DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Tlr3

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_001344245.1	Gene:	Tlr3 / 142980	MGIID:	2156367	Length:	905	Species:	Mus musculus

Alignment Length:	1051	Identity:	236/1051 - (22%)
Similarity:	408/1051 - (38%)	Gaps:	324/1051 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 ISVLGIRSEVDMRISPA--VQY--LSLL--GIREISGYDIYLPSV--LITEMDVHHANGPKMV-- 209
            |:||.:......|:.|.  .:|  |::|  |...||..:..|..:  |:..:::.| |....:
Mouse    54 ITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQH-NELSQISD 117

  Fly   210 -TFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLK 273
             ||.:..:.|...:::        |:..|||   .|.|:.     :||:.    |:. |..|||.
Mouse   118 QTFVFCTNLTELDLMS--------NSIHKIK---SNPFKN-----QKNLI----KLD-LSHNGLS 161

  Fly   274 IKGL-TNNTFENLTSLNTLIFDNVFL----KDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFT 333
            ...| |....|||..|  |:..|..|    ::|.||.:|:|:.            :||.|
Mouse   162 STKLGTGVQLENLQEL--LLAKNKILALRSEELEFLGNSSLRK------------LDLSS----- 207

  Fly   334 NLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTT 398
                      ...|.|:        ..|..|:|  ::...|..|...|...:  |..||:.:.|:
Mouse   208 ----------NPLKEFS--------PGCFQTIG--KLFALLLNNAQLNPHLT--EKLCWELSNTS 250

  Fly   399 IPSLPVPKKGSSALVFQSNLLAELPDNSLEG--YHNLKSLDVSYNQLTSL---SVSQLPESLHYL 458
            |.:|.:          .:|.|....:::..|  :.||..||:|||.|..:   |.|.|| ||.||
Mouse   251 IQNLSL----------ANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLP-SLRYL 304

  Fly   459 DIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYI 523
            .:.:|.|..|||:                              .:|....||..:.|.....:.:
Mouse   305 SLEYNNIQRLSPR------------------------------SFYGLSNLRYLSLKRAFTKQSV 339

  Fly   524 ELSSKGSFVENFFVQNIDQL-YLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIIL 587
            .|:|..: :::|..|.:..| ||..:::.|     ||.|                 |..|
Mouse   340 SLASHPN-IDDFSFQWLKYLEYLNMDDNNI-----PSTK-----------------SNTF----- 376

  Fly   588 HHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVV 652
                              ||  |::.:.|||.           ||.     ..::.||| |:.|.
Mouse   377 ------------------TG--LVSLKYLSLS-----------KTF-----TSLQTLTN-ETFVS 404

  Fly   653 AGHASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGV------IAFLEYR--ENITK 709
            ..|:.:..|::::|.:.::      .|.|:..:  ..|:.||.|:      ::..|:|  .||.:
Mouse   405 LAHSPLLTLNLTKNHISKI------ANGTFSWL--GQLRILDLGLNEIEQKLSGQEWRGLRNIFE 461

  Fly   710 IELSGNPW-ECNCKAKAFLSFLRRHEPMEYETVLRRVEITD-DKCPEDC-----ICCVDTSNSDS 767
            |.||.|.: :.:..:.|.:..|:|       .:||||.:.: |..|...     :..:|.|| ::
Mouse   462 IYLSYNKYLQLSTSSFALVPSLQR-------LMLRRVALKNVDISPSPFRPLRNLTILDLSN-NN 518

  Fly   768 LAYVVD--CSGKELSEIPQLPTPTYGQTTLVFERNSLKK-W-------PSSLLPGYSSVTRFYLA 822
            :|.:.:  ..|.|..||            |.|:.|:|.: |       |.:.|.|.|.:....|.
Mouse   519 IANINEDLLEGLENLEI------------LDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLE 571

  Fly   823 HNRLSDIDQLP-------DKLEYLDISNNNFSAL-----DDR--VRGF-LQKRMNSSQLQLSLFG 872
            .|.|   |::|       .:|:.:::..||.:.|     ||:  :|.. |||.:.:| ::..:||
Mouse   572 SNGL---DEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITS-VEKDVFG 632

  Fly   873 -------------NPWTCRCEDKDFLV-FVKEQAKNIANASAIQCIDTGRSL----IEVEETDIC 919
                         ||:.|.||...:.| ::.:...||:..|.....:|....    :::.:|..|
Mouse   633 PPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSSC 697

  Fly   920 ----PSVLIYY--TSLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELD---EDKKY 975
                |..|::.  ||:.:..:::.|.|::     :...|.||.:.....:...:|:|   |..:|
Mouse   698 KDSAPFELLFIISTSMLLVFILVVLLIHI-----EGWRISFYWNVSVHRILGFKEIDTQAEQFEY 757

