DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and LOC100496647

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_002940742.3	Gene:	LOC100496647 / 100496647	-ID:	-	Length:	879	Species:	Xenopus tropicalis

Alignment Length:	974	Identity:	212/974 - (21%)
Similarity:	364/974 - (37%)	Gaps:	245/974 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 SALIFNGLKIKGLTNNT----FENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVD 325
            |||.|..:.....||..    :.|||.:..:..|.:.| ||||...|.:.|:.   ..::..:||
Frog    24 SALAFGQIPKCTTTNRIAYFFYCNLTHMPPVNSDTLVL-DLSFNYLSEVNSTF---FPRLLQLVD 84

  Fly   326 LKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEID 390
            |....:.|...|::..   .|:|..:.:                     |.:.:||:
Frog    85 LNLGSQQTERLIVKKD---SFRNTPSLV---------------------KLDLAYNQ-------- 117

  Fly   391 CWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTS--LSVSQLPE 453
                                        |..|..:.|.|...||.|.:.||:|..  |......:
Frog   118 ----------------------------LLILDSDGLAGLSQLKILFLYYNKLNGSILENDYFKD 154

  Fly   454 --SLHYLDIRHNKITTLSPQVVEY-LYSVNVFNQYGNKWSIYC--DEYHLQEFFWYKAKLLRIKT 513
              ||.|:|:..|:||.|.|..:.| |||:::.|...|:.|..|  |.:..:..::...:|...:.
Frog   155 LMSLEYVDLSSNEITYLRPNPLFYHLYSLDIINLRHNQISSICAGDLHSFERKYFTIMELSHNRF 219

  Fly   514 SKFQTI-----------MEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKL 567
            :|::|:           :|:..|...|:   .|.|..:.:.....|          ..|...|||
Frog   220 NKWETLGSDRCGNPFRNIEFDTLMLSGT---GFDVDKMQKFCGALN----------GTKMMQLKL 271

  Fly   568 MEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLD-----IYPRLPNS 627
            .   :|.:....|      .:|:..|         :..|...|:|.....||     |:...|.:
Frog   272 D---SHGMGAGFG------YNHIKDP---------DNSTFVGLVNSNLQILDLSTGNIFSLKPYT 318

  Fly   628 IPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLREL---PLHLLP------------ 677
            ....|.|.|......|:...|:....|..|:..|::|.|||.||   ....||
Frog   319 FGNLTVLKLLNLAENKINRIENKAFCGLNSLITLNLSYNLLGELYDYSFEGLPDLTTIDLQQNHI 383

  Fly   678 -----------ENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLR 731
                       |.:.|||:|.|.:|     .:.|.|....||.|...||..:....:..:.:||.
Frog   384 GAIQNNAFKSLEKLNYLDLRGNAMK-----KVTFFEALIPITYIFFGGNKLKSIDSSYVYSTFLD 443

  Fly   732 RHE---------------PMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSE 781
            ..|               |:....:|:|..::      .|......|.::||.: :|.|...::.
Frog   444 LSENDLNDLGGLFKILQYPLLQYVILKRNRLS------VCYSHFSISKNNSLLH-LDLSDNMINL 501

  Fly   782 IPQLPTPTYGQTTLVF-----------ERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDI--DQLP 833
            |..     .||...||           ..|.|:..|..:..|..|:....|:.|.|:.:  ...|
Frog   502 IWD-----NGQCLNVFSNLSLLGLLKLNNNFLRYLPEGIFNGLESLQTLNLSSNLLTHLMPGVFP 561

  Fly   834 DKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANA 898
            ..|:.:|:|.|...:...:|  ||      |..:|.|..|.:.|.|...||::::.|     .||
Frog   562 TNLDTVDLSKNQLYSPSPKV--FL------SVKKLDLTHNQYICDCFLLDFIMWLNE-----TNA 613

