DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and TLR6

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:NP_001381482.1 Gene:TLR6 / 10333 HGNCID:16711 Length:796 Species:Homo sapiens


Alignment Length:874 Identity:172/874 - (19%)
Similarity:313/874 - (35%) Gaps:291/874 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   383 DKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYN--QLT 444
            |.::..:|..::.|..:| .||:..|   .|....|.:|||..:.:.....|..|.:|:|  ||.
Human    30 DGNEFAVDKSKRGLIHVPKDLPLKTK---VLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLL 91

  Fly   445 SLSVSQLPESLHYLDIRHNKITTLS-PQVVEYLY---SVNVF------NQYGNKWSI-------- 491
            .|||.:..:.|.|||:.||::..:| ..:|.:.:   |.|.|      .::||...:        
Human    92 DLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAM 156

  Fly   492 -------------------------YCDEYHLQEFFWYKAKLLRI---KTSKF------------ 516
                                     |..|...:......||.|.:   .||.|            
Human   157 KLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLG 221

  Fly   517 --------------QTIMEYIELSSKGSFVENFFVQNIDQL-----------------YLEANED 550
                          |..::::...::||.:.||.:.:|:..                 ||.....
Human   222 CLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNL 286

  Fly   551 EIIDAFGPSDKYFNLKLMEAL-----NHAIWLFS--------GEFDEIILHHLNSP-----CPYR 597
            .||::....|..::...::||     .:.::|||        .|.:.::|...::|     ||:.
Human   287 TIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHA 351

  Fly   598 CSCCFEWHTGEFLINCRNLSLD-IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKL 661
            .|      |.:||...:|:..| |:.:....:..: ||.|.:|.::.|... .|:.....|:..|
Human   352 PS------TFKFLNFTQNVFTDSIFEKCSTLVKLE-TLILQKNGLKDLFKV-GLMTKDMPSLEIL 408

  Fly   662 HMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAF 726
            .:|.|.| |...|  .||.|::                     |:|..:.||.|           
Human   409 DVSWNSL-ESGRH--KENCTWV---------------------ESIVVLNLSSN----------- 438

  Fly   727 LSFLRRHEPMEYETVLR----RVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPT 787
                     |..::|.|    |::                        |:|....::..:|:...
Human   439 ---------MLTDSVFRCLPPRIK------------------------VLDLHSNKIKSVPKQVV 470

  Fly   788 PTYGQTTLVFERNSLKKWPSSLLPG---YSSVTRFYLAHNRLS----DIDQLPDKLEYLDISNNN 845
            .......|....|||..     |||   :||::...:.||.:|    |..|...|:..:...:  
Human   471 KLEALQELNVAFNSLTD-----LPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGD-- 528

  Fly   846 FSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANAS---------AI 901
                                       ||:.|.||.::|:       |||...|         :.
Human   529 ---------------------------NPFQCTCELREFV-------KNIDQVSSEVLEGWPDSY 559

  Fly   902 QCID-----TGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICL 961
            :| |     .|..|.:...:::..::.:...::..::|::|:::.....:..  :.| |...:|.
Human   560 KC-DYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLD--LPW-YLRMVCQ 620

  Fly   962 SLAARR--------ELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYLRDWLVGES 1017
            ....||        ||..:.::.||:|::..|...:: |.|..||  :...::|.:.|:::.|:|
Human   621 WTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLE--KEDIQICLHERNFVPGKS 683

  Fly  1018 IPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVL--------YPDVE 1074
            |.:.|...::.|.:.|.:::.||::|.|...|...|.|....:....||::|        .|:..
Human   684 IVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKY 748

  Fly  1075 HFDDLDSELRAYMVLNTYLDRNNPNFWNK 1103
            |      :|:|.|...|||.      |.|
Human   749 H------KLKALMTQRTYLQ------WPK 765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 1/2 (50%)
leucine-rich repeat 388..408 CDD:275380 5/20 (25%)
LRR_8 412..465 CDD:290566 20/54 (37%)
leucine-rich repeat 412..432 CDD:275378 5/19 (26%)
LRR_4 432..470 CDD:289563 16/40 (40%)
leucine-rich repeat 433..454 CDD:275378 9/22 (41%)
leucine-rich repeat 455..478 CDD:275378 8/26 (31%)
leucine-rich repeat 479..490 CDD:275378 4/16 (25%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 6/20 (30%)
leucine-rich repeat 680..706 CDD:275378 1/25 (4%)
leucine-rich repeat 707..719 CDD:275378 4/11 (36%)
leucine-rich repeat 771..791 CDD:275380 3/19 (16%)
leucine-rich repeat 793..815 CDD:275378 7/24 (29%)
leucine-rich repeat 816..835 CDD:275378 5/22 (23%)
leucine-rich repeat 836..859 CDD:275378 0/22 (0%)
TIR 974..1110 CDD:214587 36/139 (26%)
TLR6NP_001381482.1 LRR 1 54..77 6/25 (24%)
LRR 2 78..101 9/22 (41%)
LRR 3 102..122 7/19 (37%)
LRR 4 123..147 5/23 (22%)
LRR 5 148..168 0/19 (0%)
LRR 6 169..196 2/26 (8%)
LRR 7 197..219 5/21 (24%)
LRR 8 220..250 2/29 (7%)
LRR 9 251..277 3/25 (12%)
LRR 10 278..303 5/24 (21%)
LRR 11 304..330 5/25 (20%)
LRR 12 331..354 5/28 (18%)
LRR 13 355..378 5/22 (23%)
LRR 14 379..404 6/26 (23%)
LRR 15 405..429 9/47 (19%)
LRR 16 430..450 7/39 (18%)
LRR 17 451..474 4/46 (9%)
LRR 18 475..496 7/25 (28%)
LRR 19 497..520 5/22 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 1 1.000 - - FOG0000239
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.920

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