  Fly   976 DAFLSFTHKDEDLIEEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNF 1040
            .|::...|||.|.:.|....:|......:.|...||:..|....:.|..|:|.||:||.::|.:.
Mouse   758 TAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHL 822

  Fly  1041 LKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRNNPNFWNKLM 1105
            ||....|   |..:|...:...::             :|||.:..::       :|.|:
Mouse   823 LKDPLCR---RFKVHHAVQQAIEQ-------------NLDSIILIFL-------QNIPD------ 858

  Fly  1106 YSMPHASHLKR 1116
            |.:.||..|:|
Mouse   859 YKLNHALCLRR 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	9/23 (39%)
		leucine-rich repeat	288..308	CDD:275380	7/23 (30%)
		leucine-rich repeat	309..334	CDD:275380	4/24 (17%)
		leucine-rich repeat	335..386	CDD:275380	8/50 (16%)
		leucine-rich repeat	388..408	CDD:275380	6/19 (32%)
		LRR_8	412..465	CDD:290566	20/57 (35%)
		leucine-rich repeat	412..432	CDD:275378	3/21 (14%)
		LRR_4	432..470	CDD:289563	19/40 (48%)
		leucine-rich repeat	433..454	CDD:275378	11/23 (48%)
		leucine-rich repeat	455..478	CDD:275378	8/22 (36%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	7/24 (29%)
		leucine-rich repeat	658..679	CDD:275378	2/20 (10%)
		leucine-rich repeat	680..706	CDD:275378	7/33 (21%)
		leucine-rich repeat	707..719	CDD:275378	5/12 (42%)
		leucine-rich repeat	771..791	CDD:275380	4/21 (19%)
		leucine-rich repeat	793..815	CDD:275378	8/29 (28%)
		leucine-rich repeat	816..835	CDD:275378	5/25 (20%)
		leucine-rich repeat	836..859	CDD:275378	8/30 (27%)
		TIR	974..1110	CDD:214587	31/135 (23%)
Tlr3	NP_001344245.1	leucine-rich repeat	37..53	CDD:275380
		LRR 1	53..74		5/19 (26%)
		leucine-rich repeat	54..77	CDD:275380	6/22 (27%)
		PLN00113	70..>543	CDD:215061	148/669 (22%)
		LRR 2	77..98		6/20 (30%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		LRR 3	101..122		5/21 (24%)
		leucine-rich repeat	102..125	CDD:275380	4/23 (17%)
		LRR 4	125..146		7/31 (23%)
		leucine-rich repeat	126..149	CDD:275380	7/38 (18%)
		LRR 5	149..170		8/25 (32%)
		leucine-rich repeat	150..199	CDD:275380	17/55 (31%)
		LRR 6	173..196		8/24 (33%)
		LRR 7	199..220		7/55 (13%)
		leucine-rich repeat	200..250	CDD:275380	15/88 (17%)
		LRR 8	250..271		4/30 (13%)
		leucine-rich repeat	251..276	CDD:275380	5/34 (15%)
		LRR 9	276..297		9/20 (45%)
		leucine-rich repeat	277..300	CDD:275380	11/23 (48%)
		LRR 10	300..321		9/50 (18%)
		leucine-rich repeat	301..324	CDD:275380	9/52 (17%)
		LRR 11	324..345		5/20 (25%)
		leucine-rich repeat	325..381	CDD:275380	19/103 (18%)
		LRR 12	357..378		9/65 (14%)
		LRR 13	381..401		8/36 (22%)
		leucine-rich repeat	382..433	CDD:275380	15/75 (20%)
		LRR 14	409..430		4/26 (15%)
		LRR 15	433..454		5/20 (25%)
		leucine-rich repeat	434..458	CDD:275380	6/23 (26%)
		LRR 16	458..479		6/20 (30%)
		leucine-rich repeat	459..482	CDD:275380	6/22 (27%)
		LRR 17	482..502		8/26 (31%)
		leucine-rich repeat	483..508	CDD:275380	8/31 (26%)
		PPP1R42	503..>649	CDD:411060	37/162 (23%)
		LRR 18	508..529		4/21 (19%)
		leucine-rich repeat	509..532	CDD:275380	5/23 (22%)
		LRR 19	532..553		7/32 (22%)
		leucine-rich repeat	533..564	CDD:275380	10/42 (24%)
		LRR 20	564..585		5/23 (22%)
		leucine-rich repeat	565..586	CDD:275380	5/23 (22%)
		LRR 21	588..609		4/20 (20%)
		leucine-rich repeat	589..610	CDD:275378	5/20 (25%)
		LRR 22	612..633		6/21 (29%)
		leucine-rich repeat	613..637	CDD:275380	7/24 (29%)
		LRRCT	646..698	CDD:214507	11/51 (22%)
		Tlr3_TMD	699..731	CDD:407816	6/36 (17%)
		TIR	756..901	CDD:214587	35/143 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920