DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_002933537.2	Gene:	tlr2 / 100485771	XenbaseID:	XB-GENE-481145	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	850	Identity:	177/850 - (20%)
Similarity:	324/850 - (38%)	Gaps:	220/850 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 CPLK----CNCSYNRDKSQLEIDCWQKNLTTIPS-LPVPKKGSSALVFQSNLLAELPDNSLEGYH 431
            ||..    |:||...         |:    .||| ||...:|   |...||.:..:.:..|:.|.
Frog    26 CPCDAANFCHCSSMH---------WE----AIPSGLPRDVRG---LNLSSNAIQIVTETDLQPYD 74

  Fly   432 NLKSLDVSYNQLTSLSVSQLPE--SLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKW----- 489
            .|::|.:.||.:.:::......  :|..||:.:|.::.||......||::...|..||::
Frog    75 QLQTLLLQYNAIHTINDGSFQPLGNLEELDLSYNNLSHLSSAWFRNLYNLKHLNLLGNQYLTLGN 139

  Fly   490 -SIYCDEYHLQEFFWYKAKLLRIKTSKFQT-----IMEYIELSSKGSFVENFF--VQNIDQLYLE 546
             |::.....|:...:.......|:...|::     |:| |:.:..|.:.|...  ::.|:...|.
Frog   140 NSLFASLSSLRSLQFGNQDFSAIQKLHFESLERLNILE-IKAAQLGLYEEGSLAAIKQINHAVLT 203

  Fly   547 ANEDEIIDAFGPSDKYFNLK-LMEALNHAIWL-------FSGEFDEIILHHLNSPCPYRCSCCFE 603
            .|..             ||: |:....|::.|       |....|...:..||..
Frog   204 VNIQ-------------NLRALLNDFIHSVTLLEMKDMQFGDAADVKAMVILNDT---------- 245

  Fly   604 WHTGEFLI--NC--------RNLSL-DIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGH-- 655
              :.::|:  ||        |.|.: ..|..:.:.|...:|||        .|.|.|.|:...
Frog   246 --SIKYLVFRNCIITDQSASRLLEIFQTYRNITDFILDDSTLY--------GTGTASPVIGDDPF 300

  Fly   656 ----ASIHKLHMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNP 716
                |.|:|||             :|:...:.|::         |:.......:||..|:
Frog   301 SVTTAIINKLH-------------IPKFFLFSDLQ---------GIYKLASNFKNIACID----- 338

  Fly   717 WECNCKAKAFL---SFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKE 778
                  :|.||   :|.|....::|..:  ...:..|.......|..:...:..:...::.|...
Frog   339 ------SKVFLMPCAFSRSFSSLQYLDL--SGNLLSDNLLASSACAFEGGGAWPILQTLNVSRNL 395

  Fly   779 LSEIPQLPTPTYG---QTTLVFERN-------SLKKWPSSLLPGYSSVTRFYL--AHNRLSDIDQ 831
            |:.:.:|...|.|   .|.|...:|       |..:||.||.         ||  :.:::|:|..
Frog   396 LTSLRRLAQITSGLKYLTNLDVSQNNFGELSTSTCQWPKSLK---------YLNISSSQMSNITC 451

  Fly   832 LPDKLEYLD--------------------ISNNNFSALDDRV---RGFL----QKRMNS-SQLQL 868
            :|..|:.||                    ||||..|.|.:.:   |.|:    :.::|. .|..|
Frog   452 IPPTLQILDVSSNYLTVFTIKMPNLTELYISNNRLSKLPEGMYFPRLFMLSIDRNKLNDFYQSDL 516

  Fly   869 SLF---------GNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSL--IEVEETDICPSV 922
            .||         .|.:.|.|:   ||.|:......:.........|:..|:  ..:::.::.|
Frog   517 DLFPQLTTLDGRDNNYLCSCQ---FLSFMHSHTIALVGWPDDYICDSPSSVRGKRIQDANLPP-- 576

  Fly   923 LIYYTSLAVSL---LIIALSINVFICFRQPIMIWFYEHEICLSLAARREL---DEDKKYDAFLSF 981
            |:.:.:|.|:|   |:|||...:........::|:.:.......|.|:.|   |.:..|:.|:|:
Frog   577 LVCHKTLIVTLSCILLIALVAAIAALCHFLHVVWYAKMTWAWLKAKRKPLKNCDREICYNGFVSY 641

  Fly   982 THKDEDLIEE-FVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTW 1045
            :.:|.:.:|. .|.:|||.....:||.:.||::.|:.|.|.|..:::.|.:.:.:::::|::|.|
Frog   642 SERDSEWVENMMVPKLENAVPPMKLCLHKRDFVPGKWIIDNIIDAMEKSYKTVFVLSEHFVRSEW 706

  Fly  1046 GRLEFRLALHATSRDRCKRLIVVLYPDVEH------FDDLDSELRAYMVLNTYL-----DRNNPN 1099
            .:.|...:......:.....|::|...:|:      |    .:||..|...|||     :.....
Frog   707 CKYELEFSHFRLFDENNDTAILILLEPIENETVPKRF----CKLRKLMNTKTYLEWPTDEEQQEV 767

  Fly  1100 FWNKL 1104
            ||:.|
Frog   768 FWDNL 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	5/17 (29%)
		leucine-rich repeat	388..408	CDD:275380	6/20 (30%)
		LRR_8	412..465	CDD:290566	13/54 (24%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	9/39 (23%)
		leucine-rich repeat	433..454	CDD:275378	4/22 (18%)
		leucine-rich repeat	455..478	CDD:275378	7/22 (32%)
		leucine-rich repeat	479..490	CDD:275378	3/16 (19%)
		leucine-rich repeat	632..657	CDD:275378	7/30 (23%)
		leucine-rich repeat	658..679	CDD:275378	5/20 (25%)
		leucine-rich repeat	680..706	CDD:275378	2/25 (8%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	4/19 (21%)
		leucine-rich repeat	793..815	CDD:275378	8/28 (29%)
		leucine-rich repeat	816..835	CDD:275378	5/20 (25%)
		leucine-rich repeat	836..859	CDD:275378	11/49 (22%)
		TIR	974..1110	CDD:214587	34/142 (24%)
tlr2	XP_002933537.2	internalin_A	55..>247	CDD:380193	41/217 (19%)
		leucine-rich repeat	55..75	CDD:275378	5/19 (26%)
		LRR_8	75..133	CDD:404697	14/57 (25%)
		leucine-rich repeat	76..99	CDD:275378	4/22 (18%)
		leucine-rich repeat	100..123	CDD:275378	7/22 (32%)
		leucine-rich repeat	124..148	CDD:275378	4/23 (17%)
		leucine-rich repeat	149..162	CDD:275378	1/12 (8%)
		leucine-rich repeat	322..352	CDD:275378	9/49 (18%)
		PRK15370	<353..>508	CDD:185268	32/165 (19%)
		leucine-rich repeat	355..382	CDD:275380	3/28 (11%)
		leucine-rich repeat	386..411	CDD:275380	5/24 (21%)
		leucine-rich repeat	412..435	CDD:275380	6/22 (27%)
		leucine-rich repeat	436..455	CDD:275380	6/27 (22%)
		leucine-rich repeat	456..475	CDD:275380	3/18 (17%)
		leucine-rich repeat	476..497	CDD:275380	6/20 (30%)
		leucine-rich repeat	498..521	CDD:275380	6/22 (27%)
		TIR	634..779	CDD:214587	34/142 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070