DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr9

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_017948709.2	Gene:	tlr9 / 100494387	XenbaseID:	XB-GENE-486908	Length:	1035	Species:	Xenopus tropicalis

Alignment Length:	1014	Identity:	211/1014 - (20%)
Similarity:	374/1014 - (36%)	Gaps:	340/1014 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 TTLTMEKNIFHGKN------KMSALIFNGLKIKGLTNNTFE---NLTSLNTLIFDNVFLKDLSFL 304
            |.:..|:.:.|..:      |:..|..|.:::  |.|:||.   ||..||  :.||        .
Frog    50 TVICRERQLIHVPHIVSQSVKVFDLAINEIRL--LANSTFSGVPNLVILN--LSDN--------C 102

  Fly   305 RSSTLQSSLTYC--IMKVDNMVDLKSFE-------------------KFTNLEIIEVSQYKGFK- 347
            :.|.|:.....|  |::...:|.|||..                   ||.||.:.::....|::
Frog   103 QPSNLRPYKEICRLIIEPHALVSLKSLTNLDLSGNSLTSIPPLPENIKFLNLNLNQIHMISGWEF 167

  Fly   348 -----------NFTAFI---CEPYKSHCKFTLGIN-----EVACPLKCNCSYNRDKSQLEIDCWQ 393
                       .:..|.   |||:  |...:..||     |:|      .|:|
Frog   168 SRLNNVKMIRLGYNCFYSKQCEPF--HLSDSAFINNEFLEELA------LSFN------------ 212

  Fly   394 KNLTTIP-SLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSY----------------N 441
             |:|:.| :||   .....|....|.::::....|...:||.|||:.:                |
Frog   213 -NITSFPQNLP---SSIRILDLSENKISKIDREDLCNLNNLHSLDLQWNCQRCDHALQACYPCKN 273

  Fly   442 QLTSLSVSQLPESLH---YLDIRHNKITTLSPQVVEYLYSVN---------------VFNQYGNK 488
            ....|.|..:.:.||   ||::|.|.:.||...:...|.:::               .|:...|.
Frog   274 NSALLLVPGVFDCLHKLSYLNLRGNSLHTLHSSLFSSLTNLSHLVLSDNFLNLETETFFSALTNV 338

  Fly   489 WSIYCD----EYHLQEFFWYKAKLLRIKTSKFQTIMEYI--ELSSKG-------------SFVEN 534
            ..:..|    .|.:.|.....:.:.|:|:.:..||:.|.  .|..:|             |...|
Frog   339 KELNLDFNFKPYSMYERLVLNSNVARMKSLERITIVGYFFNVLDEEGIMPLLSLPNLREISLRTN 403

  Fly   535 FFVQ-NIDQL-------YLEANEDEI-----------------------IDAFGPSDKYFNLKLM 568
            |.:: |:..|       ::..:|:.|                       :|. |..|.:...|.:
Frog   404 FILKVNLSMLFTHKPLRFISLSENLISFEEHKHGQKLAMHPPLFDRGNQVDG-GWMDSHCGPKQV 467

  Fly   569 EA----------LNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFL----INCRNLSLD 619
            ||          .||::        ::..:::.|..|           .|||    |.|.|:|.:
Frog   468 EAGEVEYPGCWQYNHSV--------DLSFNNIGSIYP-----------DEFLGMDEIECLNMSYN 513

  Fly   620 IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGH-ASIHKLHMSQN--------LLRELPLHL 675
                           |::    ::|..|:    .|| .|:..|.:|.|        .|.|||
Frog   514 ---------------YIN----QRLNGTQ----FGHLKSLRHLDLSHNRFDMYYYKALSELP--- 552

  Fly   676 LPENITYLDVRNNLLKYLDDGVIAFLEYRENITK-IELSGNPWECNCKAKAFLSF-----LRRHE 734
               .:..|::.:|..:::..||...|::.||:|. :||:.|        ..|:..     |:.|.
Frog   553 ---RLKILNLAHNDYQFMMKGVNHRLDFLENLTSLVELNLN--------NNFIGLRITRELKSHS 606

  Fly   735 PMEYETVLRRVEITDDKCPEDCICCVDT-----SNSDSLAYVVDCSGKELSEIP-----QLP--- 786
                   |..:...:::.........||     :|..||. ::|.|..:|..||     :||
Frog   607 -------LETLRFRNNELGSSWQYGKDTYLNMFTNLRSLK-ILDISYNQLPVIPNEVLEKLPESL 663

  Fly   787 -----------TPTYGQTT-------LVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLP 833
                       |..:.:|.       |....|:|.|..::|..  |::....|.:|:::.:|:
Frog   664 QKLNLSHNKLYTFNWAKTAHLGNLAILDLGFNALTKLRANLTE--SNIAFLNLTYNKINSLDK-- 724

