DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-4 and tlr3

DIOPT Version :9

Sequence 1:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster
Sequence 2:XP_002934448.3 Gene:tlr3 / 100486223 XenbaseID:XB-GENE-491049 Length:897 Species:Xenopus tropicalis


Alignment Length:921 Identity:206/921 - (22%)
Similarity:338/921 - (36%) Gaps:268/921 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   378 CSYNRDKSQLEIDCWQKNLTTIPS-LPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYN 441
            |....|   |..||....|:.||| ||   :...||....|.|.:||..:|..|..|:.||..:|
 Frog    25 CKITED---LTADCSHLKLSAIPSDLP---RNIKALDLSHNQLKKLPAANLSVYDQLERLDAGFN 83

  Fly   442 QLTSLSVSQLPE--SLHYLDIRHNKITTLSPQVVEY--------LYSVNVFNQYGNKWS-----I 491
            .|.....:...:  .|..|::.||:.|.:|.....:        |.|..:.|..||.:.     :
 Frog    84 TLHQFEPALCKQLLMLKTLNLEHNEFTKISENDFTFCVHLSELHLASNGISNIDGNPFEKLENLL 148

  Fly   492 YCDEYH----------------LQEFFWYKAKLLRIKTSKFQ----TIMEYIELSSK-------- 528
            :.|..|                |:|.:....|:.::....|:    |.::.::|||.        
 Frog   149 FLDMSHNKMISTALGNKQQLNNLKELYLNSNKISKLNKEAFEFLANTSLQKLDLSSNPLTEINPG 213

  Fly   529 -----GSF--------------------------VENFFVQNI------------------DQLY 544
                 |||                          |.|..:.||                  ..|.
 Frog   214 CFQAIGSFAALVIQNTQLDPQRTEQVCSELAHTGVRNLTLNNIRLSKIRNTTFKGLADTNLTVLD 278

  Fly   545 LEANEDEIIDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEF 609
            |..|....||    :|.:.:|..:|.||         .:...:.|:|..       .|...:...
 Frog   279 LSGNSLSQID----NDSFVSLGALEILN---------LENNDISHVNPK-------TFNGLSKVR 323

  Fly   610 LINCR-----NLSLD--IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNL 667
            ::|.|     ||.||  .:..|.| :.|   |.::.|:|..:|....:   |..|:..|.:|.:.
 Frog   324 VLNLRKSLSSNLKLDDLSFQSLHN-VQY---LNMEANKIISITEHTFI---GLTSLTNLSLSDST 381

  Fly   668 LRELPLHLLPENITYLDVRNNLLKYL----------DDGVIAFLEYRE------NITKIELSGNP 716
            |::   |.| .|.|:|.:..:.|.:|          ::|....|::.:      |....|:|||.
 Frog   382 LQQ---HTL-TNRTFLSLSKSPLYHLNLTKTGLTKIENGAFLCLKHLQLLDMGLNQIDQEVSGNE 442

  Fly   717 WE--CNCKAKAFLSFLRR---------HEPMEYETVLRRVEIT-DDKCPE-----DCICCVDTSN 764
            .|  .|.: ..:||:.||         ..|...:..||:..:| .|..|.     ..:..:|.||
 Frog   443 LEGLANIE-MIYLSYNRRITLTSNSFIFAPSLSKLYLRKTALTFRDLNPSPFKVLQNLTVLDLSN 506

  Fly   765 SDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKK-W-------PSSLLPGYSSVTRFYL 821
             :::|.:.:...:.||.:          ..|.||.|:|.: |       |...|.|..::.:..|
 Frog   507 -NNIANIQEDVFESLSNL----------RILSFEHNNLARLWKEANPGGPVLFLKGLKNLEKLSL 560

  Fly   822 AHNRLSDIDQLPD-------KLEYLDISNNNF-----SALDDR---------------VRGFLQK 859
            ..|   ..|::|.       ||:.|||..||.     |..||:               |...|.|
 Frog   561 LSN---GFDEIPANAFKGLCKLKVLDIGENNVYILPPSVFDDQHSLTLLDLHKNLITSVEQDLFK 622

  Fly   860 RMNSSQLQLSLFGNPWTCRCED-KDFLVFVKEQAKNIANA-SAIQCIDTGR---SLIEVEETDIC 919
            .:.||...|::.|||:.|.||. ..|..::.....::..| |...|....|   :.::..::..|
 Frog   623 NVFSSLKYLNMGGNPYDCTCESIAWFASWLNTTNTSVPLAHSQYICNTPARYHGNPVDNFDSSPC 687

