DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and Tlr7

DIOPT Version :10

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001277687.1 Gene:Tlr7 / 170743 MGIID:2176882 Length:1053 Species:Mus musculus


Alignment Length:1240 Identity:235/1240 - (18%)
Similarity:450/1240 - (36%) Gaps:425/1240 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 SHQKSKSNNDARNLNSRVRVRARVRVVPG-------------EMRMGDINCSNGLGNIREDYCEI 95
            :|..|.|.:..|.||....:..|...||.             ::|.|..   :||.:::    .:
Mouse    78 NHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSF---SGLSDLK----AL 135

  Fly    96 YLDELGENGTCSIANNEV--TTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVIISVL 158
            |||           .|::  ..:|....|..|.||.|         |||.|..|...|||.|..|
Mouse   136 YLD-----------GNQLLEIPQDLPSSLHLLSLEAN---------NIFSITKENLTELVNIETL 180

  Fly   159 GIRSEVDMR----ISPAVQ---YLSLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYD 216
            .:......|    :|.:::   :|.:..::.:|..|..:.:|..|.        |..:...|||:
Mouse   181 YLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTL--------PPNLLELYLYN 237

  Fly   217 STVNSVITNNYIRKTMNNTEKIKIY---------YHNTF------EKTTLTMEKNIFHGKNKMSA 266
            :.:..:..|::     ||..::::.         |:..:      ..:.|.:..|.|:...::..
Mouse   238 NIIKKIQENDF-----NNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKV 297

  Fly   267 LIFNGLKIKGLTNNTFENLTSLNTLIFDNVFL-------KDLSFLRSST-LQSSLTYCIMKVDNM 323
            |..:...::.:....|:|:.:|..|.....:|       |.|.||.:.. |..|..|.:......
Mouse   298 LRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHAS 362

  Fly   324 VDL-KSFEKFTNLEIIEVSQY--KGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKS 385
            :.| .|.....||:|:.|..|  |..||                                    |
Mouse   363 ITLPHSLSSLENLKILRVKGYVFKELKN------------------------------------S 391

  Fly   386 QLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVS- 449
            .|.:      |..:|.|.|...|::.:     .:|:|  |..:.:.|||.:|:|.|:::....| 
Mouse   392 SLSV------LHKLPRLEVLDLGTNFI-----KIADL--NIFKHFENLKLIDLSVNKISPSEESR 443

  Fly   450 -----------------QLPESLHY---------------------------------LDIRHNK 464
                             |:.|:|||                                 ||:..|.
Mouse   444 EVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNN 508

  Fly   465 ITTLSPQVVEYLYSVNVFNQYGNK----------WSI----YCDEYHLQEFFWYKAKLLRIKTSK 515
            |..:.|...::|..:...|..||.          |.:    |.|        :...:|..:.::.
Mouse   509 IFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLD--------FSNNRLDLLYSTA 565

  Fly   516 FQTI--MEYIELSSKGSFVE--------NFF--VQNIDQLYLEANEDEIIDAFGPSDKYFNLKLM 568
            |:.:  :|.::|||...:.:        ||.  ::.:|:|.:  |:::|..:...:.:..:|:::
Mouse   566 FEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMM--NDNDISTSASRTMESDSLRIL 628

  Fly   569 EALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTT 633
            |        |.|...:::                 |..|:      |..||.:..|.|       
Mouse   629 E--------FRGNHLDVL-----------------WRAGD------NRYLDFFKNLFN------- 655

  Fly   634 LYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL---LPENITYLDVRNNLLKYLDD 695
                                    :..|.:|:|.|..||..:   :|.|:..|.:..|.||    
Mouse   656 ------------------------LEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLK---- 692

  Fly   696 GVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCV 760
               :|.               |:       .|..|:..|                          
Mouse   693 ---SFF---------------WD-------RLQLLKHLE-------------------------- 706

  Fly   761 DTSNSDSLAYVVDCSGKELSEIPQ-LPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHN 824
                      ::|.|..:|:::|: |...:...|||:.:.|.:::           :|:::|.  
Mouse   707 ----------ILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQ-----------LTKYFLE-- 748

  Fly   825 RLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVK 889
                 |.|  :|.|||||:|....:  :...|.:..:|:.:: |.|..|.:.|.|:...|:.:|.
Mouse   749 -----DAL--QLRYLDISSNKIQVI--QKTSFPENVLNNLEM-LVLHHNRFLCNCDAVWFVWWVN 803

  Fly   890 EQAKNIAN-ASAIQCI----DTGRSLIEVE----ETDICPSVLIYYTSLAVSLLIIALSINVFIC 945
            .....|.. |:.:.|:    ..|:|:|.::    |.|: .:::::..|::..|.::.:.....:.
Mouse   804 HTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDL-TNLILFSVSISSVLFLMVVMTTSHLF 867

