DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr8

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_002933859.2	Gene:	tlr8 / 100496108	XenbaseID:	XB-GENE-485083	Length:	1037	Species:	Xenopus tropicalis

Alignment Length:	1057	Identity:	249/1057 - (23%)
Similarity:	412/1057 - (38%)	Gaps:	252/1057 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 KMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIY-YHNTFEKTTLTMEKNIFHGKNKM--SALI 268
            |||.....|:|....::.:..:..|:||.   ..| :||.   |.:.:..| .:.|:::  :.|.
Frog    52 KMVPHPITYNSDSAELLLSQNLILTINNE---SFYSWHNL---TKIDLNWN-HYPKSRLNNTDLC 109

  Fly   269 FNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQS-SLTY----------------- 315
            ..||:|   .|.||..||.|..|..|:.||..:.....||:|: ||:|
Frog   110 KRGLEI---GNETFSYLTKLEELFIDHNFLCKIPQGIPSTVQTLSLSYNNIFSVKKQILSPLINL 171

  Fly   316 --------CIM--KVDNMVDLK--SFEKFTNLEIIEVSQYKGFKNFT-------AFICEPYKSHC 361
                    |..  :.|::||::  :|...|.|.::::|    |.|.|       |.:.|.|.|:.
Frog   172 KKLFLNHNCYFGNECDHVVDIEEGTFAGLTELTVLDLS----FNNMTRVPAKLPASLKELYLSNN 232

  Fly   362 KFTL--------GIN-EVA-----CPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSAL 412
            ...:        .|| ||.     ||...|.:|     ..:..|.|.::|..|......|..:.|
Frog   233 NIQIIHSDDLQNLINLEVLFLNGNCPRCFNANY-----PCKNLCKQISITIDPLAFQNLKNLTEL 292

  Fly   413 VFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVS-----QLPESLHYLDIRHNKITTLSPQV 472
            ...|..|..:|....:....||.|::..|.|.:...|     .|| .|..||:..|.      .:
Frog   293 HLGSTSLRTIPPIWFQNTTQLKILNLQLNYLVNEIASADFLLNLP-FLEVLDLSFNY------DL 350

  Fly   473 VEYLYSVNVFNQYGNKWSIYCDEYHLQEFFW--YKAKLLR--IKTSKFQTIMEYIELSSKGSFVE 533
            ..|..::|:.|.:....|:  .|.|:|.:.:  ..||.|.  |...|..||...|....:..| |
Frog   351 RSYANNINISNHFSKLISL--QELHIQGYVFKHIAAKNLSPLINLPKLATINLGINFIKQVDF-E 412

  Fly   534 NFFVQNIDQL---YLEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSG-----------EFDE 584
            .|  |||..|   ||..|.   |..|..::|    :|........:..|.           :..:
Frog   413 VF--QNISGLKLIYLSENR---ITPFSETNK----QLFGVCKDQSYRISSPGVTFPTQSNFQMTK 468

  Fly   585 IILHHLNSPCPYR-------CSCCFEWHTGEFL----INCRNLSLDIYPRLPNSIPY---KTTLY 635
            |..|.:...|..|       .:..|.....||.    ::|.|||.:...:..|...:   |...|
Frog   469 IFSHLVKPQCSSRGKTLDLSLNSIFFIDPEEFRSFSDVSCLNLSFNSIGQDLNGTEFIYLKNLTY 533

  Fly   636 LDRNEIRKLTNTESLVVAGHASIHKLHM-SQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIA 699
            ||                  .|.:||.. |.|..:|||      ::..||:..|...::.|||..
Frog   534 LD------------------LSFNKLDFDSINAFQELP------SLEVLDLSYNSHYFIVDGVTH 574

  Fly   700 FLEYRENITKIELSGNPWECNCKAKAFLSF-LRRHEPMEYETVLRRVEI---TDDKCPEDC---- 756
            .|::.||:..:::....|.   |......| |..|...|.:....|:::   .:||..::.
Frog   575 RLKFIENLQYLKVLNLSWN---KISTLTDFRLTSHSLKELQFSGNRLDVLWKNEDKRYQELFKNL 636

  Fly   757 --ICCVDTSNS--DSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLPGYSSVT 817
              :.|:|.|.:  :.:..|      |||.:|      ...|.|....|.|..:....|..|.::.
Frog   637 YNLTCLDISYNRLNKMTEV------ELSNLP------LSLTELYLNNNKLDYFGWKALKAYKNLK 689

  Fly   818 RFYLAHNRLS----DIDQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLS--------- 869
            ...|:||:|:    ::......|..|.||.|:.|:|.   ..||.|..|.|:|.||
Frog   690 HLDLSHNKLTMIMGNLSIHTYSLSSLIISYNSISSLP---VAFLHKSRNLSELDLSFNHLKSINS 751

  Fly   870 ---------------LFGNPWTCRCEDKDFLVFVKEQAKNIA---NASAIQCI------DTGRSL 910
                           |.|||:.|.||..||:.::  .|.|:.   .|:.:.|.      .:|...
Frog   752 SVFLSGSENYLTVLGLKGNPFVCTCEITDFISWI--YANNVTIPRLATDVNCAAPENKKGSGIIF 814

