DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and Fgfr1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_034336.2	Gene:	Fgfr1 / 14182	MGIID:	95522	Length:	822	Species:	Mus musculus

Alignment Length:	823	Identity:	165/823 - (20%)
Similarity:	265/823 - (32%)	Gaps:	271/823 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PEVRERRFKWTSDGQQQQQQQLGWC-NNKDDPPNSHQKSKSNNDARNLNSRVRVRA----RVRVV 70
            |..:..:||..|.|  .....|.|. |.|:..|          |.|....:||...    ...||
Mouse   169 PAAKTVKFKCPSSG--TPNPTLRWLKNGKEFKP----------DHRIGGYKVRYATWSIIMDSVV 221

  Fly    71 PGEMRMGDINC--SNGLGNIREDYCEIYLD-------------ELGENGTCSIANN-EVTTEDY- 118
            |.:  .|:..|  .|..|:|...|   .||             .|..|.|.::.:| |...:.|
Mouse   222 PSD--KGNYTCIVENEYGSINHTY---QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 281

  Fly   119 --QMKLVFLK-LEINWTS------PVFHGWNIFKIC--NETDYELVIISVLGIRSEVDMRISPAV 172
              |..:.:|| :|:|.:.      |..   .|.|..  |.||.|:.::.:..:..|      .|.
Mouse   282 DPQPHIQWLKHIEVNGSKIGPDNLPYV---QILKTAGVNTTDKEMEVLHLRNVSFE------DAG 337

  Fly   173 QYLSLLG--------------IREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSVI 223
            :|..|.|              :..:......:.|.|..|:.::       .|..:|....:.|||
Mouse   338 EYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIY-------CTGAFLISCMLGSVI 395

  Fly   224 TNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSL 288
                |.|..:.|                  :|:.||.:..:..|. ..:.::.....:.::..|:
Mouse   396 ----IYKMKSGT------------------KKSDFHSQMAVHKLA-KSIPLRRQVTVSADSSASM 437

  Fly   289 NTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFI 353
            |:.:.         .:|.|.|.||.|..:..|            :..|:.|..::: .......:
Mouse   438 NSGVL---------LVRPSRLSSSGTPMLAGV------------SEYELPEDPRWE-LPRDRLVL 480

  Fly   354 CEPYKSHCKFTLGINEVACPLKCNCSYNRDK---------SQLEIDCWQKNLTTIPSLPVPKKGS 409
            .:|....|...:.:.|.       ...::||         ..|:.|..:|:|
Mouse   481 GKPLGEGCFGQVVLAEA-------IGLDKDKPNRVTKVAVKMLKSDATEKDL------------- 525

  Fly   410 SALVFQSNLLAELPDNSLEGYH-NLKSLDVSYNQ-------LTSLSVSQLPESLHYLDIRHNKIT 466
                  |:|::|:....:.|.| |:.:|..:..|       :...|...|.|   ||..|.
Mouse   526 ------SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE---YLQARR---- 577

  Fly   467 TLSPQVVEYLY--SVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTI--MEYIELSS 527
               |..:||.|  |.|...|..:|..:.|                     .:|..  |||  |:|
Mouse   578 ---PPGLEYCYNPSHNPEEQLSSKDLVSC---------------------AYQVARGMEY--LAS 616

  Fly   528 KGSFVENFFVQNIDQLYLEANEDEIIDAFGPS------DKY-------FNLKLM--EALNHAIWL 577
            |.....:...:|:  |..|.|..:|.| ||.:      |.|       ..:|.|  |||
Mouse   617 KKCIHRDLAARNV--LVTEDNVMKIAD-FGLARDIHHIDYYKKTTNGRLPVKWMAPEAL------ 672

  Fly   578 FSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIR 642
                ||.|..|..:           .|..|..|.....|....||.:|....:|  |..:.:.:.
Mouse   673 ----FDRIYTHQSD-----------VWSFGVLLWEIFTLGGSPYPGVPVEELFK--LLKEGHRMD 720

  Fly   643 KLTN-TESLVVAGHASIHKLHMSQNLLRELPLHL-----LPENITYLDVRNNLLKYLDDGVIAFL 701
            |.:| |..|.:......|.:...:...::|...|     |..|..|||:...|.:|..    :|.
Mouse   721 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSP----SFP 781

  Fly   702 EYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRR 744
            :.|.:           .|:....:..|    |||:..|..|.|
Mouse   782 DTRSS-----------TCSSGEDSVFS----HEPLPEEPCLPR 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	1/22 (5%)
		leucine-rich repeat	288..308	CDD:275380	2/19 (11%)
		leucine-rich repeat	309..334	CDD:275380	5/24 (21%)
		leucine-rich repeat	335..386	CDD:275380	7/59 (12%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		LRR_8	412..465	CDD:290566	14/60 (23%)
		leucine-rich repeat	412..432	CDD:275378	5/20 (25%)
		LRR_4	432..470	CDD:289563	9/44 (20%)
		leucine-rich repeat	433..454	CDD:275378	4/27 (15%)
		leucine-rich repeat	455..478	CDD:275378	7/24 (29%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	5/25 (20%)
		leucine-rich repeat	658..679	CDD:275378	4/25 (16%)
		leucine-rich repeat	680..706	CDD:275378	7/25 (28%)
		leucine-rich repeat	707..719	CDD:275378	0/11 (0%)
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
Fgfr1	NP_034336.2	Ig1_FGFR	40..118	CDD:143174
		IG_like	41..118	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162
		I-set	160..247	CDD:254352	24/94 (26%)
		Heparin-binding	160..177		1/7 (14%)
		Ig2_FGFR	163..247	CDD:143265	24/94 (26%)
		IG_like	262..358	CDD:214653	22/104 (21%)
		Ig3_FGFR	270..359	CDD:143175	20/97 (21%)
		PTKc_FGFR1	464..765	CDD:270678	78/386 (20%)
		Pkinase_Tyr	478..754	CDD:285015	73/360 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	782..822		9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910