DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-4 and Tlr7

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001277687.1 Gene:Tlr7 / 170743 MGIID:2176882 Length:1053 Species:Mus musculus


Alignment Length:1240 Identity:235/1240 - (18%)
Similarity:450/1240 - (36%) Gaps:425/1240 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 SHQKSKSNNDARNLNSRVRVRARVRVVPG-------------EMRMGDINCSNGLGNIREDYCEI 95
            :|..|.|.:..|.||....:..|...||.             ::|.|..   :||.:::    .:
Mouse    78 NHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSF---SGLSDLK----AL 135

  Fly    96 YLDELGENGTCSIANNEV--TTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVIISVL 158
            |||           .|::  ..:|....|..|.||.|         |||.|..|...|||.|..|
Mouse   136 YLD-----------GNQLLEIPQDLPSSLHLLSLEAN---------NIFSITKENLTELVNIETL 180

  Fly   159 GIRSEVDMR----ISPAVQ---YLSLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYD 216
            .:......|    :|.:::   :|.:..::.:|..|..:.:|..|.        |..:...|||:
Mouse   181 YLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTL--------PPNLLELYLYN 237

  Fly   217 STVNSVITNNYIRKTMNNTEKIKIY---------YHNTF------EKTTLTMEKNIFHGKNKMSA 266
            :.:..:..|::     ||..::::.         |:..:      ..:.|.:..|.|:...::..
Mouse   238 NIIKKIQENDF-----NNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKV 297

  Fly   267 LIFNGLKIKGLTNNTFENLTSLNTLIFDNVFL-------KDLSFLRSST-LQSSLTYCIMKVDNM 323
            |..:...::.:....|:|:.:|..|.....:|       |.|.||.:.. |..|..|.:......
Mouse   298 LRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHAS 362

  Fly   324 VDL-KSFEKFTNLEIIEVSQY--KGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKS 385
            :.| .|.....||:|:.|..|  |..||                                    |
Mouse   363 ITLPHSLSSLENLKILRVKGYVFKELKN------------------------------------S 391

  Fly   386 QLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVS- 449
            .|.:      |..:|.|.|...|::.:     .:|:|  |..:.:.|||.:|:|.|:::....| 
Mouse   392 SLSV------LHKLPRLEVLDLGTNFI-----KIADL--NIFKHFENLKLIDLSVNKISPSEESR 443

  Fly   450 -----------------QLPESLHY---------------------------------LDIRHNK 464
                             |:.|:|||                                 ||:..|.
Mouse   444 EVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNN 508

  Fly   465 ITTLSPQVVEYLYSVNVFNQYGNK----------WSI----YCDEYHLQEFFWYKAKLLRIKTSK 515
            |..:.|...::|..:...|..||.          |.:    |.|        :...:|..:.::.
Mouse   509 IFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLD--------FSNNRLDLLYSTA 565

  Fly   516 FQTI--MEYIELSSKGSFVE--------NFF--VQNIDQLYLEANEDEIIDAFGPSDKYFNLKLM 568
            |:.:  :|.::|||...:.:        ||.  ::.:|:|.:  |:::|..:...:.:..:|:::
Mouse   566 FEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMM--NDNDISTSASRTMESDSLRIL 628

  Fly   569 EALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTT 633
            |        |.|...:::                 |..|:      |..||.:..|.|       
Mouse   629 E--------FRGNHLDVL-----------------WRAGD------NRYLDFFKNLFN------- 655

  Fly   634 LYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL---LPENITYLDVRNNLLKYLDD 695
                                    :..|.:|:|.|..||..:   :|.|:..|.:..|.||    
Mouse   656 ------------------------LEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLK---- 692

  Fly   696 GVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCV 760
               :|.               |:       .|..|:..|                          
Mouse   693 ---SFF---------------WD-------RLQLLKHLE-------------------------- 706

  Fly   761 DTSNSDSLAYVVDCSGKELSEIPQ-LPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHN 824
                      ::|.|..:|:::|: |...:...|||:.:.|.:::           :|:::|.  
Mouse   707 ----------ILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQ-----------LTKYFLE-- 748

  Fly   825 RLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVK 889
                 |.|  :|.|||||:|....:  :...|.:..:|:.:: |.|..|.:.|.|:...|:.:|.
Mouse   749 -----DAL--QLRYLDISSNKIQVI--QKTSFPENVLNNLEM-LVLHHNRFLCNCDAVWFVWWVN 803

