DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and LOC103911657

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_009303036.2	Gene:	LOC103911657 / 103911657	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	1002	Identity:	217/1002 - (21%)
Similarity:	358/1002 - (35%)	Gaps:	330/1002 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 TTLTMEKNIFHGKNK----------MSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSF 303
            |:||:..|.....:|          :::|..:...:..|.:|.||.:..|..||..||.|:|:|
Zfish   124 TSLTISYNFSENCSKVALDFSHLPSLTSLSISDYSLSLLASNVFETIPLLQNLILANVCLRDMS- 187

  Fly   304 LRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEII-EVSQYKGFKNFT--AFICEPYKSHCKFTL 365
                                            |:: .:|:.|..|:||  .|:
Zfish   188 --------------------------------EVLCRLSKVKTLKHFTLKEFL------------ 208

  Fly   366 GINEVACPLKCNCS-YNRDKSQLEIDCWQKNL--TTIP-----SLPVPKKGSSALVFQSNLLAEL 422
             :..:..|   ||| :|......|.:..:.||  .|:.     :|.|..| .|..||..:....|
Zfish   209 -LKRLQYP---NCSVFNTSDISTEFNIEEVNLHFATVEHVDEGALKVFGK-LSRFVFSVSSTDFL 268

  Fly   423 PDNSLEGYHNLKSLD--VSYNQLTSLSVSQLPESLHYLDIRHNKITTLSP--------------- 470
            .|.||.|.|.:|:||  |....:..|..:.....::.:.::: |.|...|
Zfish   269 RDLSLIGVHKIKTLDFKVDLLNVADLCTAAKLYGINSIQVKY-KTTNFWPTHTNISGGCKNIKDV 332

  Fly   471 QVVEYLYSVN------VFNQYGNKW--SIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSS 527
            .:...||..|      ||..:.|..  |||.......:|....|..  .:|.|..:.|: :.|..
Zfish   333 MLDTILYPANLLDVNCVFQIFSNLTIISIYKHVLRSDDFQTLCASF--PQTVKHLSAMD-LRLKK 394

  Fly   528 KGSFVENFFV--QNIDQLYLEANEDEIIDAFGPSDKYFNLKLMEALN-----------HAIWLFS 579
            ..:.|.:.|:  .|::.|...:::..:|:.|.    :..|..::.||           |.   ||
Zfish   395 VDTIVSHQFMCFPNLETLIFTSSKIVVIEDFA----FIGLNKLKELNLRKNKISSIHRHT---FS 452

  Fly   580 GEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKL 644
            |      ||.|                         |.||:.   .|.|     :|::.......
Zfish   453 G------LHEL-------------------------LVLDLQ---ENPI-----IYIEPKSFGHF 478

  Fly   645 TNTESLVVAG-----HASIHKLHMS-------QNL--------LRELPLHLLPENITYLDVRNNL 689
            ||..||::..     :.|:.|||:|       .||        ||  |:||:..:.|.|   ||.
Zfish   479 TNLSSLLLGDLNFPPNMSLIKLHLSDIFGGIPSNLSNVFISSGLR--PMHLMIGSNTTL---NNG 538

  Fly   690 LKYLDDGVIAFLE-----YRENITKIELSGNPWECNCKAKAFLSFLRRHEP----MEYETVLRRV 745
            |.....|....:|     ...::.|:::......|.      ..|:.::.|    :|::::.
Zfish   539 LNLHIKGQYVIVEDCNSLLLTSVVKLQIHAAYMSCE------NDFIGKYVPSVVSLEFQSMF--- 594

  Fly   746 EITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLL 810
                               ||::.        :||.|.||    :...||..........|::.:
Zfish   595 -------------------SDNIG--------DLSVINQL----FHLKTLKLRNIEFTNQPNTGI 628

  Fly   811 PGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNS-SQLQLS----- 869
                      :.||.        .|||.|.:||.....||    |.|.|.:.: ::|.||
Zfish   629 ----------MFHNL--------TKLETLILSNCRIFFLD----GSLTKDLKALTKLLLSAKHTV 671

  Fly   870 ----------------------LFGNPWTCRCEDKDFLVFVKEQAK---NIANASA--IQC---- 903
                                  |:     |.|::.....:||:..|   .::|.|.  :||
Zfish   672 NILQSFVEHLVHLEYIHIDSIDLY-----CSCDNAWLFSWVKDNRKVEVVVSNPSMQNLQCFIGN 731

  Fly   904 -IDTGRSLIEVEETDICPSVLIYYTSLAVSL---LIIALSINVFICFRQPIMI----WFYEHEIC 960
             .|....:..|:|..:.....:.:||.:|.|   :::.|..|....:.:|...    ||.|
Zfish   732 EFDQLNFVSYVKENCLFDLDFVLFTSTSVFLCIFIVVVLMYNFVGQYLKPFYHIANGWFRE---- 792

  Fly   961 LSLAARRELDEDKKYDAFLSFTHKDED-LIEEFVDRLE-NGRHKFRLCFYLRDWLVGESIPDCIN 1023
               |.|.:..:..:||||:|::.|||. :|||.:..|| .|....|||.:.||:.:|..|.:.|.
Zfish   793 ---ALRMKEKQQYRYDAFVSYSGKDEHWVIEELLPNLEQRGPPFLRLCLHSRDFQLGHDIVENIT 854

  Fly  1024 QSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDV------EHFDDLDSE 1082
            .|:..|||.:.|:::|:|.|.|..||.:||.:....:....||:|....:      .|     ..
Zfish   855 DSIYASRRTLCLVSRNYLNSNWCSLEMQLATYRLQVEHRDILILVFLETIPSCLLSSH-----HR 914

  Fly  1083 LRAYMVLNTYLD-----RNNPNFWNKL 1104
            |...:...||||     ..:..||::|
Zfish   915 LARLVKTRTYLDCPQEPEMHDAFWDRL 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..308	CDD:275380	8/19 (42%)
		leucine-rich repeat	309..334	CDD:275380	0/24 (0%)
		leucine-rich repeat	335..386	CDD:275380	12/54 (22%)
		leucine-rich repeat	388..408	CDD:275380	6/26 (23%)
		LRR_8	412..465	CDD:290566	13/54 (24%)
		leucine-rich repeat	412..432	CDD:275378	7/19 (37%)
		LRR_4	432..470	CDD:289563	7/39 (18%)
		leucine-rich repeat	433..454	CDD:275378	5/22 (23%)
		leucine-rich repeat	455..478	CDD:275378	4/37 (11%)
		leucine-rich repeat	479..490	CDD:275378	4/18 (22%)
		leucine-rich repeat	632..657	CDD:275378	5/29 (17%)
		leucine-rich repeat	658..679	CDD:275378	11/35 (31%)
		leucine-rich repeat	680..706	CDD:275378	7/30 (23%)
		leucine-rich repeat	707..719	CDD:275378	1/11 (9%)
		leucine-rich repeat	771..791	CDD:275380	5/19 (26%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	2/18 (11%)
		leucine-rich repeat	836..859	CDD:275378	9/22 (41%)
		TIR	974..1110	CDD:214587	47/144 (33%)
LOC103911657	XP_009303036.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920