DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and Il1r2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001347729.1	Gene:	Il1r2 / 16178	MGIID:	96546	Length:	428	Species:	Mus musculus

Alignment Length:	310	Identity:	57/310 - (18%)
Similarity:	94/310 - (30%)	Gaps:	125/310 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 QYKG--FKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNR-----------DKSQL----EI 389
            |::|  ||:......||.           .:.|||..:...:.           |.|||    |.
Mouse    61 QFRGREFKSELRLEGEPV-----------VLRCPLAPHSDISSSSHSFLTWSKLDSSQLIPRDEP 114

  Fly   390 DCWQK-NLTTIPSLPVPKKGSSALV--FQSNLLAELPDNSLEGYHNLKSL--DVSYNQLTSLSVS 449
            ..|.| |:..|  ||..::.|...:  |::....|.....|:.:.|.::.  .|||.|:::||.:
Mouse   115 RMWVKGNILWI--LPAVQQDSGTYICTFRNASHCEQMSVELKVFKNTEASLPHVSYLQISALSTT 177

  Fly   450 QLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTS 514
            .|               .:.|.:.|::.|    |..|             :..|||..:|
Mouse   178 GL---------------LVCPDLKEFISS----NADG-------------KIQWYKGAIL----- 205

  Fly   515 KFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFS 579
                                          |:....|.:.|..|:....:...|:...:
Mouse   206 ------------------------------LDKGNKEFLSAGDPTRLLISNTSMDDAGY------ 234

  Fly   580 GEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIP 629
                            |||...|.::..|:.|. ||:.|.:.......||
Mouse   235 ----------------YRCVMTFTYNGQEYNIT-RNIELRVKGTTTEPIP 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	10/56 (18%)
		leucine-rich repeat	388..408	CDD:275380	7/20 (35%)
		LRR_8	412..465	CDD:290566	11/56 (20%)
		leucine-rich repeat	412..432	CDD:275378	3/21 (14%)
		LRR_4	432..470	CDD:289563	8/39 (21%)
		leucine-rich repeat	433..454	CDD:275378	7/22 (32%)
		leucine-rich repeat	455..478	CDD:275378	2/22 (9%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
Il1r2	NP_001347729.1	PHA02785	54..382	CDD:165149	57/310 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910