Protein Alignment Toll-4 and cd180

DIOPT Version :9

• Sequence 1: NP_523519.2
• Gene: Toll-4 / 34235
• FlyBaseID: FBgn0032095
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001297419.1
• Gene: cd180 / 101885327
• ZFINID: ZDB-GENE-070705-323
• Length: 665
• Species: Danio rerio
• Alignment Length: 679
• Identity: 145/679 - (21%)
• Similarity: 244/679 - (35%)
• Gaps: 183/679 - (26%)

  Fly   390 DCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLT---------- 444
            ||...:|.:||. .:| .....|.|..|.|..|.:::.:...:|:||||:...:|
Zfish    40 DCNDMDLQSIPD-EIP-NSVQILQFSFNYLPALYNSTFQRLKSLRSLDVTRCSITFIYEDVFTYQ 102

  Fly   445 -SLSVSQL---------------PESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYG-NKWSIY 492
             .|.|..|               |.:|.||.:..:||..||....|.|..:.|.:..| |..|:
Zfish   103 PHLEVLLLTGNPLVFIASTAFSGPLALKYLSLVQSKIKQLSDIPSENLAYLEVLDLRGSNIRSL- 166

  Fly   493 CDEYHLQEFFWYKAKLLRIKTS-----KFQTIMEY-----IELSSKGS---FVE--NFFVQNIDQ 542
               ..|..|.|...|.|::..:     .|..:..:     :.:|.||:   ::|  .|...|:..
Zfish   167 ---NGLSNFRWQNLKSLQLDLNFIDRISFNDLQPFSNLAGVSISFKGNDFIYIEPGAFHSLNLSS 228

  Fly   543 LYL-----EANEDEIIDAF-GPSDKYFNLKLME----------ALNHAIWLFSGEFDEIILHHL- 590
            |..     :.|...::... |......||.|.|          ||.....:|..:.|..:.|.|
Zfish   229 LDFSGCLNKMNISSLLKGLEGIKTNRLNLGLYETDSNVYIASAALQSFCNIFVSDLDFQLQHFLD 293

  Fly   591 --NSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTT-------LYLDRNEIRKL-- 644
              ||          .:|..|.|     ..||:.....|::|..||       |.||.|:.:.:
Zfish   294 LNNS----------TFHCLEGL-----KKLDLTRAHLNALPLNTTGLSTLSHLILDENQFKDVCQ 343

  Fly   645 TNTESLVVAGHASI----HKLHMSQ------NLLRELPLHLLPENITYLDVR----NNLLKYLDD 695
            :||.:..:..|.||    .||..|.      .||.||.|     :::.::.|    ||.|..|.:
Zfish   344 SNTRNFPMLTHLSISGNLKKLTFSNRCLDSLGLLEELDL-----SVSLVNPREPCCNNQLFGLGE 403

  Fly   696 GVIAFLEYRENITKIELSGNP--WECNCKAKAFLSFLRRHEPMEYE----TVLRRVEITDDKCPE 754
            ..:..|.|          |:|  |    .:|.| :...:.|.:::.    |:|      :|..|.
Zfish   404 LKLLNLSY----------GSPMFW----SSKPF-NVTPKLEHLDFSHSVYTLL------NDSSPF 447

  Fly   755 DCICCVDT-----SNSDSLAYVVDCSGKELSEIPQLPTPTYGQT--------------TLVFERN 800
            ..:..:.|     ||:|.....:....|.|..:........|:.              |||....
Zfish   448 SNLQSLRTLNLSWSNTDLTNVHLFVGLKALQHLNLRGNAIQGEVLTQTELFKCVPLLETLVLSAC 512

  Fly   801 SLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQ 865
            .:..:..:|..|...:....|:.|:            ::.:|.:.|.:||.....|.:..:.:..
Zfish   513 KITSFDENLFKGLRHLNHIDLSENK------------FVKLSTSGFYSLDFLKLNFARNDITTVD 565

  Fly   866 L----------QLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVE-ETDIC 919
            :          .:.|..||..|.|.:.:|:.:||:....:.:.....|..||..:|:.: :.|:.
Zfish   566 VASVADLGEEGSVDLSYNPLVCNCSNFEFIHWVKKNKVKVKHLMETFCNGTGTRIIDAKLQCDLP 630

  Fly   920 PSVLIYYTSLAVSLLIIALSINVFICFRQ 948
            ..||::...||..||..|    :|:..|:
Zfish   631 VGVLVFCAVLAAVLLASA----IFLLIRR 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380	6/17 (35%)
		LRR_8	412..465	CDD:290566	18/78 (23%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	16/63 (25%)
		leucine-rich repeat	433..454	CDD:275378	10/46 (22%)
		leucine-rich repeat	455..478	CDD:275378	9/22 (41%)
		leucine-rich repeat	479..490	CDD:275378	3/11 (27%)
		leucine-rich repeat	632..657	CDD:275378	9/33 (27%)
		leucine-rich repeat	658..679	CDD:275378	9/30 (30%)
		leucine-rich repeat	680..706	CDD:275378	7/29 (24%)
		leucine-rich repeat	707..719	CDD:275378	3/13 (23%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	5/35 (14%)
		leucine-rich repeat	816..835	CDD:275378	2/18 (11%)
		leucine-rich repeat	836..859	CDD:275378	5/22 (23%)
		TIR	974..1110	CDD:214587
cd180	NP_001297419.1	leucine-rich repeat	40..56	CDD:275380	6/17 (35%)
		LRR_8	56..115	CDD:316378	14/58 (24%)
		leucine-rich repeat	57..80	CDD:275380	5/22 (23%)
		leucine-rich repeat	81..104	CDD:275380	6/22 (27%)
		LRR_8	103..163	CDD:316378	15/59 (25%)
		leucine-rich repeat	105..128	CDD:275380	4/22 (18%)
		leucine-rich repeat	153..176	CDD:275380	7/26 (27%)
		leucine-rich repeat	177..200	CDD:275380	3/22 (14%)
		leucine-rich repeat	201..225	CDD:275380	5/23 (22%)
		leucine-rich repeat	226..247	CDD:275380	2/20 (10%)
		leucine-rich repeat	284..304	CDD:275378	6/29 (21%)
		leucine-rich repeat	305..327	CDD:275380	7/26 (27%)
		leucine-rich repeat	328..351	CDD:275380	6/22 (27%)
		leucine-rich repeat	352..376	CDD:275380	6/23 (26%)
		leucine-rich repeat	404..427	CDD:275380	7/37 (19%)
		LRR_8	426..487	CDD:316378	11/66 (17%)
		leucine-rich repeat	428..452	CDD:275380	5/29 (17%)
		leucine-rich repeat	453..476	CDD:275380	4/22 (18%)
		leucine-rich repeat	477..503	CDD:275380	2/25 (8%)
		LRR_8	502..561	CDD:316378	12/70 (17%)
		leucine-rich repeat	504..527	CDD:275380	5/22 (23%)
		leucine-rich repeat	528..549	CDD:275380	4/32 (13%)
		leucine-rich repeat	552..574	CDD:275380	1/21 (5%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910