (13%)
		Ig strand E	291..294	CDD:409353	0/2 (0%)
		Ig strand F	305..310	CDD:409353	1/4 (25%)
		Ig strand G	318..321	CDD:409353	0/2 (0%)
		TIR	385..540	CDD:396246	36/159 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910