  Fly   834 D------KLEYLDISNNNFSALDDRVRGF-LQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQ 891
            |      :|:.|.:|||....:  .:..| :....|...|.:|  |||:.|.|:...|:.|:.|.
Frog   725 DFFDSFSELKQLILSNNLIKTI--HITSFPINFLQNLDSLDVS--GNPFQCTCKAYWFITFLMET 785

  Fly   892 AKNIANASAIQCIDT-----GRSLIEVEETD-------ICPSVLIYYTSLAVSLLIIALSINVFI 944
            ...:.:.|.....|:     ||||:.::...       :|   .|:.:.|.:.|::|....|:|.
Frog   786 EVTVDHLSTGMKCDSPDSLRGRSLLSMDPQSCQELYGHVC---FIWSSILVIFLMVIPTIWNLFF 847

  Fly   945 CFRQPIMIWFYEHEICLSLAARRELDEDKK---YDAFLSFTHKDED----LIEEFVDRLEN-GRH 1001
            .     .:|:..|.|..:|.:..:| .||.   :|||::|..|:..    :..|.:.:||: .|.
Frog   848 W-----NLWYAGHLIVATLRSYTKL-HDKSTEHFDAFIAFNTKNSSVRDWVYNELLVQLESPERG 906

  Fly  1002 KFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNF 1040
            .|.||...|||:.|.|..:.:..|:..|::.|.::|:.:
Frog   907 GFTLCLEERDWIAGRSSIENLYDSIYRSKKTIFIITREW 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	8/25 (32%)
		leucine-rich repeat	288..308	CDD:275380	4/19 (21%)
		leucine-rich repeat	309..334	CDD:275380	9/45 (20%)
		leucine-rich repeat	335..386	CDD:275380	13/70 (19%)
		leucine-rich repeat	388..408	CDD:275380	5/20 (25%)
		LRR_8	412..465	CDD:290566	17/71 (24%)
		leucine-rich repeat	412..432	CDD:275378	3/19 (16%)
		LRR_4	432..470	CDD:289563	16/56 (29%)
		leucine-rich repeat	433..454	CDD:275378	7/36 (19%)
		leucine-rich repeat	455..478	CDD:275378	9/25 (36%)
		leucine-rich repeat	479..490	CDD:275378	2/25 (8%)
		leucine-rich repeat	632..657	CDD:275378	5/25 (20%)
		leucine-rich repeat	658..679	CDD:275378	7/28 (25%)
		leucine-rich repeat	680..706	CDD:275378	5/25 (20%)
		leucine-rich repeat	707..719	CDD:275378	4/12 (33%)
		leucine-rich repeat	771..791	CDD:275380	8/38 (21%)
		leucine-rich repeat	793..815	CDD:275378	6/28 (21%)
		leucine-rich repeat	816..835	CDD:275378	4/24 (17%)
		leucine-rich repeat	836..859	CDD:275378	6/23 (26%)
		TIR	974..1110	CDD:214587	21/75 (28%)
tlr9	XP_017948709.2	leucine-rich repeat	69..92	CDD:275380	7/24 (29%)
		PLN00113	82..>592	CDD:215061	119/600 (20%)
		leucine-rich repeat	93..128	CDD:275380	11/44 (25%)
		leucine-rich repeat	129..148	CDD:275380	0/18 (0%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..203	CDD:275380	7/31 (23%)
		leucine-rich repeat	204..224	CDD:275380	9/41 (22%)
		leucine-rich repeat	225..248	CDD:275380	3/22 (14%)
		leucine-rich repeat	249..289	CDD:275380	8/39 (21%)
		leucine-rich repeat	290..311	CDD:275380	6/20 (30%)
		leucine-rich repeat	314..337	CDD:275380	1/22 (5%)
		leucine-rich repeat	353..394	CDD:275380	8/40 (20%)
		leucine-rich repeat	395..418	CDD:275380	5/22 (23%)
		leucine-rich repeat	482..504	CDD:275380	6/40 (15%)
		leucine-rich repeat	505..529	CDD:275380	9/46 (20%)
		leucine-rich repeat	530..553	CDD:275380	7/28 (25%)
		inl_like_NEAT_1	<534..>767	CDD:411101	54/262 (21%)
		leucine-rich repeat	554..583	CDD:275380	7/28 (25%)
		leucine-rich repeat	584..637	CDD:275380	10/67 (15%)
		leucine-rich repeat	607..629	CDD:275380	3/21 (14%)
		leucine-rich repeat	638..662	CDD:275380	8/24 (33%)
		leucine-rich repeat	663..686	CDD:275380	2/22 (9%)
		leucine-rich repeat	687..708	CDD:275380	5/22 (23%)
		leucine-rich repeat	709..732	CDD:275380	4/24 (17%)
		leucine-rich repeat	733..751	CDD:275380	5/19 (26%)
		PCC	738..>821	CDD:188093	21/86 (24%)
		TIR_2	875..1017	CDD:419986	21/71 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920