DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-4 and tlr14.2

DIOPT Version :9

Sequence 1:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster
Sequence 2:	XP_012810129.1	Gene:	tlr14.2 / 100485512	XenbaseID:	XB-GENE-5824915	Length:	844	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	197/903 - (21%)
Similarity:	345/903 - (38%)	Gaps:	262/903 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 KSHCKFTLGINEV---ACPLKCNCSYNRDKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNL 418
            |.|..|.| :|.:   :|...|    .||.:....:|..::|..:| .|||..:   :|....|.
Frog    30 KVHVCFLL-LNLLKWTSCQNPC----QRDSTNRYANCQGQDLVEVPQDLPVTLQ---SLDLSYNR 86

  Fly   419 LAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQLPES--LHYLDIRHNKITTLSPQVVEYLYSVNV 481
            |..:.......|.||::|::|:|.::::.......:  |..|.:.:|.:|.:...:.|.|
Frog    87 LFHIRYEDFSSYTNLRALNLSFNNISTIECGSFASNTLLRNLTLFNNSLTEMPSTLFEPL----- 146

  Fly   482 FNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSK-------GSFVENFF-VQ 538
                                                .::|::::|:.       |...||.. :|
Frog   147 ------------------------------------LLLEFLDVSNNLYNYSTLGKVFENLVNLQ 175

  Fly   539 NI---DQLYLEANEDEIIDAFGPSDKYFNLKLM-----------EALN-HAIWL-----FSGEFD 583
            |:   ..|..:..:|:.......|.|.|:||.|           |.|| ..:||     .:.:..
Frog   176 NLAIGGPLVSKVLKDDFAPIKNRSLKKFSLKTMSKLGFYEPGALEVLNTRVLWLDISLDTNAQAL 240

  Fly   584 EIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYL-----DRNEIRK 643
            .:||..|               .|:.:.:.|      :.||..|..|..|:.|     |.| ||:
Frog   241 PLILKDL---------------AGKTIDSLR------FRRLFESSYYTDTMDLFCGLVDIN-IRE 283

  Fly   644 L-----TNTESLVVAGHASIHKLHMS--QNLL-------REL---PLHLLPENITYLD------- 684
            |     ..||:|:   |.::|.:..|  |:||       |.|   ..|:|.:.: ||:
Frog   284 LIFFRGMFTENLL---HQALHSIQKSTIQDLLLLSVKFDRSLNTNNTHILFDRL-YLNSLVIRDI 344

  Fly   685 -----------------VRNNLLKYLDDGVIAFLEYRE--NITKIELSGNP-----------WEC 719
                             |||..|..:..|.:..:.:|:  ||..:::|.|.           |:.
Frog   345 AGPHIFKYDWTFTWFSKVRNLQLSRVHLGSLPCIAWRQMGNIECLDVSDNRLIGSNLYNPSCWDG 409

  Fly   720 NC-KAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIP 783
            .. |...|::.....:.      ||.:.:...|.|:  :..:|.|::|...|...|:.     ||
Frog   410 GLPKLDTFIAANNNLQS------LRLISLLTAKWPK--LTKLDLSSNDLGVYNEVCTW-----IP 461

  Fly   784 QLPTPTYGQTTLVFERNSLKKWPSSLLP--------GYS--------------SVTRFYLAHNRL 826
            .:       |||:.:.|:||......||        .||              ::....|:||:|
Frog   462 NI-------TTLILKGNTLKMCVFQCLPTSVELLDLSYSQLEQLDLNYFNRATNLKELVLSHNKL 519

  Fly   827 SDI--DQLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVK 889
            :.|  |.....|:.|.:..|:.|.:|   :|..:..  .|..:|:...||:.|.|   |...|..
Frog   520 NFISSDWRSPNLQVLHLEGNSISLID---KGTFKDL--PSLRRLTAGNNPYDCTC---DLYAFFS 576

