DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Il1rap

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001152790.1	Gene:	Il1rap / 16180	MGIID:	104975	Length:	685	Species:	Mus musculus

Alignment Length:	690	Identity:	128/690 - (18%)
Similarity:	242/690 - (35%)	Gaps:	205/690 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 YLYSVNVFNQYGNKWSIYCDEYHL---QEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFF 536
            ||.|::.:....:..|..||::.|   ::...::.:..|||...|:..::|...::..|
Mouse     6 YLMSLSFYGILQSHASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSS------ 64

  Fly   537 VQNIDQLYLEANEDEIIDAFGPSDKYFNLKLME----ALNHAIWLFSGEFDEIILHHL-NSPCPY 596
              .:..::....:|..:      ::..|.:|.|    .....:|     |...:|:.. |..|..
Mouse    65 --GLTLIWYWTRQDRDL------EEPINFRLPENRISKEKDVLW-----FRPTLLNDTGNYTCML 116

  Fly   597 R----CS------------CCFE-----------WHTGEFLINCRNLSLDIYPRLPNSIPYKTTL 634
            |    ||            .||.           ...|...|.|.|  :|.|  .|:|:....|.
Mouse   117 RNTTYCSKVAFPLEVVQKDSCFNSAMRFPVHKMYIEHGIHKITCPN--VDGY--FPSSVKPSVTW 177

  Fly   635 YLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIA 699
            |....||....|.             |....||...:||           |.||      .....
Mouse   178 YKGCTEIVDFHNV-------------LPEGMNLSFFIPL-----------VSNN------GNYTC 212

  Fly   700 FLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSN 764
            .:.|.||.....|:                             |.|.:.....|:|.:.....|.
Mouse   213 VVTYPENGRLFHLT-----------------------------RTVTVKVVGSPKDALPPQIYSP 248

  Fly   765 SDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDI 829
            :|.:.|     .||..|...:|...|  .:.:.:.::...|                      .|
Mouse   249 NDRVVY-----EKEPGEELVIPCKVY--FSFIMDSHNEVWW----------------------TI 284

  Fly   830 D-QLPDKLEYLDISNN---NFSALDDRVRGFLQ--KRMNSSQLQLSLFGNPWTCRCEDKDFLVFV 888
            | :.||.:. :||:.|   ::|:.:|..|..:.  |::....|:.:     :.|...:      .
Mouse   285 DGKKPDDVT-VDITINESVSYSSTEDETRTQILSIKKVTPEDLRRN-----YVCHARN------T 337

  Fly   889 KEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIYYTSLA----VSLLIIALSINVFICFRQP 949
            |.:|:..|               :|::..|.|.   |...||    .::.::.:.|.|:..:...
Mouse   338 KGEAEQAA---------------KVKQKVIPPR---YTVELACGFGATVFLVVVLIVVYHVYWLE 384

  Fly   950 IMIWFYEHEICLSLAARRELDEDKKYDAFLSFTHKDEDLIEEFV-----DRLENGRHKFRLCFYL 1009
            :::::..|     ......:.:.|:||.::|:....|:  ||||     ..||| ...::||.:.
Mouse   385 MVLFYRAH-----FGTDETILDGKEYDIYVSYARNVEE--EEFVLLTLRGVLEN-EFGYKLCIFD 441

  Fly  1010 RDWLVGESIPDCINQSVKGSRRIIILMTKNFL-KSTWGRLEFRLALHATSRDRCKRLIVVLYPDV 1073
            ||.|.|.:..:.:...::.|||:|::::.::: :.:...|||:|.:...:....| ||||.|..:
Mouse   442 RDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIATK-LIVVEYRPL 505

  Fly  1074 EHFDDLDSELRAYMVLNTYLDRNNPN----FWNKLMYSMP 1109
            |.......:|:..:...::....:.:    ||..|..::|
Mouse   506 EQPHPGIMQLKESVSFVSWKGEKSKHSGSKFWKALRLALP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378	2/2 (100%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	5/24 (21%)
		leucine-rich repeat	658..679	CDD:275378	5/20 (25%)
		leucine-rich repeat	680..706	CDD:275378	4/25 (16%)
		leucine-rich repeat	707..719	CDD:275378	1/11 (9%)
		leucine-rich repeat	771..791	CDD:275380	4/19 (21%)
		leucine-rich repeat	793..815	CDD:275378	1/21 (5%)
		leucine-rich repeat	816..835	CDD:275378	3/19 (16%)
		leucine-rich repeat	836..859	CDD:275378	6/27 (22%)
		TIR	974..1110	CDD:214587	37/146 (25%)
Il1rap	NP_001152790.1	Ig1_IL1R_like	25..132	CDD:409584	20/125 (16%)
		Ig strand B	43..47	CDD:409584	2/3 (67%)
		Ig strand C	67..71	CDD:409584	0/3 (0%)
		Ig strand E	97..101	CDD:409584	1/8 (13%)
		Ig strand F	111..116	CDD:409584	2/4 (50%)
		Ig strand G	124..127	CDD:409584	0/2 (0%)
		Ig	145..235	CDD:416386	27/152 (18%)
		Ig strand A	145..150	CDD:409353	0/4 (0%)
		Ig strand A	145..150	CDD:409353	0/4 (0%)
		Ig strand B	156..160	CDD:409353	1/3 (33%)
		Ig strand B	156..160	CDD:409353	1/3 (33%)
		Ig strand C	174..179	CDD:409353	1/4 (25%)
		Ig strand C	174..179	CDD:409353	1/4 (25%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand D	189..193	CDD:409353	2/16 (13%)
		Ig strand D	189..193	CDD:409353	2/16 (13%)
		Ig strand E	195..200	CDD:409353	2/4 (50%)
		Ig strand E	195..200	CDD:409353	2/4 (50%)
		Ig strand F	209..218	CDD:409353	1/8 (13%)
		Ig strand F	209..218	CDD:409353	1/8 (13%)
		Ig strand G	221..234	CDD:409353	3/41 (7%)
		Ig strand G	221..234	CDD:409353	3/41 (7%)
		Ig3_IL1RAP	243..349	CDD:409525	26/161 (16%)
		Ig strand B	262..266	CDD:409525	0/3 (0%)
		Ig strand C	279..283	CDD:409525	1/25 (4%)
		Ig strand E	314..318	CDD:409525	0/3 (0%)
		Ig strand F	329..334	CDD:409525	1/9 (11%)
		Ig strand G	341..344	CDD:409525	1/2 (50%)
		TIR	404..547	CDD:214587	37/146 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910