DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and Il1r2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_446405.1	Gene:	Il1r2 / 117022	RGDID:	621147	Length:	416	Species:	Rattus norvegicus

Alignment Length:	177	Identity:	37/177 - (20%)
Similarity:	64/177 - (36%)	Gaps:	42/177 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 DKSQL----EIDCWQKNLTTIPSLPVPKKGSSALV--FQSNLLAELPDNSLEGYHNLKSLD--VS 439
            |.|||    |...|.|: .|:..||..::.|...:  |::....|.....|:.:.|.::..  ||
  Rat    86 DSSQLIPGDEPRMWVKD-DTLWVLPAVQQDSGTYICTFRNASHCEQMSLELKVFKNTEASFPLVS 149

  Fly   440 YNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYL----------YSVNVFNQYGNK------ 488
            |.|:::||.:.|               .:.|.:.|::          |..::....|||
  Rat   150 YLQISALSSTGL---------------LVCPDLKEFISSRTDGKIQWYKGSILLDKGNKKFLSAG 199

  Fly   489 --WSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVE 533
              ..:......:.:..:|:..:......|...|...|||..||...|
  Rat   200 DPTRLLISNTSMGDAGYYRCVMTFTYEGKEYNITRNIELRVKGITTE 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	1/2 (50%)
		leucine-rich repeat	388..408	CDD:275380	6/19 (32%)
		LRR_8	412..465	CDD:290566	11/56 (20%)
		leucine-rich repeat	412..432	CDD:275378	3/21 (14%)
		LRR_4	432..470	CDD:289563	8/39 (21%)
		leucine-rich repeat	433..454	CDD:275378	7/22 (32%)
		leucine-rich repeat	455..478	CDD:275378	2/32 (6%)
		leucine-rich repeat	479..490	CDD:275378	3/18 (17%)
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
Il1r2	NP_446405.1	PHA02826	38..240	CDD:165173	34/169 (20%)
		Ig	44..137	CDD:299845	14/51 (27%)
		Ig	148..242	CDD:299845	19/108 (18%)
		I-set	249..343	CDD:254352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910