DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and Tlr8

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_573475.2 Gene:Tlr8 / 170744 MGIID:2176887 Length:1032 Species:Mus musculus


Alignment Length:1170 Identity:264/1170 - (22%)
Similarity:422/1170 - (36%) Gaps:378/1170 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 TSPVFHGWNIFKI--CNETDYELVIISVLGIRS--EVDMRISPAVQYLSLL--GIREISGYDIYL 190
            ||.:||..|..:.  |:|..:..::|:....|.  ||...|...|..:.|.  .|..|: .:.:.
Mouse    21 TSAIFHKANYSRSYPCDEIRHNSLVIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHIT-KESFQ 84

  Fly   191 PSVLITEMDVHH----------ANGPKM----------VTFKYLYDSTVN-------------SV 222
            ....:|::|::|          .||..:          :|...|.|:.:.             |:
Mouse    85 KLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSL 149

  Fly   223 ITNNYIRKTMNNT------EKIKIYYHNTFE-KTTLTME----KNIFHGKNKMSALIFNGLKIKG 276
            |.||..:.|.|||      |::.:.::..|: ..|..:|    ||:.|            ||:..
Mouse   150 IQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQTFKVEDGAFKNLIH------------LKVLS 202

  Fly   277 LTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVS 341
            |   :|.||                 |.....|.|||.            |.|  .:|.:|:.::
Mouse   203 L---SFNNL-----------------FYVPPKLPSSLR------------KLF--LSNAKIMNIT 233

  Fly   342 Q--YKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPV 404
            |  :||.:|.|.           ..|..|   || :|   ||               ...|..|.
Mouse   234 QEDFKGLENLTL-----------LDLSGN---CP-RC---YN---------------APFPCTPC 265

  Fly   405 PKKGSS----ALVFQS-------NL----LAELPDNSLEGYHNLKSLDVSYNQL-----TSLSVS 449
             |:.||    .|.|||       ||    |..:|....|...|||.|.:.:|.|     :...::
Mouse   266 -KENSSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLT 329

  Fly   450 QLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTS 514
            :|| ||..||:..|.      |..|||..:|:.:.:....|:  .:.||:.:.:.:     :|..
Mouse   330 KLP-SLQILDLSFNF------QYKEYLQFINISSNFSKLRSL--KKLHLRGYVFRE-----LKKK 380

  Fly   515 KFQTIMEYIELSSKG---SFVE--------NFFVQNIDQLYLEANE-DEIIDAFGPSDKYFNLKL 567
            .|:.:.....|::..   :|:|        ||  ..:|.:||..|. ..::|  |.....:..:|
Mouse   381 HFEHLQSLPNLATINLGINFIEKIDFKAFQNF--SKLDVIYLSGNRIASVLD--GTDYSSWRNRL 441

  Fly   568 MEALNHAIWLFSGEFD-EIILHHLNSPC--PYRCSCC------------------FEWHTGEFLI 611
            .:.|:    ....||| .:..:|...|.  | :|:..                  ||   |...|
Mouse   442 RKPLS----TDDDEFDPHVNFYHSTKPLIKP-QCTAYGKALDLSLNNIFIIGKSQFE---GFQDI 498

  Fly   612 NCRNLSLDIYPRLPN-----SIPYKTTLYL--------DRNEIRKLTNTESLVVAGHA---SI-- 658
            .|.|||.:...::.|     |:|:...|.|        |.|....|.:.|.|.::.:|   ||  
Mouse   499 ACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAG 563

  Fly   659 --HKLHMSQNL--LRELPL-----HLLPE------------------------------------ 678
              |:|...|||  ||.|.|     :.|.|                                    
Mouse   564 VTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIFKS 628

  Fly   679 --NITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETV 741
              |:..||:..|.|:.:.:|  |||...:::.::.:|||      |.:.|...|.::.|.     
Mouse   629 LQNLIRLDLSYNNLQQIPNG--AFLNLPQSLQELLISGN------KLRFFNWTLLQYFPH----- 680

  Fly   742 LRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWP 806
                                       .:::|.|..||..:|                |.|.|:.
Mouse   681 ---------------------------LHLLDLSRNELYFLP----------------NCLSKFA 702

  Fly   807 SSLLPGYSSVTRFYLAHNRLSDIDQLPD-------KLEYLDISNNNFSALDDRVRGFLQKRMNSS 864
            .||       ....|:||..|   .||.       .|.:||:|.|....::   :..||.:|.::
Mouse   703 HSL-------ETLLLSHNHFS---HLPSGFLSEARNLVHLDLSFNTIKMIN---KSSLQTKMKTN 754

  Fly   865 QLQLSLFGNPWTCRCEDKDFLVFVKEQAK-NIANASAIQCIDTG----RSLIEVEET----DICP 920
            ...|.|.||.:.|.|:..||..::.|... .|.....:.|.:.|    :|::.::.|    |...
Mouse   755 LSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPGDQKSKSIMSLDLTTCVSDTTA 819

  Fly   921 SVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKK-YDAFLSFTHK 984
            :||.:.|.|..|::::|..::....:.    :||..|.....|...|.....:. |||::|:..|
Mouse   820 AVLFFLTFLTTSMVMLAALVHHLFYWD----VWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTK 880

  Fly   985 DED----LIEEFVDRLENGRHK-FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKST 1044
            |..    :|.|....||....| ..||...|||..|..|.|.:.||:..|::.|.::||.:.||.
Mouse   881 DASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSW 945