  Fly   911 IEVEETDICPSVLIYY---TSLAVSLLIIALSINVFICFRQPIMIW--FYEHEICLSLAARRELD 970
            .:|...|:..:.:|.|   ..|.:|:.::.:.||||        .|  :|.:.:|::.....::.
Frog   815 FDVHTCDLDGAAMILYFFSVFLVMSITVLPILINVF--------SWDLWYVYHLCVAKLRWHKVC 871

  Fly   971 EDK-KYDAFLSFTHKDED----LIEEFVDRLEN--GRHKFRLCFYLRDWLVGESIPDCINQSVKG 1028
            :.| .||.|:::.:||.:    :..|....||:  .:|.: ||...|||..|::|.|.:..|:..
Frog   872 KSKCLYDVFITYDNKDPNVSDWIFNELCQHLEDKGDKHMY-LCLEERDWEPGKAIIDNLAHSINQ 935

  Fly  1029 SRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLY-PDVEHFDDLDSELRAYMVLNTY 1092
            |.:.:.::||.::||...:..|.|||.....:....:::||. |.:::...|  .||..:..::.
Frog   936 SNKTLFVLTKKYVKSGKFKTAFYLALQKLMDENMDVIVIVLLEPVLQNSQYL--RLRRKICKSSI 998

  Fly  1093 LD-RNNPN----FWNKL 1104
            :: ..|||    ||.::
Frog   999 MEWPKNPNTKSFFWQRM 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/24 (33%)
		leucine-rich repeat	288..308	CDD:275380	5/19 (26%)
		leucine-rich repeat	309..334	CDD:275380	9/54 (17%)
		leucine-rich repeat	335..386	CDD:275380	17/71 (24%)
		leucine-rich repeat	388..408	CDD:275380	4/19 (21%)
		LRR_8	412..465	CDD:290566	16/57 (28%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	12/42 (29%)
		leucine-rich repeat	433..454	CDD:275378	8/25 (32%)
		leucine-rich repeat	455..478	CDD:275378	5/22 (23%)
		leucine-rich repeat	479..490	CDD:275378	2/10 (20%)
		leucine-rich repeat	632..657	CDD:275378	3/24 (13%)
		leucine-rich repeat	658..679	CDD:275378	7/21 (33%)
		leucine-rich repeat	680..706	CDD:275378	7/25 (28%)
		leucine-rich repeat	707..719	CDD:275378	1/11 (9%)
		leucine-rich repeat	771..791	CDD:275380	5/19 (26%)
		leucine-rich repeat	793..815	CDD:275378	6/21 (29%)
		leucine-rich repeat	816..835	CDD:275378	4/22 (18%)
		leucine-rich repeat	836..859	CDD:275378	9/22 (41%)
		TIR	974..1110	CDD:214587	38/143 (27%)
tlr8	XP_002933859.2	leucine-rich repeat	45..64	CDD:275380	5/11 (45%)
		leucine-rich repeat	66..87	CDD:275380	4/23 (17%)
		leucine-rich repeat	88..125	CDD:275380	11/43 (26%)
		leucine-rich repeat	126..145	CDD:275380	5/18 (28%)
		PLN00113	132..>563	CDD:215061	109/482 (23%)
		leucine-rich repeat	147..170	CDD:275380	4/22 (18%)
		leucine-rich repeat	171..202	CDD:275380	5/30 (17%)
		leucine-rich repeat	203..223	CDD:275380	5/23 (22%)
		leucine-rich repeat	224..247	CDD:275380	3/22 (14%)
		leucine-rich repeat	248..288	CDD:275380	10/44 (23%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		leucine-rich repeat	313..338	CDD:275380	8/25 (32%)
		leucine-rich repeat	339..368	CDD:275380	7/34 (21%)
		leucine-rich repeat	400..419	CDD:275380	7/21 (33%)
		leucine-rich repeat	483..505	CDD:275380	3/21 (14%)
		leucine-rich repeat	509..530	CDD:275380	4/20 (20%)
		leucine-rich repeat	531..554	CDD:275380	11/46 (24%)
		leucine-rich repeat	555..584	CDD:275380	9/28 (32%)
		leucine-rich repeat	585..607	CDD:275380	4/24 (17%)
		PPP1R42	588..772	CDD:411060	45/201 (22%)
		leucine-rich repeat	608..638	CDD:275380	4/29 (14%)
		leucine-rich repeat	639..663	CDD:275380	8/35 (23%)
		leucine-rich repeat	664..687	CDD:275380	6/22 (27%)
		leucine-rich repeat	688..711	CDD:275380	4/22 (18%)
		leucine-rich repeat	712..735	CDD:275380	10/25 (40%)
		leucine-rich repeat	736..754	CDD:275380	4/17 (24%)
		TPKR_C2	770..>809	CDD:417692	11/40 (28%)
		TIR_2	877..1014	CDD:419986	38/139 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920