  Fly   899 SAI------QCIDTGRSLIE------VEETD----ICPSVLIYYTSLAVSLLIIALSINVFICFR 947
            :.:      .|:.....|.:      ||..|    :.|.:...:...:.::|::..::..:..:|
Frog   614 TLLGSPYDTYCMYPPNFLFQPLHILTVENCDDDKVLMPLMFSLFVLTSTTILVLMSTVVTYTHYR 678

  Fly   948 QPIMIWFYEHEICLSLAARRELDEDK----KYDAFLSFTHKDEDLIEE-FVDRLEN---GRHKFR 1004
            .   ..|..::..|.|....|..|:.    ||||:|.::.||...::: |:..|:.   .|::||
Frog   679 G---FCFATYKRILGLIIGNEKKEEAADACKYDAYLCYSSKDFQWVQDAFLRNLDTQYCDRNRFR 740

  Fly  1005 LCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTW--GRLEFRLALHATS-RDRCKRLI 1066
            |||..||::.||.....|..::..|::.|.::||.|||..|  ..|.:..:.:.|. :|   .||
Frog   741 LCFEERDFIPGEDHIVNIRDAIWNSKKTICIVTKQFLKDGWCVEALNYAQSRYFTELKD---VLI 802

  Fly  1067 VVLYPDVEHFDDLDSE-LRAYMVLNTYL----DRNNPN-FWNKLMYSMPHASHLKRSRSDAETK 1124
            :|:...:..:..:..: :|||:....||    |..:.. |..:|.|.:...:.:::..:.|..|
Frog   803 MVVVGSLSQYQFMKYQPIRAYVKRAQYLRWPEDIQDVEWFLGRLSYQILKENTVEKKPNQASRK 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/25 (32%)
		leucine-rich repeat	288..308	CDD:275380	6/19 (32%)
		leucine-rich repeat	309..334	CDD:275380	4/24 (17%)
		leucine-rich repeat	335..386	CDD:275380	6/50 (12%)
		leucine-rich repeat	388..408	CDD:275380	0/19 (0%)
		LRR_8	412..465	CDD:290566	16/56 (29%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	15/41 (37%)
		leucine-rich repeat	433..454	CDD:275378	7/24 (29%)
		leucine-rich repeat	455..478	CDD:275378	10/23 (43%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	6/24 (25%)
		leucine-rich repeat	658..679	CDD:275378	9/46 (20%)
		leucine-rich repeat	680..706	CDD:275378	8/25 (32%)
		leucine-rich repeat	707..719	CDD:275378	5/11 (45%)
		leucine-rich repeat	771..791	CDD:275380	3/19 (16%)
		leucine-rich repeat	793..815	CDD:275378	6/32 (19%)
		leucine-rich repeat	816..835	CDD:275378	4/20 (20%)
		leucine-rich repeat	836..859	CDD:275378	7/22 (32%)
		TIR	974..1110	CDD:214587	43/148 (29%)
LOC100496647	XP_002940742.3	leucine-rich repeat	158..182	CDD:275380	10/23 (43%)
		leucine-rich repeat	183..260	CDD:275380	13/79 (16%)
		leucine-rich repeat	261..300	CDD:275380	12/66 (18%)
		LRR_8	299..359	CDD:404697	14/59 (24%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		leucine-rich repeat	373..396	CDD:275380	0/22 (0%)
		leucine-rich repeat	419..446	CDD:275380	7/26 (27%)
		leucine-rich repeat	464..488	CDD:275380	4/29 (14%)
		leucine-rich repeat	489..541	CDD:275380	12/57 (21%)
		leucine-rich repeat	542..563	CDD:275380	4/20 (20%)
		leucine-rich repeat	564..582	CDD:275380	5/19 (26%)
		TIR	706..841	CDD:214587	40/137 (29%)
		leucine-rich repeat	60..81	CDD:275380	7/24 (29%)
		leucine-rich repeat	82..107	CDD:275380	7/27 (26%)
		LRR_8	106..168	CDD:404697	19/118 (16%)
		leucine-rich repeat	108..131	CDD:275380	7/79 (9%)
		leucine-rich repeat	132..157	CDD:275380	7/24 (29%)
		PLN00113	158..>594	CDD:215061	107/491 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010