DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-zeta and IGSF9

DIOPT Version :9

Sequence 1:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	339	Identity:	80/339 - (23%)
Similarity:	147/339 - (43%)	Gaps:	59/339 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LNIVVEE-------PEFTEYIENVTVPAGRNVKLGCSVKNLGS----YKVAWMHFEQSAILTVHN 159
            |::|:.:       ||    :.:|...||.:|.|||.:.....    :.:.|:.|  ..:|.:..
Human    10 LSLVISQGADGRGKPE----VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF--GFLLPIFI 68

  Fly   160 HVITRNPRISVTHDKHDR-HRTWYLHINNVHEEDRGRYMCQINTVT--------AKTQFGYLNVV 215
            .....:|||...:....| .:...|.|..:..||:|.|.|::..:.        |...:.:|.|.
Human    69 QFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVN 133

  Fly   216 VPPNIDDSLSSSDVIVREGANISLRCRASGSPRPIIKWK---RDDNSRIAINKNHIVNEWEGDTL 277
            .||...:: ..:.:.|:|...::|||.|.|||.|.:.||   :|      :.:.....:.:..||
Human   134 SPPQFQET-PPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKD------LGQGQGQVQVQNGTL 191

  Fly   278 EITRISRLDMGAYLCIASNGVPPTVSKRIKVSVDFPPMLLIP--HQLVGAPEGFNVTIECFTEAH 340
            .|.|:.|...|.|.|.||: ...:.:...::.|..||::::|  :..|.|.:  :|::.|..||:
Human   192 RIRRVERGSSGVYTCQASS-TEGSATHATQLLVLGPPVIVVPPKNSTVNASQ--DVSLACHAEAY 253

  Fly   341 PTSLNY-WTRGEGPIIHDSHKYKVEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGETDG 404
            |.:|.| |.:....:.|.|   :::..|.:   .....|.::.....|.|.|.||..|      |
Human   254 PANLTYSWFQDNINVFHIS---RLQPRVRI---LVDGSLRLLATQPDDAGCYTCVPSN------G 306

  Fly   405 IIRLYVSYPPTTAS 418
            ::     :||:.::
Human   307 LL-----HPPSASA 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	24/108 (22%)
		Ig	130..200	CDD:143165	18/74 (24%)
		I-set	226..310	CDD:254352	23/86 (27%)
		IGc2	233..298	CDD:197706	22/67 (33%)
		Ig	313..410	CDD:299845	24/99 (24%)
		IG_like	325..410	CDD:214653	20/85 (24%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	25/113 (22%)
		IG_like	28..110	CDD:214653	21/83 (25%)
		I-set	136..223	CDD:254352	24/94 (26%)
		Ig	154..220	CDD:143165	21/72 (29%)
		Ig_3	226..305	CDD:290638	22/86 (26%)
		IG_like	233..319	CDD:214653	23/102 (23%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810