DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and IL1RAPL1

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	NP_055086.1	Gene:	IL1RAPL1 / 11141	HGNCID:	5996	Length:	696	Species:	Homo sapiens

Alignment Length:	423	Identity:	103/423 - (24%)
Similarity:	169/423 - (39%)	Gaps:	112/423 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   777 KELS--EIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEY- 838
            ||:|  :|.....||.....|.::....|.|..|::  :...| ..:...|..||.....:|:|
Human   160 KEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIV--FKRDT-LLIREVREDDIGNYTCELKYG 221

  Fly   839 ---------LDISNNNFSALDDRVRGFL---QKRMNSSQLQLSLFGNPWTCRC-----EDKDFLV 886
                     |.::    :.|.|:....|   :.::...:.||....| .|||.     .|...|:
Human   222 GFVVRRTTELTVT----APLTDKPPKLLYPMESKLTIQETQLGDSAN-LTCRAFFGYSGDVSPLI 281

  Fly   887 -------FVKEQAKNIANASAIQCI-------DTGRSLI--EVEETDI----C----------PS 921
                   |:::..:|....|.|:.:       :...|||  .|||.|:    |          .|
Human   282 YWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHAS 346

  Fly   922 VLIY-----YT-----SLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKK-Y 975
            ||::     ||     .|...||::...:.::.|::..||:::..|      ....|||.|.| |
Human   347 VLLHKRELMYTVELAGGLGAILLLLVCLVTIYKCYKIEIMLFYRNH------FGAEELDGDNKDY 405

  Fly   976 DAFLSFTHKDED------------LIEEFVDRLENGRHKFRLCFYLRDWL-VGESIPD---CINQ 1024
            ||:||:|..|.|            .:|...|.||. .:.::|....||.: .|..|.|   |::|
Human   406 DAYLSYTKVDPDQWNQETGEEERFALEILPDMLEK-HYGYKLFIPDRDLIPTGTYIEDVARCVDQ 469

  Fly  1025 SVKGSRRIIILMTKNF-LKSTWG--RLEFRLALHATSRD------RCKRLIVVL-YPDVEHFDDL 1079
                |:|:||:||.|: ::..|.  .||.||.....:.:      .|..|..:: |.:||   .|
Human   470 ----SKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVE---AL 527

  Fly  1080 DSELRAYMVLNTY---LDRNNPNFWNKLMYSMP 1109
            ...::...|:..:   .::.|..||.:|.|.||
Human   528 KHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMP 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378
		leucine-rich repeat	658..679	CDD:275378
		leucine-rich repeat	680..706	CDD:275378
		leucine-rich repeat	707..719	CDD:275378
		leucine-rich repeat	771..791	CDD:275380	6/15 (40%)
		leucine-rich repeat	793..815	CDD:275378	4/21 (19%)
		leucine-rich repeat	816..835	CDD:275378	4/18 (22%)
		leucine-rich repeat	836..859	CDD:275378	6/35 (17%)
		TIR	974..1110	CDD:214587	47/166 (28%)
IL1RAPL1	NP_055086.1	Ig1_IL1RAPL-1_like	32..135	CDD:143304
		Ig	148..239	CDD:386229	18/85 (21%)
		IGc2	260..341	CDD:197706	18/81 (22%)
		TIR	405..559	CDD:366714	44/161 (27%)
		Interaction with NCS1. /evidence=ECO:0000269\|PubMed:12783849	549..644		6/12 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910