  Fly   890 EQAKNIAN-ASAIQCI----DTGRSLIEVE----ETDICPSVLIYYTSLAVSLLIIALSINVFIC 945
            .....|.. |:.:.|:    ..|:|:|.::    |.|: .:::::..|::..|.::.:.....:.
Mouse   804 HTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDL-TNLILFSVSISSVLFLMVVMTTSHLF 867

  Fly   946 FRQPIMIWF--------YEH----EICLSLAARRELDEDKKYDAFLSFTHKD----EDLIEEFVD 994
            |.....|::        |:|    |.|              ||||:.:..|:    |.:::|.|.
Mouse   868 FWDMWYIYYFWKAKIKGYQHLQSMESC--------------YDAFIVYDTKNSAVTEWVLQELVA 918

  Fly   995 RLENGRHK-FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATS 1058
            :||:.|.| |.||...||||.|:.:.:.::||::.|::.:.:||:.:.|:...::.|.|: |...
Mouse   919 KLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLS-HQRL 982

  Fly  1059 RDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLD-----RNNPNFWNKLMYSMPHASHLKRSR 1118
            .|....:|::::.:.........:||..:..::.|:     :.:|.||..|..::...:|:..|:
Mouse   983 LDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQ 1047

  Fly  1119 SDAET 1123
            ...||
Mouse  1048 MFKET 1052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 3/22 (14%)
leucine-rich repeat 288..308 CDD:275380 7/26 (27%)
leucine-rich repeat 309..334 CDD:275380 5/25 (20%)
leucine-rich repeat 335..386 CDD:275380 7/52 (13%)
leucine-rich repeat 388..408 CDD:275380 4/19 (21%)
LRR_8 412..465 CDD:290566 18/103 (17%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR_4 432..470 CDD:289563 16/88 (18%)
leucine-rich repeat 433..454 CDD:275378 7/38 (18%)
leucine-rich repeat 455..478 CDD:275378 9/55 (16%)
leucine-rich repeat 479..490 CDD:275378 3/20 (15%)
leucine-rich repeat 632..657 CDD:275378 0/24 (0%)
leucine-rich repeat 658..679 CDD:275378 7/23 (30%)
leucine-rich repeat 680..706 CDD:275378 5/25 (20%)
leucine-rich repeat 707..719 CDD:275378 1/11 (9%)
leucine-rich repeat 771..791 CDD:275380 5/20 (25%)
leucine-rich repeat 793..815 CDD:275378 4/21 (19%)
leucine-rich repeat 816..835 CDD:275378 4/18 (22%)
leucine-rich repeat 836..859 CDD:275378 8/22 (36%)
TIR 974..1110 CDD:214587 38/145 (26%)
Tlr7NP_001277687.1 PRK15370 <35..>246 CDD:185268 44/202 (22%)
leucine-rich repeat 51..72 CDD:275380
leucine-rich repeat 73..93 CDD:275380 5/14 (36%)
leucine-rich repeat 94..131 CDD:275380 7/39 (18%)
leucine-rich repeat 132..155 CDD:275380 6/37 (16%)
PLN00113 177..>789 CDD:215061 142/833 (17%)
leucine-rich repeat 177..208 CDD:275380 5/30 (17%)
leucine-rich repeat 209..229 CDD:275380 5/27 (19%)
leucine-rich repeat 230..253 CDD:275380 6/27 (22%)
leucine-rich repeat 254..294 CDD:275380 4/39 (10%)
leucine-rich repeat 295..318 CDD:275380 3/22 (14%)
leucine-rich repeat 319..344 CDD:275380 7/24 (29%)
leucine-rich repeat 345..401 CDD:275380 16/97 (16%)
leucine-rich repeat 402..425 CDD:275380 6/29 (21%)
leucine-rich repeat 500..522 CDD:275380 6/21 (29%)
leucine-rich repeat 523..547 CDD:275380 4/23 (17%)
leucine-rich repeat 548..571 CDD:275380 4/30 (13%)
leucine-rich repeat 572..601 CDD:275380 6/28 (21%)
leucine-rich repeat 602..624 CDD:275380 4/23 (17%)
leucine-rich repeat 625..655 CDD:275380 10/60 (17%)
leucine-rich repeat 656..680 CDD:275380 7/23 (30%)
leucine-rich repeat 681..704 CDD:275380 8/51 (16%)
leucine-rich repeat 705..728 CDD:275380 6/58 (10%)
leucine-rich repeat 753..778 CDD:275380 8/26 (31%)
PCC 757..>841 CDD:188093 20/86 (23%)
TIR 894..1039 CDD:214587 39/159 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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