  Fly  1045 WGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLD-RNNPN----FWNKL 1104
            ..:..|.|||.....:....:|.:|...|..:... ..||..:..::.|. .|||.    ||..|
Mouse   946 NFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQY-LRLRQRICKSSILQWPNNPKAENLFWQSL 1009

  Fly  1105  1104
            Mouse  1010  1009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..308 CDD:275380 1/19 (5%)
leucine-rich repeat 309..334 CDD:275380 6/24 (25%)
leucine-rich repeat 335..386 CDD:275380 13/52 (25%)
leucine-rich repeat 388..408 CDD:275380 3/19 (16%)
LRR_8 412..465 CDD:290566 22/68 (32%)
leucine-rich repeat 412..432 CDD:275378 9/30 (30%)
LRR_4 432..470 CDD:289563 13/42 (31%)
leucine-rich repeat 433..454 CDD:275378 7/25 (28%)
leucine-rich repeat 455..478 CDD:275378 8/22 (36%)
leucine-rich repeat 479..490 CDD:275378 1/10 (10%)
leucine-rich repeat 632..657 CDD:275378 8/35 (23%)
leucine-rich repeat 658..679 CDD:275378 12/69 (17%)
leucine-rich repeat 680..706 CDD:275378 8/25 (32%)
leucine-rich repeat 707..719 CDD:275378 3/11 (27%)
leucine-rich repeat 771..791 CDD:275380 5/19 (26%)
leucine-rich repeat 793..815 CDD:275378 5/21 (24%)
leucine-rich repeat 816..835 CDD:275378 6/25 (24%)
leucine-rich repeat 836..859 CDD:275378 6/22 (27%)
TIR 974..1110 CDD:214587 43/142 (30%)
Tlr8NP_573475.2 LRR_RI 32..252 CDD:238064 56/280 (20%)
LRR 1 41..61 4/19 (21%)
LRR 2 62..85 4/23 (17%)
LRR_8 65..133 CDD:290566 12/68 (18%)
leucine-rich repeat 65..88 CDD:275380 4/23 (17%)
LRR 3 87..109 3/21 (14%)
leucine-rich repeat 89..122 CDD:275380 5/32 (16%)
LRR 4 120..143 3/22 (14%)
leucine-rich repeat 123..143 CDD:275380 3/19 (16%)
leucine-rich repeat 144..167 CDD:275380 8/22 (36%)
LRR 5 145..165 8/19 (42%)
LRR_8 166..251 CDD:290566 28/141 (20%)
LRR 6 166..194 4/27 (15%)
leucine-rich repeat 168..197 CDD:275380 6/28 (21%)
LRR 7 195..218 9/54 (17%)
leucine-rich repeat 198..218 CDD:275380 8/39 (21%)
leucine-rich repeat 219..242 CDD:275380 8/36 (22%)
LRR 8 220..239 5/32 (16%)
LRR 9 240..267 11/60 (18%)
leucine-rich repeat 243..283 CDD:275380 17/73 (23%)
LRR_RI <277..>428 CDD:238064 40/166 (24%)
LRR 10 281..304 4/22 (18%)
LRR_8 282..342 CDD:290566 17/60 (28%)
leucine-rich repeat 284..307 CDD:275380 5/22 (23%)
LRR 11 306..329 6/22 (27%)
leucine-rich repeat 308..327 CDD:275380 5/18 (28%)
LRR 12 331..360 12/35 (34%)
leucine-rich repeat 334..363 CDD:275380 9/34 (26%)
LRR 13 361..384 5/29 (17%)
LRR_8 362..425 CDD:290566 14/71 (20%)
leucine-rich repeat 364..390 CDD:275380 4/32 (13%)
LRR 14 388..411 3/22 (14%)
leucine-rich repeat 391..414 CDD:275380 5/24 (21%)
LRR 15 413..436 6/24 (25%)
leucine-rich repeat 465..497 CDD:275380 5/35 (14%)
LRR 16 471..494 2/25 (8%)
LRR_8 475..533 CDD:290566 13/60 (22%)
leucine-rich repeat 501..522 CDD:275380 5/20 (25%)
LRR 17 520..543 5/22 (23%)
LRR_8 521..587 CDD:290566 20/65 (31%)
leucine-rich repeat 523..546 CDD:275380 5/22 (23%)
LRR 18 545..572 7/26 (27%)
LRR_RI 546..765 CDD:238064 60/287 (21%)
leucine-rich repeat 547..576 CDD:275380 10/28 (36%)
LRR 19 574..598 7/23 (30%)
leucine-rich repeat 577..600 CDD:275380 6/22 (27%)
LRR_8 600..667 CDD:290566 12/74 (16%)
LRR 20 600..621 0/20 (0%)
leucine-rich repeat 601..631 CDD:275380 0/29 (0%)
LRR 21 629..652 8/24 (33%)
leucine-rich repeat 632..656 CDD:275380 8/25 (32%)
LRR 22 654..677 6/28 (21%)
leucine-rich repeat 657..680 CDD:275380 6/28 (21%)
LRR 23 678..701 8/70 (11%)
LRR_8 679..737 CDD:290566 21/115 (18%)
leucine-rich repeat 681..704 CDD:275380 8/38 (21%)
LRR 24 702..725 8/32 (25%)
leucine-rich repeat 705..728 CDD:275380 7/32 (22%)
LRR 25 727..749 6/24 (25%)
leucine-rich repeat 729..748 CDD:275380 5/21 (24%)
LRR 26 752..776 8/23 (35%)
TIR 871..1007 CDD:214587 41/136 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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