  Fly   890 EQAKNIANASA-----IQCIDTGRSLIEVEETDI---------CPSVLIYYTSLAVSLLIIALSI 940
            ....|.....|     .||....    .:.:||:         |...|:...|::.:..||.|.
Frog   577 TLQNNDEMLLADWPYDYQCFHPQ----HLRDTDVEDYTPWRVECDVSLVITISVSTTAAIIILC- 636

  Fly   941 NVFICFRQPI-----MIWFYEHEICLSLAARRELDEDKKYD--AFLSFTHKDEDLIE-EFVDRLE 997
             :.:|:|..:     |.|    .|..|....::.::.::|:  ||:|:::.|.|.:. |.:.|||
Frog   637 -MLVCWRFDVPWYLRMTW----RIVKSKYRSKKSNKSREYNYHAFISYSYSDADWVRGELLYRLE 696

  Fly   998 NGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRC 1062
            :....:|:|.:.||:|.|..|.|.|.::::.||:||.:::.||:.|.|...|...| |..:....
Frog   697 SCSPPYRVCIHERDFLPGRWIIDNIIENIENSRKIIFVLSSNFINSEWCNYELYFA-HQRAIGHS 760

  Fly  1063 KRLIVVLYPDVEHFDDLDS---ELRAYMVLNTYLD-RNNPN----FWNKLMYSMPHAS 1112
            ...|:::..:....:||..   :||..:...|||: .:.|:    ||.:|...:..||
Frog   761 LEDIILVVKEKVTMEDLPKRFHKLRKMLRTKTYLEWPSEPSKQHFFWIQLKSILGDAS 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	9/30 (30%)
		leucine-rich repeat	388..408	CDD:275380	6/20 (30%)
		LRR_8	412..465	CDD:290566	12/54 (22%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	9/39 (23%)
		leucine-rich repeat	433..454	CDD:275378	4/20 (20%)
		leucine-rich repeat	455..478	CDD:275378	6/22 (27%)
		leucine-rich repeat	479..490	CDD:275378	0/10 (0%)
		leucine-rich repeat	632..657	CDD:275378	11/34 (32%)
		leucine-rich repeat	658..679	CDD:275378	9/32 (28%)
		leucine-rich repeat	680..706	CDD:275378	8/51 (16%)
		leucine-rich repeat	707..719	CDD:275378	4/22 (18%)
		leucine-rich repeat	771..791	CDD:275380	3/19 (16%)
		leucine-rich repeat	793..815	CDD:275378	10/43 (23%)
		leucine-rich repeat	816..835	CDD:275378	6/20 (30%)
		leucine-rich repeat	836..859	CDD:275378	6/22 (27%)
		TIR	974..1110	CDD:214587	42/146 (29%)
tlr14.2	XP_012810129.1	LRR_8	76..135	CDD:338972	12/61 (20%)
		leucine-rich repeat	77..100	CDD:275378	4/25 (16%)
		leucine-rich repeat	101..124	CDD:275378	4/22 (18%)
		leucine-rich repeat	125..148	CDD:275378	6/63 (10%)
		leucine-rich repeat	149..173	CDD:275378	5/23 (22%)
		leucine-rich repeat	219..280	CDD:275380	17/81 (21%)
		leucine-rich repeat	281..321	CDD:275380	12/42 (29%)
		LRR	299..>558	CDD:227223	58/284 (20%)
		leucine-rich repeat	365..385	CDD:275380	3/19 (16%)
		leucine-rich repeat	386..413	CDD:275380	4/26 (15%)
		leucine-rich repeat	414..435	CDD:275380	3/26 (12%)
		leucine-rich repeat	440..484	CDD:275380	15/55 (27%)
		leucine-rich repeat	485..508	CDD:275380	2/22 (9%)
		LRR_8	508..564	CDD:338972	14/60 (23%)
		leucine-rich repeat	509..530	CDD:275380	6/20 (30%)
		leucine-rich repeat	531..554	CDD:275380	6/27 (22%)
		TPKR_C2	563..>603	CDD:387596	10/46 (22%)
		TIR	673..810	CDD:214587	40/137 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060