  Fly   920 PSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICLSLAARRELDEDKK---YDAFLSF 981
            ..:..:...::...|::...::|.:...|...|.||.......:...:|:|..|:   |||::..
 Frog   688 KELAPFRLFVSTFSLMLVFILSVLLIQFQGWRIHFYWTVSINRILGFKEIDPRKRNFDYDAYIIH 752

  Fly   982 THKDEDLIEEFVDRLE-NGRHKFRLCFYLRDWLVGES----IPDCINQSVKGSRRIIILMTKNFL 1041
            ...|...:|..:..|| |...|.:.||..||...|.|    ..||||:    ||:||.::|:|.|
 Frog   753 AQNDVSWVENHLIPLEKNAGSKLQFCFEERDLEAGTSTLSAFVDCINR----SRKIIFVVTRNLL 813

  Fly  1042 KSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEH-FDDLDSELRAYMVLNTYLDRNNPNFWNKLM 1105
            ..:|                |:|.      .|:| |.....:.|..::| .:|: :.|:      
 Frog   814 NDSW----------------CRRF------KVQHAFQQAIEQNRDSIIL-IFLE-DIPD------ 848

  Fly  1106 YSMPHASHLKR 1116
            |.:.|..||:|
 Frog   849 YKLYHTIHLRR 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..386 CDD:275380 2/7 (29%)
leucine-rich repeat 388..408 CDD:275380 8/20 (40%)
LRR_8 412..465 CDD:290566 16/54 (30%)
leucine-rich repeat 412..432 CDD:275378 7/19 (37%)
LRR_4 432..470 CDD:289563 10/39 (26%)
leucine-rich repeat 433..454 CDD:275378 5/22 (23%)
leucine-rich repeat 455..478 CDD:275378 7/30 (23%)
leucine-rich repeat 479..490 CDD:275378 3/10 (30%)
leucine-rich repeat 632..657 CDD:275378 5/24 (21%)
leucine-rich repeat 658..679 CDD:275378 5/20 (25%)
leucine-rich repeat 680..706 CDD:275378 6/41 (15%)
leucine-rich repeat 707..719 CDD:275378 5/13 (38%)
leucine-rich repeat 771..791 CDD:275380 2/19 (11%)
leucine-rich repeat 793..815 CDD:275378 9/29 (31%)
leucine-rich repeat 816..835 CDD:275378 4/25 (16%)
leucine-rich repeat 836..859 CDD:275378 11/42 (26%)
TIR 974..1110 CDD:214587 37/144 (26%)
tlr3XP_002934448.3 PLN00113 26..>507 CDD:215061 111/519 (21%)
leucine-rich repeat 54..74 CDD:275380 7/19 (37%)
leucine-rich repeat 75..98 CDD:275380 5/22 (23%)
leucine-rich repeat 99..122 CDD:275380 6/22 (27%)
leucine-rich repeat 123..146 CDD:275380 5/22 (23%)
leucine-rich repeat 147..170 CDD:275380 2/22 (9%)
leucine-rich repeat 171..196 CDD:275380 4/24 (17%)
leucine-rich repeat 197..230 CDD:275380 6/32 (19%)
leucine-rich repeat 231..273 CDD:275380 4/41 (10%)
leucine-rich repeat 274..297 CDD:275380 7/26 (27%)
leucine-rich repeat 298..319 CDD:275380 6/36 (17%)
leucine-rich repeat 322..347 CDD:275380 7/24 (29%)
leucine-rich repeat 348..371 CDD:275380 6/28 (21%)
leucine-rich repeat 424..448 CDD:275380 6/23 (26%)
PPP1R42 446..637 CDD:411060 47/205 (23%)
leucine-rich repeat 449..472 CDD:275380 4/23 (17%)
leucine-rich repeat 473..498 CDD:275380 5/24 (21%)
leucine-rich repeat 499..522 CDD:275380 5/23 (22%)
leucine-rich repeat 523..554 CDD:275380 9/40 (23%)
leucine-rich repeat 555..578 CDD:275380 4/25 (16%)
leucine-rich repeat 579..602 CDD:275380 9/22 (41%)
leucine-rich repeat 603..623 CDD:275380 2/19 (11%)
PCC 607..>689 CDD:188093 18/81 (22%)
Tlr3_TMD 691..720 CDD:407816 3/28 (11%)
TIR 746..890 CDD:214587 41/148 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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