  Fly   946 FRQPIMIWF--------YEH----EICLSLAARRELDEDKKYDAFLSFTHKD----EDLIEEFVD 994
            |.....|::        |:|    |.|              ||||:.:..|:    |.:::|.|.
Mouse   868 FWDMWYIYYFWKAKIKGYQHLQSMESC--------------YDAFIVYDTKNSAVTEWVLQELVA 918

  Fly   995 RLENGRHK-FRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATS 1058
            :||:.|.| |.||...||||.|:.:.:.::||::.|::.:.:||:.:.|:...::.|.|: |...
Mouse   919 KLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLS-HQRL 982

  Fly  1059 RDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLD-----RNNPNFWNKLMYSMPHASHLKRSR 1118
            .|....:|::::.:.........:||..:..::.|:     :.:|.||..|..::...:|:..|:
Mouse   983 LDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQ 1047

  Fly  1119 SDAET 1123
            ...||
Mouse  1048 MFKET 1052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 59/336 (18%)
leucine-rich repeat 264..287 CDD:275380 3/22 (14%)
leucine-rich repeat 288..308 CDD:275380 7/26 (27%)
leucine-rich repeat 309..334 CDD:275380 5/25 (20%)
leucine-rich repeat 335..386 CDD:275380 7/52 (13%)
PRK15370 <381..>482 CDD:185268 28/151 (19%)
leucine-rich repeat 388..408 CDD:275380 4/19 (21%)
leucine-rich repeat 412..432 CDD:275378 3/19 (16%)
LRR <416..591 CDD:443914 43/251 (17%)
leucine-rich repeat 433..454 CDD:275378 7/38 (18%)
leucine-rich repeat 455..478 CDD:275378 9/55 (16%)
leucine-rich repeat 479..490 CDD:275378 3/20 (15%)
leucine-rich repeat 632..657 CDD:275378 0/24 (0%)
leucine-rich repeat 658..679 CDD:275378 7/23 (30%)
leucine-rich repeat 680..706 CDD:275378 5/25 (20%)
PCC 684..>771 CDD:188093 8/86 (9%)
leucine-rich repeat 707..719 CDD:275378 1/11 (9%)
leucine-rich repeat 771..791 CDD:275380 5/20 (25%)
PRK15370 <793..>877 CDD:185268 20/83 (24%)
leucine-rich repeat 793..815 CDD:275378 4/21 (19%)
leucine-rich repeat 816..835 CDD:275378 4/18 (22%)
leucine-rich repeat 836..859 CDD:275378 8/22 (36%)
TIR 974..1110 CDD:214587 38/145 (26%)
Tlr7NP_001277687.1 PRK15370 <35..>246 CDD:185268 44/202 (22%)
leucine-rich repeat 51..72 CDD:275380
leucine-rich repeat 73..93 CDD:275380 5/14 (36%)
leucine-rich repeat 94..131 CDD:275380 7/39 (18%)
leucine-rich repeat 132..155 CDD:275380 6/37 (16%)
PLN00113 177..>789 CDD:215061 142/833 (17%)
leucine-rich repeat 177..208 CDD:275380 5/30 (17%)
leucine-rich repeat 209..229 CDD:275380 5/27 (19%)
leucine-rich repeat 230..253 CDD:275380 6/27 (22%)
leucine-rich repeat 254..294 CDD:275380 4/39 (10%)
leucine-rich repeat 295..318 CDD:275380 3/22 (14%)
leucine-rich repeat 319..344 CDD:275380 7/24 (29%)
leucine-rich repeat 345..401 CDD:275380 16/97 (16%)
leucine-rich repeat 402..425 CDD:275380 6/29 (21%)
LRR 487..>789 CDD:443914 77/461 (17%)
leucine-rich repeat 500..522 CDD:275380 6/21 (29%)
leucine-rich repeat 523..547 CDD:275380 4/23 (17%)
leucine-rich repeat 548..571 CDD:275380 4/30 (13%)
leucine-rich repeat 572..601 CDD:275380 6/28 (21%)
leucine-rich repeat 602..624 CDD:275380 4/23 (17%)
leucine-rich repeat 625..655 CDD:275380 10/60 (17%)
leucine-rich repeat 656..680 CDD:275380 7/23 (30%)
leucine-rich repeat 681..704 CDD:275380 8/51 (16%)
leucine-rich repeat 705..728 CDD:275380 6/58 (10%)
leucine-rich repeat 753..778 CDD:275380 8/26 (31%)
PCC 757..>841 CDD:188093 20/86 (23%)
TIR 894..1039 CDD:214587 39/159 (25%)
Blue background indicates that the domain is not in the aligned region.

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