DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr6

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_017950845.1	Gene:	tlr6 / 100493946	XenbaseID:	XB-GENE-492949	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	815	Identity:	171/815 - (20%)
Similarity:	296/815 - (36%)	Gaps:	197/815 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 ELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQY 485
            |:.::.:..|.| |.|......|:||:.        .|||..|.|.|:......|::.:.|.|..
Frog    21 EIFESHIANYSN-KFLFAVPKNLSSLTT--------VLDISFNSIATMETSEFNYIFDLQVLNAS 76

  Fly   486 GNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSS------KGSFVENFFVQNIDQLY 544
            .|                 |.|.|.....||.|.::|::.|.      .|:|..:  :|::|..:
Frog    77 YN-----------------KMKYLNSSIFKFNTQLQYLDFSHNVLRNISGTFPSH--IQHLDISF 122

  Fly   545 LEANEDEIIDAFGPSDKYFNLKLMEALN-HAIWLFSGEFDEII-LH------HLNSPCPYRCSCC 601
            .......:...||      |:.|:|.|. .|..:...:|:.|: ||      .|||...|.
Frog   123 NNFQTLSVCSGFG------NMVLLEYLGLGADQILKSDFEGIVHLHLKEVFIELNSLNDYE---- 177

  Fly   602 FEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMS-- 664
               :....|:|.:.|:|| :..|.|...|        |.:....||.|::...|.....:|:.
Frog   178 ---NGSLLLLNTKKLTLD-FGVLSNEDRY--------NVLFDAVNTTSVLELSHLQRWNIHIDPK 230

  Fly   665 -------QN-------------------LLRELPLHLLPENITY-------------LDVRNNLL 690
                   ||                   |..:...|...|.:|:             .|..|..:
Frog   231 KYIFNIVQNSKVTDLTMRHVNVEWKMIVLALQYIWHSSVETLTFYDFSLKGLIAKTSFDYSNTSV 295

  Fly   691 KY-----LDDGVIAFLE---YR-------ENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYET 740
            |.     ::.||..|.:   ||       ||:|....|.....|...:..|.|....|..:..:.
Frog   296 KAVNVQGVNVGVFQFDQSSVYRVFSNMNIENLTLNFASLLFMVCPLNSSTFQSIDFSHNALTDDL 360

  Fly   741 V--------LRRVEITDDKCPEDCICCVDTSNSDSLAYV-----------VDCSGKELSEIPQLP 786
            .        |:|:::..:|..:.......|.|..||.|:           .||...:  .|.:|.
Frog   361 FKDCFTLINLKRLKLRKNKLEKIYKLSAMTENMPSLEYLDASHNLLAYDEEDCHWSQ--NIVELN 423

  Fly   787 TPTYGQTT------------LVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPD----- 834
            ..:...|.            |:.|.|.:...||. :.....:....|:.|||.|   |||
Frog   424 LASNFLTASIFKCLPISIKILILESNDITHVPSG-VTHLDDLVELNLSFNRLGD---LPDCSNIS 484

  Fly   835 KLEYLDISNNN--FSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNI-- 895
            .|..|.:..|.  :.:::........|.:::.|       ||:.|.||.:.|:...||....:
Frog   485 SLSLLGVEGNQILYPSIESIESCSRVKHISAGQ-------NPFQCNCELRRFINQEKEAPGTLIG 542

  Fly   896 -ANASAIQCID--TGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFIC-------FRQPI 950
             ..|...:..|  .|..|.:...::|..:|.|....:.:. :||::::.:.:|       |.:
Frog   543 WPEAYVCKYPDHLRGTMLKDFYISEITCNVFILIPVIILP-IIISIALIIGLCKYLDGPWFLK-- 604

  Fly   951 MIWFY---EHEICLSLAARRELDEDKKYDAFLSFTHKDEDLIEE-FVDRLENGRHKFRLCFYLRD 1011
            |||.|   :.....|....:.|..|..::||:|::..|...::. |:..:|......|:|.:.|:
Frog   605 MIWQYTRTKQRTRTSKQGYQSLQRDFDFNAFISYSEHDASWVKNIFLPSIERSNDCIRICQHERN 669

  Fly  1012 WLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHF 1076
            ::.|:||.:.|...::.|.:.|.:::.||::|.|...|...|.|....:....||::|...:..:
Frog   670 FIPGKSIIENIINCIEKSYKSIFILSPNFVQSEWCHYELYFAHHKLYTENNDNLILILLEPIPQY 734

  Fly  1077 --DDLDSELRAYMVLNTYLD-----RNNPNFWNKL 1104
              .....:|:..|...|||:     ..:..||..|
Frog   735 LIPSKYYKLKTLMAQRTYLEWPSEKSKHGLFWANL 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566	12/43 (28%)
		leucine-rich repeat	412..432	CDD:275378	2/10 (20%)
		LRR_4	432..470	CDD:289563	12/37 (32%)
		leucine-rich repeat	433..454	CDD:275378	5/20 (25%)
		leucine-rich repeat	455..478	CDD:275378	7/22 (32%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	5/24 (21%)
		leucine-rich repeat	658..679	CDD:275378	5/48 (10%)
		leucine-rich repeat	680..706	CDD:275378	9/53 (17%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	4/30 (13%)
		leucine-rich repeat	793..815	CDD:275378	6/33 (18%)
		leucine-rich repeat	816..835	CDD:275378	8/23 (35%)
		leucine-rich repeat	836..859	CDD:275378	3/24 (13%)
		TIR	974..1110	CDD:214587	33/139 (24%)
tlr6	XP_017950845.1	leucine-rich repeat	46..69	CDD:275378	7/30 (23%)
		LRR_8	70..125	CDD:404697	15/73 (21%)
		leucine-rich repeat	70..93	CDD:275378	8/39 (21%)
		leucine-rich repeat	94..114	CDD:275378	4/19 (21%)
		leucine-rich repeat	115..139	CDD:275378	5/29 (17%)
		LRR_RI	311..>478	CDD:423007	33/172 (19%)
		leucine-rich repeat	347..369	CDD:275380	2/21 (10%)
		leucine-rich repeat	370..395	CDD:275380	5/24 (21%)
		leucine-rich repeat	396..418	CDD:275380	4/23 (17%)
		leucine-rich repeat	419..440	CDD:275380	3/20 (15%)
		leucine-rich repeat	441..463	CDD:275380	5/22 (23%)
		leucine-rich repeat	464..485	CDD:275380	8/23 (35%)
		leucine-rich repeat	486..509	CDD:275380	3/22 (14%)
		LRRCT	518..570	CDD:214507	13/51 (25%)
		TIR	632..775	CDD:214587	33/138 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070