DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and Il1rl2

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001343407.1 Gene:Il1rl2 / 107527 MGIID:1913107 Length:574 Species:Mus musculus


Alignment Length:658 Identity:115/658 - (17%)
Similarity:213/658 - (32%) Gaps:249/658 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   577 LFSGEF------------DEIILHHL----NSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLP 625
            ||.|.|            ::|.:|::    ..|.|:.|:                     ||...
Mouse     7 LFCGVFFLLLLFVAADTCEDIFMHNVIISEGQPFPFNCT---------------------YPPET 50

  Fly   626 NSIP----YKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHLLPENITYLDVR 686
            |...    |||.      ....::|...|         ::|..|..:..|||.|....|....:|
Mouse    51 NGAVNLTWYKTP------SKSPVSNNRHL---------RVHQDQTWILFLPLTLEDSGIYQCVIR 100

  Fly   687 NNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDK 751
            |....|         :...|:|.::   |.| |:...:.    ...:.|..|:.:|...:.....
Mouse   101 NAHNCY---------QIAVNLTVLK---NHW-CDSSMEG----SPVNSPDVYQQILPIGKSGSLN 148

  Fly   752 C----PEDCICCVDTSNSDSLAYVVDC----SGKELS---------------------------- 780
            |    ||.|..       ||:.:...|    :||:.|                            
Mouse   149 CHLYFPESCAL-------DSIKWYKGCEEIKAGKKYSPSGAKLLVNNVAVEDGGSYACSARLTHL 206

  Fly   781 ---------------EIP---QLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVT--------RF 819
                           |:.   ::|..||.      :.||::....|.|....::|        |.
Mouse   207 GRHFTIRNYIAVNTKEVEYGRRIPNITYP------KNNSIEVPLGSTLIVNCNITDTKENTNLRC 265

  Fly   820 YLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVR-----GFLQKRMNSSQLQLSLFGNPWTCRC 879
            :..:|.|.| |...|.....:....|.| |.|::|     .||:.:|..       :|.|:||. 
Mouse   266 WRVNNTLVD-DYYKDSKRIQEGIETNVS-LRDQIRYTVNITFLKVKMED-------YGRPFTCH- 320

  Fly   880 EDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVEETDICPSVLIY---------YTSLAVSLLI 935
                            |..||...|                  |||         ...|...||:
Mouse   321 ----------------AGVSAAYII------------------LIYPVPDFRAYLLGGLMAFLLL 351

  Fly   936 IALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSFT--------HKDEDLIEEF 992
            :...:.::..|:..||:|:..     :....:..|::|.|||::.:.        |..:.|:.:.
Mouse   352 VVSVLFIYNSFKIDIMLWYRS-----AFHTAQAPDDEKLYDAYVLYPKYPRGSQGHDVDTLVLKI 411

  Fly   993 VDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRL----EFRLA 1053
            :..:...:..::|..:.||...|:::...|::::|..||:::.:...  .|::|.|    |.::|
Mouse   412 LPEVLEKQCGYKLFIFGRDEFPGQAVASVIDENIKLCRRLMVFVAPE--SSSFGFLKNLSEEQIA 474

  Fly  1054 LHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRNN-----------------PNFW 1101
            ::........::|::....|:.:..:...::       |:.:.:                 ..||
Mouse   475 VYNALIQHGMKVILIELEKVKDYSTMPESIQ-------YIRQKHGAIQWDGDFTEQSQCAKTKFW 532

  Fly  1102 NKLMYSMP 1109
            .|:.|.||
Mouse   533 KKVRYHMP 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380
leucine-rich repeat 388..408 CDD:275380
LRR_8 412..465 CDD:290566
leucine-rich repeat 412..432 CDD:275378
LRR_4 432..470 CDD:289563
leucine-rich repeat 433..454 CDD:275378
leucine-rich repeat 455..478 CDD:275378
leucine-rich repeat 479..490 CDD:275378
leucine-rich repeat 632..657 CDD:275378 3/24 (13%)
leucine-rich repeat 658..679 CDD:275378 6/20 (30%)
leucine-rich repeat 680..706 CDD:275378 4/25 (16%)
leucine-rich repeat 707..719 CDD:275378 3/11 (27%)
leucine-rich repeat 771..791 CDD:275380 7/69 (10%)
leucine-rich repeat 793..815 CDD:275378 4/21 (19%)
leucine-rich repeat 816..835 CDD:275378 6/26 (23%)
leucine-rich repeat 836..859 CDD:275378 7/27 (26%)
TIR 974..1110 CDD:214587 27/165 (16%)
Il1rl2NP_001343407.1 Ig 25..115 CDD:416386 25/134 (19%)
Ig strand A' 31..35 CDD:409353 0/3 (0%)
Ig strand B 39..44 CDD:409353 2/4 (50%)
Ig strand C 55..59 CDD:409353 0/3 (0%)
Ig strand C' 64..66 CDD:409353 0/1 (0%)
Ig strand D 74..78 CDD:409353 1/3 (33%)
Ig strand E 80..84 CDD:409353 0/3 (0%)
Ig strand F 93..101 CDD:409353 1/7 (14%)
Ig strand G 104..115 CDD:409353 3/19 (16%)
Ig 135..222 CDD:416386 12/93 (13%)
Ig strand A 135..140 CDD:409353 1/4 (25%)
Ig strand B 145..149 CDD:409353 0/3 (0%)
Ig strand C 161..166 CDD:409353 1/4 (25%)
Ig strand C' 169..171 CDD:409353 0/1 (0%)
Ig strand D 176..180 CDD:409353 1/3 (33%)
Ig strand E 182..187 CDD:409353 0/4 (0%)
Ig strand F 196..205 CDD:409353 0/8 (0%)
Ig strand G 208..221 CDD:409353 0/12 (0%)
Ig 230..332 CDD:416386 31/151 (21%)
Ig strand A 230..233 CDD:409353 1/2 (50%)
Ig strand A' 238..241 CDD:409353 2/2 (100%)
Ig strand B 246..255 CDD:409353 2/8 (25%)
Ig strand C 262..268 CDD:409353 1/5 (20%)
Ig strand C' 270..273 CDD:409353 1/2 (50%)
Ig strand G 322..332 CDD:409353 4/27 (15%)
TIR 389..539 CDD:396246 22/158 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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