DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-4 and LOC100485927

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_017946494.1	Gene:	LOC100485927 / 100485927	-ID:	-	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	864	Identity:	202/864 - (23%)
Similarity:	347/864 - (40%)	Gaps:	204/864 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 FTLGINEVA-----CPLK----CNCS----------YNRDKSQLEIDCWQKNLTTIPSLPVPKKG 408
            :.|.|.|::     ||..    |:||          ..||...|.:......:.|...|. |...
Frog    10 YLLAIAELSKGNTDCPCDAAHFCHCSSMHWEAIPSGLPRDVRGLNLSSNAIQIVTETDLK-PYDQ 73

  Fly   409 SSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLP--ESLHYLDIRHNKITTL-SP 470
            ...|:.|.|.:..:.|.|.:...||:.||:|||.|..||.....  ..|.:|::..|:..|| :.
Frog    74 LQTLLLQYNAIHTINDGSFQPLGNLEELDLSYNNLVLLSSVWFRNLNKLKHLNLLGNQYITLGND 138

  Fly   471 QVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENF 535
            .:...|.|::.. |:||:   ..|....|.|    ..|.|:.|.:.....  :.|..:||
Frog   139 SLFASLSSLSSL-QFGNQ---NFDAIQKQSF----EGLERLNTLEINAAQ--LTLYEEGS----- 188

  Fly   536 FVQNIDQLY---LEAN--------ED--------EIIDA-FG-PSD-------KYFNLKLMEALN 572
             :..:.|:|   |..|        :|        ||.|. |. |:|       .|.::|.....|
Frog   189 -LGRMKQIYHTILRVNLTLLPALLKDLVHSVTLLEITDTEFSTPADMQAFEVLAYTSVKQFIFRN 252

  Fly   573 HAIWLFSG-EFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNL--SLDIYPRLPNSIPYKTTL 634
            ..|...|| .|.|||..:.|.             |...:.|||.|  .||. |.|..:....||:
Frog   253 CTIVDVSGYRFVEIIQTYRNI-------------TDVVMKNCRLLGRGLDC-PNLKRTTSSVTTI 303

  Fly   635 YLDRNEIRKLTNTESL--VVAGHASIHKL--HMSQNLLRELPLHLLP-------ENITYLDVRNN 688
            .::..|:       ||  :.:..:|:|::  ..:...:.:.|::|:|       .::.||||...
Frog   304 IINNIEV-------SLYYIFSDLSSLHQIIPQFTYVTVTDSPVYLIPCQFSQSFTSLQYLDVSGG 361

  Fly   689 LL--KYLDDGVIAFLEYRE-----------NITKIELSGNPWECNCKAKAFLSFLRRHEPMEYET 740
            .|  .||...|.    |.|           |:::..|:..|     |...|||.|         .
Frog   362 KLDNTYLGSSVC----YHEGGGACPKLQTLNVSRNLLTSVP-----KVAQFLSGL---------N 408

  Fly   741 VLRRVEITDDKCPEDCICCVDTSNSD---SLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSL 802
            .|..::|:.:|..|     :.||...   :|.| ::.|..:::.|.....||.  ..|....|.|
Frog   409 YLTNLDISQNKFSE-----LSTSKCQWPKNLKY-LNISNNQINIITTCIPPTL--QILDVSSNYL 465

  Fly   803 KKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPD-----KLEYLDISNNNFSALDDRVRGFLQKRMN 862
            ..:...:    .::|..|:::||||   :||:     .|..|.||.|:       :.||.|..:.
Frog   466 TVFAIEM----PNLTELYISNNRLS---KLPEGMYFTSLVLLSISRND-------LNGFGQSDLE 516

  Fly   863 --SSQLQLSLFGNPWTCRCEDKDFLVFVKEQA-------KNIANASAIQCIDTGRSLIEVEETDI 918
              |::..|....|.:.|.|:   ||.|::...       .|...||.....|     :::::.::
Frog   517 LFSNRTILDARANNYKCSCQ---FLDFIRSNTAVLVGWPDNYKCASPASVKD-----VQIQDANL 573

  Fly   919 CPSVLIYYTSLAVSL---LIIALSINVFICFRQPIMIWFYEHEICLSLAARREL---DEDKKYDA 977
            .|  |:.:.:|.|:|   |:|||...:........::|:.:.......|.|:.|   |.:..:|.
Frog   574 PP--LVCHKTLIVTLSCILLIALVAAIVALCHFLHVVWYAKMTWAWLKAKRKPLKNCDREICFDG 636

  Fly   978 FLSFTHKDEDLIEE-FVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFL 1041
            |:|::.:|.:.:|. .|.:|||.....:||.:.||::.|:.|.|.|..:::.|.:.:.:::::|:
Frog   637 FVSYSERDSEWVENMMVPKLENATLAMKLCLHKRDFVPGKWIIDNIIDAMEKSYKTVFVLSEHFV 701

  Fly  1042 KSTWGRLE-----FRLALHATSRDRCKRLIVVLYP-DVEHFDDLDSELRAYMVLNTYL-----DR 1095
            :|.|.:.|     |||    ...:....::::|.| :.|.......:||..|...|||     :.
Frog   702 RSEWCKYELEFSHFRL----FDENNDSAILILLDPIEKETVPKRFCKLRKLMNTKTYLEWPTDEE 762

  Fly  1096 NNPNFWNKLMYSMPHASHL 1114
            ....||:.|..::..|.::
Frog   763 QQEVFWDNLKTALQPADYI 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	10/41 (24%)
		leucine-rich repeat	388..408	CDD:275380	3/19 (16%)
		LRR_8	412..465	CDD:290566	18/54 (33%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	15/40 (38%)
		leucine-rich repeat	433..454	CDD:275378	9/22 (41%)
		leucine-rich repeat	455..478	CDD:275378	6/23 (26%)
		leucine-rich repeat	479..490	CDD:275378	3/10 (30%)
		leucine-rich repeat	632..657	CDD:275378	5/26 (19%)
		leucine-rich repeat	658..679	CDD:275378	4/29 (14%)
		leucine-rich repeat	680..706	CDD:275378	10/38 (26%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	4/19 (21%)
		leucine-rich repeat	793..815	CDD:275378	3/21 (14%)
		leucine-rich repeat	816..835	CDD:275378	8/23 (35%)
		leucine-rich repeat	836..859	CDD:275378	7/22 (32%)
		TIR	974..1110	CDD:214587	37/147 (25%)
LOC100485927	XP_017946494.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010